Widespread hepatitis C virus transmission network among people who inject drugs in Kenya
Rattachement africain : us, Kenya, gb. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
OBJECTIVES: Hepatitis C virus (HCV) disproportionately affects people who inject drugs (PWID) worldwide. Despite carrying a high HCV burden, little is known about transmission dynamics in low- and middle-income countries. METHODS: We recruited PWID from Nairobi and coastal cities and towns of Mombasa, Kilifi, and Malindi in Kenya at needle and syringe programs. Next-generation sequencing data from HCV hypervariable region 1 were analyzed using Global Hepatitis Outbreak and Surveillance Technology to identify transmission clusters. RESULTS: HCV strains belonged to genotype 1a (n = 64, 46.0%), 4a (n = 72, 51.8%) and mixed HCV/1a/4a (n = 3, 2.2%). HCV/1a was dominant (61.2%) in Nairobi, whereas HCV/4a was dominant in Malindi (85.7%) and Kilifi (60.9%), and both genotypes were evenly identified in Mombasa (45.3% for HCV/1a and 50.9% for HCV/4a). Global Hepatitis Outbreak and Surveillance Technology identified 11 transmission clusters involving 90 cases. Strains in the two largest clusters (n = 38 predominantly HCV/4a and n = 32 HCV/1a) were sampled from all four sites. CONCLUSIONS: Transmission clusters involving 64.7% of cases indicate an effective sampling of major HCV strains circulating among PWID. Large clusters involving 77.8% of clustered strains from Nairobi and Coast suggest successful introduction of two ancestral HCV/1a and HCV/4a strains to PWID and the existence of a widespread transmission network in the country. The disruption of this network is essential for HCV elimination.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Widespread hepatitis C virus transmission network among people who inject drugs in Kenya
- Date Crossref
- 01/10/2024
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
-
Albert Einstein College of Medicine Department of Medicine pays non établi dans la noticeUniversité ou école supérieure
-
Centers for Disease Control and Prevention pays non établi dans la noticeOrganisme public
-
Ministry of Health Nairobi, Kenya (code pays fourni par la source)Organisme public
-
University of Bristol pays non établi dans la noticeUniversité ou école supérieure
-
Division of Viral Hepatitis pays non établi dans la noticeInstitution
-
Yale University School of Nursing pays non établi dans la noticeUniversité ou école supérieure
Department of Medicine — Albert Einstein College of Medicine, Centers for Disease Control and Prevention et Ministry of Health (Nairobi, Kenya), avec 3 autres affiliations. Pays d’affiliation : Kenya.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.