Gyochang Keum

Cardiac immunomodulatory therapy via T cell-targeted RNA interference for treatment of myocardial infarction

Ju‐Ro Lee, Sung Pil Kwon, Woo‐Sup Sim, Bong‐Woo Park et autres

Modulation of adaptive immunity represents a promising therapeutic strategy for reconstructing a favorable immune microenvironment and preventing adverse remodeling after myocardial infarction (MI). Here, we established a nanotherapeutic platform for systemic modulation of T cell immunity to promote cardiac repair after MI. …

us, kr (code pays fourni par la source)

Nonclinical safety evaluation strategies for mRNA/LNPs platform agents: Evidence from comprehensive animal toxicity studies

Jae-Hun Ahn, Na-Young Lee, Hee-Jin Bae, Jooil Kim et autres

kr (code pays fourni par la source)

Lipid Nanoparticle Database towards structure-function modeling and data-driven design for nucleic acid delivery

Evan Collins, Jungyong Ji, Sung-Gwang Kim, Jacob J. Witten et autres

Lipid nanoparticles (LNPs) are the leading nonviral nucleic acid delivery technology, but LNP structure-function data remains fragmented and nonstandardized. Unlike protein engineering which is anchored by the centralized Protein Data Bank, the LNP field lacks a unified repository for systematic analysis. To …

us, kr (code pays fourni par la source)

Enhanced subchronic cardiac stress of high doses of a novel SARS-CoV-2 mRNA vaccine candidate in streptozotocin-induced diabetic mice

Hyeong Ho Jo, Subin Yoon, Eunji J. Lee, Inyoung Park et autres

kr, pr (code pays fourni par la source)

Dihydrotricetin from Euonymus hamiltonianus ameliorates neuroinflammation and exhibits neuroprotective effect in LPS-induced microglia

Tianqi Huang, Jae Sik Yu, Gyochang Keum, Hyun Ok Yang

Microglia cells are the initial immune cells regulating neuroinflammation response. Under neuro-degenerative conditions, microglia exhibit as an over-activated phenotype, which generate large amounts of cytokines and inflammatory mediators. Euonymus hamiltonianus Wall. (E. hamiltonianus) showed an effect of enhanced memory and cognitive abilities …

kr (code pays fourni par la source)

Delivery strategies of messenger RNA therapeutics for brain disorders

Kounghwa Youn, Hyo-wook Gil, Yongseok Choi, Gyochang Keum et autres

Abstract Messenger RNA (mRNA) therapeutics have substantial potential in modern medicine, such as brain disorder treatment, following the success of mRNA vaccines against coronavirus disease 2019 (COVID‐19). Their ability to drive endogenous protein production makes them highly versatile, but clinical translation for …

kr (code pays fourni par la source)

Protocol for in vitro transfection of mRNA-encapsulated lipid nanoparticles

Kounghwa Youn, Soyeon Yoo, In Sung Hwang, Hyo-wook Gil et autres

Lipid nanoparticle (LNP) platforms are promising for mRNA therapeutics; however, while highly effective in vivo , commercial mRNA-LNPs show reduced transfection efficiency in vitro under serum-starved conditions, limiting mechanistic studies and cell engineering applications. Here, we present a new standard for in …

kr, jp (code pays fourni par la source)

P35-04 Efforts to Improve Nonclinical Guidelines for Enhancing the Safety of Prophylactic mRNA Vaccines in South Korea

J.-H. Che, Gyochang Keum, Byeong-Cheol Kang, J.W. Yun et autres

kr (code pays fourni par la source)

Artificial intelligence-driven discovery of novel scaffolds for selective TLR7 antagonists and their application in enhancing mRNA translation efficiency

Soyeon Yoo, N K Kim, Gyochang Keum, Hahnbeom Park et autres

Toll-like receptor 7 (TLR7) is crucial in the innate immune response, responsible for recognizing single-stranded RNA from external pathogens and initiating the production of inflammatory cytokines and type I interferons. Despite the potential therapeutic benefits of modulating TLR7 activity, particularly in autoimmune …

kr (code pays fourni par la source)

Novel Less Toxic, Lymphoid Tissue‐Targeted Lipid Nanoparticles Containing a Vitamin B5‐Derived Ionizable Lipid for mRNA Vaccine Delivery (Adv. Healthcare Mater. 7/2025)

Soyeon Yoo, Muhammad Faisal, Seo‐Hyeon Bae, Kounghwa Youn et autres

Vitamin B5-Derived Ionizable Lipid The cover art of article 2403366 by Jae-Hwan Nam, Gyochang Keum, Eun-Kyoung Bang, and co-workers represents the core structure of vitamin B5 using symbolic images of avocado and sunflower seeds alongside its chemical depiction. It illustrates the formation …

Novel N-(3-(1-(4-sulfamoylphenyl)triazol-4-yl)phenyl)benzamide Derivatives as Potent Carbonic Anhydrase Inhibitors with Broad-Spectrum Anticancer Activity: Leveraging Tail and Dual-Tail Approaches

Ashraf Kareem El‐Damasy, Hyun Ji Kim, Muhammad Faisal, Andrea Angeli et autres

Carbonic anhydrases (CAs) IX and XII are crucial for the survival and metastasis of solid tumors under hypoxic conditions. We designed compounds 7a – s, integrating triazole and benzenesulfonamide scaffolds known for inhibiting tumor-associated CAs IX/XII. Initial synthesis included compounds 7a – …

Égypte, kr, ye, it (code pays fourni par la source)

Impact of administration routes and dose frequency on the toxicology of SARS-CoV-2 mRNA vaccines in mice model

Jaehun Ahn, Jisun Lee, Gahyun Roh, Na-Young Lee et autres

The increasing use of SARS-CoV-2 mRNA vaccines has raised concerns about their potential toxicological effects, necessitating further investigation to ensure their safety. To address this issue, we aimed to evaluate the toxicological effects of SARS-CoV-2 mRNA vaccine candidates formulated with four different …

kr, pr (code pays fourni par la source)