Hisataka Aridome

Docosahexaenoic and eicosapentaenoic acids differentially enhance the blood–brain barrier function via distinct PPAR-dependent upregulation of tight junction proteins in brain endothelial cells

Takuro Iwao, Fuyuko Takata, Yasuyoshi Tanaka, Hisataka Aridome et autres

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Docosahexaenoic and eicosapentaenoic acids regulate tight junction-associated protein expression via different peroxisome proliferator-activated receptors in brain endothelial cells

Takuro Iwao, Fuyuko Takata, Yasuyoshi Tanaka, Hisataka Aridome et autres

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Brain Pericytes Enhance MFSD2A Expression and Plasma Membrane Localization in Brain Endothelial Cells Through the PDGF-BB/PDGFRβ Signaling Pathway

Takuro Iwao, Fuyuko Takata, Hisataka Aridome, Miho Yasunaga et autres

The brain actively obtains nutrients through various transporters on brain microvessel endothelial cells (BMECs). Major facilitator superfamily domain–containing protein 2a (MFSD2A) serves as a key transporter of docosahexaenoic acid (DHA) at the blood–brain barrier (BBB) and is exclusively expressed in BMECs. Although …

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α-Synuclein Degradation in Brain Pericytes Is Mediated via Akt, ERK, and p38 MAPK Signaling Pathways

Miki Yokoya, Fuyuko Takata, Takuro Iwao, Junichi Matsumoto et autres

Parkinson's disease (PD) is characterized by widespread distribution of Lewy bodies, which are composed of phosphorylated and aggregated forms of α-Synuclein (α-Syn), in the brain. Although the accumulation and propagation of α-Syn contribute to the development of PD, the involvement of the …

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Aging decreases docosahexaenoic acid transport across the blood-brain barrier in C57BL/6J mice

Takuro Iwao, Fuyuko Takata, Junichi Matsumoto, Hisataka Aridome et autres

Nutrients are actively taken up by the brain via various transporters at the blood-brain barrier (BBB). A lack of specific nutrients in the aged brain, including decreased levels of docosahexaenoic acid (DHA), is associated with memory and cognitive dysfunction. To compensate for …

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Senescence in brain pericytes attenuates blood-brain barrier function in vitro: A comparison of serially passaged and isolated pericytes from aged rat brains

Takuro Iwao, Fuyuko Takata, Junichi Matsumoto, Yuki Goto et autres

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Cyclophillin A is involved in the clathrin-mediated endocytosis of α-synuclein by brain pericytes

Yokoya Miki, Fuyuko Takata, Takuro Iwao, Junichi Matsumoto et autres

Parkinson’s disease (PD) is characterized by widespread distribution of Lewy bodies, which are mainly composed of aggregated α-synuclein(α-Syn), in the brain. We previously revealed that pericytes, one of the blood-brain barrier-constituting cells, take up α-Syn and degrade it. Therefore, an efficient uptake …

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Brain Transport of Docosahexaenoic Acid Across the Blood–Brain Barrier Decreases in Middle-Aged and Aged Mice

Takuro Iwao, Fuyuko Takata, Junichi Matsumoto, Hisataka Aridome et autres

Abstract Background: Nutrients are actively taken up by the brain via various transporters at the blood–brain barrier (BBB). A lack of specific nutrients in the aged brain, including decreased levels of docosahexaenoic acid (DHA), is associated with memory and cognitive dysfunction. To …

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Cyclophillin A is involved in the uptake of oligomericα-synuclein by brain pericytes

Miki Yokoya, Fuyuko Takata, Takuro Iwao, Junichi Matsumoto et autres

Parkinson's disease (PD) is characterized by widespread distribution of Lewy bodies, which are mainly composed of aggregated α-synuclein(α-Syn), in the brain. The ability of glial cells to take up extracellular α-Syn contributes to the wide distribution and accumulation of α-Syn in the …

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Involvement of P-glycoprotein in α-Synuclein aggregate-induced inflammatory mediator release by brain pericytes

Shinya Dohgu, Miki Yokoya, Minami Akizuki, Atsushi Kobayashi et autres

The pathological hallmark of Parkinson disease (PD) is a widespread distribution of the aggregated α-synuclein (α-Syn) proteins in the inclusions known as Lewy bodies. Exogenous α-Syn secreted from neurons could induce neuroinflammation. We previously reported that pericytes, an essential component of the …

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Vonoprazan decreases tight junction-associated proteins at the blood-brain barrier

Sawa Tachibana, Saki Tanaka, Fuyuko Takata, Takuro Iwao et autres

Use of proton pump inhibitors (PPIs) is associated with increased risk of dementia and cognitive impairment. Accumulating evidence indicate that the dysfunction of blood-brain barrier (BBB) in hippocampus was observed in the aged people with prior cognitive impairment, suggesting that BBB dysfunction …

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