İsmail Koyuncu

Melatonin Protects BEAS‐2B Cells Against Hypoxia/Reoxygenation‐Induced Injury By Reducing MLKL Levels, Suppressing Oxidative Stress and Preserving Mitochondrial Function

Zehra Yılmaz, Askin Tas, Özlem Öz, İsmail Koyuncu et autres

Necroptosis has been demonstrated to play a role in the process of lung ischemia-reperfusion injury (LIRI) in a variety of clinical conditions, including cardiopulmonary bypass and pulmonary embolism. Melatonin has been reported to exert a protective role by reducing oxidative stress and …

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Therapeutic Hypothermia Modulates S100B and Oxidative Stress in Neonatal Hypoxic–Ischemic Encephalopathy: Implications of SDF4 as a Novel Biomarker

Fatih İşleyen, Celil Yılmaz, İsmail Koyuncu

AIM: This study investigated the dynamic profile of stromal cell-derived factor 4 (SDF4), a hypoxia-inducible chemokine and S100B, an established astroglial injury marker, in neonates with hypoxic-ischemic encephalopathy (HIE) undergoing therapeutic hypothermia (TH). Its potential as a biomarker was assessed by examining …

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Metabolomic Analysis of Intracellular Amino Acid Profile Differences Between Cisplatin-Resistant and Cisplatin- Sensitive CALU-1 Lung Cancer Cells

İsmail Koyuncu, Mehmet Ali Tapsık, Özgür Yüksekdağ, Murat Tiken et autres

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Selective Anticancer Effects of Haplophyllum Ptilostylum Extract on SNU-423 Liver Cancer Cells via Mitochondrial Dysfunction and Apoptosis Anticancer effects of H. ptilostylum on SNU-423

Mustafa Orhan Tunçel, İsmail Koyuncu, Ebru Temiz, Kadir Eği et autres

Hepatocellular carcinoma is one of the most common and lethal cancers worldwide, creating an urgent need for new therapeutic agents. In this context, the present study aimed to investigate the selective anticancer effects of Haplophyllum ptilostylum on SNU-423 liver cancer cells, with …

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Assessment of NLRP3, Caspase-1, and IL-18 Levels in Pediatric Sepsis

Sadullah Toprak, Murat Arı, Hatice Feray Arı, İsmail Koyuncu

Backround: Pediatric sepsis remains a leading cause of critical illness and mortality among children admitted to pediatric intensive care units (PICU). Early and accurate diagnosis is essential for timely intervention and improved clinical outcomes. Recent evidence suggests that inflammasome-related biomarkers, including NOD-like …

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Pediatrik Sepsiste NLRP3, Kaspaz-1 ve IL-18 Düzeylerinin Değerlendirilmesi

Sadullah Toprak, Murat Arı, Hatice Feray Arı, İsmail Koyuncu

Backround: Pediatric sepsis remains a leading cause of critical illness and mortality among children admitted to pediatric intensive care units (PICU). Early and accurate diagnosis is essential for timely intervention and improved clinical outcomes. Recent evidence suggests that inflammasome-related biomarkers, including NOD-like …

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Retraction notice to “Defected Ag/Cu-MOF as a modifier of polyethersulfone membranes for enhancing permeability, antifouling properties and heavy metal and dye pollutant removal” [Sep. Purif. Technol. 345 (2024) 127336]

Vahid Vatanpour, Rabia Ardic, Berk Esenli, Bahriye Eryildiz-Yesir et autres

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Membrane Fouling in Vibratory MBRs: Impact Distance Complements Wall Shear Stress as a Fouling Predictor

Recep Kaya, Mustafa Evren Ersahin, Hale Ozgun, Volodymyr V. Tarabara et autres

Computational fluid dynamics (CFD) modeling and lab-scale preliminary tests were performed to elucidate mechanisms of membrane fouling control in vibratory hollow fiber membrane bioreactors. Shear stress distribution on the hollow fiber membrane surfaces was estimated analytically and compared with predictions by 3D …

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Protective Effects of Riociguat Against Contrast‐Induced Nephropathy: An Experimental and Machine Learning‐Based Study in Rats

Mustafa Beğenç Taşcanov, Kenan Toprak, Sibel Türedi, İsmail Koyuncu et autres

Contrast-induced nephropathy (CIN) is an important cause of acute kidney injury following exposure to iodinated contrast media, and effective preventive strategies remain limited. This study investigated the renoprotective effects of riociguat, a soluble guanylate cyclase stimulator, in an experimental rat model of …

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Targeted Metabolomic Profiling of Carnitines Reveals Diagnostic Candidates in Postpartum Cardiomyopathy

Yasemin Behram Kandemir, İsmail Koyuncu, Veysel Tosun, Ünal Güntekin

Background: Postpartum cardiomyopathy (PPCM) is a rare but life-threatening condition characterized by left ventricular dysfunction occurring in the peripartum period. Alterations in carnitine metabolism have been implicated in myocardial energy dysregulation, yet targeted metabolic profiling in PPCM remains limited. Methods: We conducted …

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CA IX Inhibition by a Sulfonamide Compound: A Therapeutic Approach Against Breast Cancer

Şükrü Akmeşe, Ebru Temiz, Elif Gürel, İsmail Koyuncu et autres

Carbonic anhydrase IX (CA IX) is overexpressed in many solid tumors, contributing to cancer cell proliferation, survival, invasion, and metastasis. Sulfonamide-based compounds have emerged as potential anticancer agents by inhibiting this enzyme. In this study, we investigated the anticancer potential of a …

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Nuclear factor erythroid 2 related factor 2, tumor necrosis factor alpha, interleukin-40, and endorepellin levels in patients undergoing coronary artery bypass grafting

Reşat Dikme, İsmail Koyuncu, Mehmet Salih Aydın

OBJECTIVE: The aim of this study was to evaluate the levels of nuclear factor erythroid 2 related factor 2, tumor necrosis factor alpha, interleukin-40, and endorepellin in patients undergoing coronary artery bypass grafting and explore their potential diagnostic roles. METHODS: The study …

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