Yvan Martineau

Src promotes tumor cell invasion by hijacking the translation machineries

Benjamin Bonnard, Anouk Chatefau, Cyril Dourthe, Sylvaine Di Tommaso et autres

Strategies combined with RAS targeting in pancreatic adenocarcinoma: scientific hope and therapeutic horizons

Lea Fevrier, Brice Chanez, Nelson Dusetti, Louis de Mestier et autres

Le syndrome de Lynch est la principale prédisposition héréditaire aux cancers colorectaux et extra-coliques, lié à des variants pathogènes constitutionnels des gènes MMR (MLH1, MSH2, MSH6, PMS2 ou EPCAM) responsables d’une déficience de réparation des mésappariements et d’instabilité microsatellites (dMMR/MSI-H). Il confère …

Molecular subtypes in pancreatic cancer: from academic promise to clinical reality

Daniela Mercedes D’Empaire Altimari, Michele Bevere, Elisa Espinet, Yvan Martineau et autres

Pancreatic ductal adenocarcinoma (PDAC) continues to rank among the most lethal malignancies, with five-year survival rates stubbornly below 12%. Over the past decade and a half, transcriptomic analyses have consistently identified molecular subtypes - particularly the classical/progenitor (GATA6-high) and basal-like/squamous (GATA6-low) - …

es, it, fr, nl (code pays fourni par la source)

Drosophila melanogaster miPEP8 Regulates Cell Size Through its Interaction With ref(2)P/p62

Carine Duboé, Clémence Guillon, Nathanael Jariais, Jessica Boutet et autres

MiPEPs are microproteins encoded by primary transcripts of microRNAs (pri-miRNAs). Initially identified in plants, we recently characterized a miPEP in Drosophila melanogaster, named miPEP8, which is involved in the regulation of wing size. However, mechanisms at play are unknown. In the present …

fr, us (code pays fourni par la source)

Src promotes tumor cell invasion by hijacking the translation machineries

Benjamin Bonnard, Anouk Chatefau, Cyril Dourthe, Sylvaine Di-Tommaso et autres

The Src oncogene controls cancer cell invasiveness by promoting invadosome formation and extracellular matrix (ECM) degradation. Invadosomes are translational hotspots enriched in the eukaryotic translation initiation factor 3 (eIF3) complex that is mandatory for their maintenance. Here, we determined that Src regulates …

fr (code pays fourni par la source)

Decoding the Integrated Stress Response of Pancreatic Cancer: Identifying a Serine‐dependent Tumor Subset Under Metabolic Relationships With CAFs.

Sauyeun Shin, Mehdi Liauzun, Jacobo Solórzano, Morgane Le Bras et autres

Pancreatic ductal adenocarcinoma (PDA) transcriptomic profiling has identified prognostic subtypes, yet patient-specific first-line therapies remain elusive. Here, we stratified PDA tumors by mRNA translation rates, a frequently dysregulated step in gene expression, using translatome profiling of 27 patient-derived xenografts (PDXs). Unsupervised analysis …

fr, se (code pays fourni par la source)

Mechanisms for stroma-induced secondary chemoresistance in pancreatic adenocarcinoma

Corinne Bousquet, Ludmila Recoules, Hippolyte Audureau, Jérôme Raffenne et autres

Drosophila melanogaster miPEP8 regulates cell size through its interaction with ref(2)P/p62

Carine Duboé, Clémence Guillon, Jessica Boutet, Nathanael Jariais et autres

Abstract MiPEPs are microproteins encoded by primary transcripts of microRNAs (pri-miRNAs). Initially identified in plants, we recently characterized a miPEP in Drosophila melanogaster , named miPEP8, which is involved in the regulation of wing size. However, mechanisms at play are unknown. In …

fr, gb, us (code pays fourni par la source)

Unveiling FKBP7 as an early endoplasmic reticulum sentinel in pancreatic stellate cell activation, collagen remodeling and tumor progression

Christophe Quémerais, Christine Jean, Alexia Brunel, Emilie Decaup et autres

In pancreatic ductal adenocarcinoma (PDAC), fibroblast activation leads to excessive secretion of extracellular matrix (ECM) and soluble factors that regulate tumor progression, prompting investigation into endoplasmic reticulum (ER)-resident proteins that may support this activation. We identified FKBP7, a peptidyl-prolyl isomerase in the …

fr (code pays fourni par la source)

Unveiling Fkbp7 as an Early Endoplasmic Reticulum Sentinel in Pancreatic Stellate Cell Activation, Collagen Remodelling and Tumor Progression

Christophe Quémerais, Christine Jean, Alexia Brunel, Emilie Decaup et autres

fr (code pays fourni par la source)

Mass Spectrometry-Based Workflow for the Identification and Quantification of Alternative and Canonical Proteins in Pancreatic Cancer Cells

Clémence Guillon, Carole Pichereaux, Ikrame Lazar, Karima Chaoui et autres

The identification of small proteins and proteins produced from unannotated open reading frames (called alternative proteins or AltProts) has changed our vision of the proteome and has attracted more and more attention from the scientific community. Despite several studies investigating particular AltProts …

fr (code pays fourni par la source)

Tumoral mechanical stress reprograms adjacent tissue micro-environment to fuel pancreatic tumor progression: identification of a new subtype of activated fibroblasts.

Claire Lac, Pauline Thomas, Julie Foncy, Marjorie Fanjul et autres

International audience

fr (code pays fourni par la source)