Sen Ma

Admixture-driven structural variation diversity and its functional implications

Haiyi Lou, Yimin Wang, Yu Chai, Zhilin Ning et autres

ABSTRACT Population admixture is a potent evolutionary force shaping genomic diversity, yet its influence on the dynamics and functional consequences of structural variation (SV) remains poorly understood. Here, we present a comprehensive whole-genome sequencing analysis of SVs in the Uyghurs, a model …

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Reconstructing the ancestral gene pool to uncover the origins and genetic links of Hmong–Mien speakers

Yang Gao, Xiaoxi Zhang, Hao Chen, Yan Lü et autres

BACKGROUND: Hmong-Mien (HM) speakers are linguistically related and live primarily in China, but little is known about their ancestral origins or the evolutionary mechanism shaping their genomic diversity. In particular, the lack of whole-genome sequencing data on the Yao population has prevented …

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A pangenome reference of 36 Chinese populations

Yang Gao, Xiaofei Yang, Hao Chen, Xinjiang Tan et autres

Abstract Human genomics is witnessing an ongoing paradigm shift from a single reference sequence to a pangenome form, but populations of Asian ancestry are underrepresented. Here we present data from the first phase of the Chinese Pangenome Consortium, including a collection of …

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PGG.MHC: toward understanding the diversity of major histocompatibility complexes in human populations

Xiaohan Zhao, Sen Ma, Baonan Wang, Xuetong Jiang

The human leukocyte antigen (HLA) system, or the human version of the major histocompatibility complex (MHC), is known for its extreme polymorphic nature and high heterogeneity. Taking advantage of whole-genome and whole-exome sequencing data, we developed PGG.MHC to provide a platform to …

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A Pangenome Reference of 36 Chinese populations

Shuhua Xu, Yang Gao, Xiaofei Yang, Hao Chen et autres

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Haplotype-resolved de novo assembly of a Tujia genome suggests the necessity for high-quality population-specific genome references

Haiyi Lou, Yang Gao, Bo Xie, Yimin Wang et autres

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Sliding-Window Based Batch Forwarding using Intra-Flow Random Linear Network Coding

Sen Ma, Xiulian Liu, Yan Yan, Baoxian Zhang et autres

Batch forwarding using intra-flow random linear network coding (RLNC) has been used to improve the performance of a wireless network constituent of lossy links. However, existing batch-based forwarding mechanisms in this aspect can lead to a lot of bandwidth waste and thus …

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Additional file 2: of Whole-genome bisulfite sequencing of goat skins identifies signatures associated with hair cycling

Chao Li, Yán Li, Guangxian Zhou, Ye Gao et autres

Table S1. Methylated cytosines in the skins at anagen and telogen stages. Table S2. The proportion of methylated cytosines in goat skins at anagen and telogen stages. Table S3. The identified DMRs through WGBS and the annotated genes. Table S4. GO biological …