Nicolas Blanchard

Monitoring HLA-A2-Restricted T-Cell Responses and BCLA-Specific Serostatus During Human Latent Toxoplasma gondii Infection Suggests the Implication of CD8+ T Cells in Parasite Containment

R Romieu-Mourez, Pierre Emmanuel Paulet, Emilie Bassot, Arthur Palak et autres

BACKGROUND: T cells are critical to control Toxoplasma gondii (T. gondii) parasite infection. Yet, our understanding of T. gondii-specific CD8+ T cell responses in humans remains scarce. Here, we studied 56 HLA-A2+ healthy blood donors, including 40 latently infected subjects. METHODS: In …

fr (code pays fourni par la source)

Toxoplasma gondii infection and chronic IL-1 elevation drive hippocampal DNA double-strand break signaling, leading to cognitive deficits

Marcy Belloy, Benjamin A. M. Schmitt, Florent H. Marty, Charlotte Paut et autres

fr (code pays fourni par la source)

Tissue-resident memory CD4 + T cells infiltrate the CNS in progressive multiple sclerosis and contribute to chronic autoimmunity in mice

Aurora Pignata, David Frieser, Carmen Gonzalez-Fierro, Cheng‐Chih Hsiao et autres

Preventing T cell migration to the central nervous system (CNS) has remarkable therapeutic effects in relapsing-remitting multiple sclerosis (RRMS) but is poorly effective against the progressive form (PMS). Disability progression in PMS likely results from an interplay between smoldering local inflammation and …

fr, nl, pt (code pays fourni par la source)

Tissue-resident memory CD4+ T cells infiltrate the CNS in progressive multiple sclerosis and contribute to chronic autoimmunity in mice

Aurora Pignata, David Frieser, Carmen Gonzalez-Fierro, Cheng‐Chih Hsiao et autres

International audience

fr, nl, us (code pays fourni par la source)

Id2 levels determine the development of effector vs. exhausted tissue-resident memory CD8+ T cells during CNS chronic infection

Aboubacar Sidiki K. Coulibaly, Lucie Nozeran, Céline Thomann, Marine Alis et autres

Coulibaly et al. found that the expression level of the transcriptional regulator Id2 dictates brain CD8 Trm functional states during chronic Toxoplasma gondii infection. Id2 deficiency reduces Trm effector functions and tissue-retention molecule expression and promotes Trm exhaustion, while its overexpression limits …

fr (code pays fourni par la source)

Toxoplasma gondii chronic infection decreases visceral nociception through peripheral opioid receptor signaling

Alexis Audibert, Xavier Mas‐Orea, Léa Rey, Marcy Belloy et autres

By eliciting immune activation in the digestive tract, intestinal pathogens may perturb gut homeostasis. Some gastrointestinal infections can indeed increase the risk of developing post-infectious irritable bowel syndrome (PI-IBS). Intriguingly, the prevalent foodborne parasite Toxoplasma gondii has not been linked to the …

fr (code pays fourni par la source)

Dendritic cell phagosomes recruit GRASP55 for export of antigen-loaded MHC molecules

Ignacio Cebrián, Sofía Dinamarca, Elena Priego, Nathalie Brouwers et autres

T cells. A critical but poorly understood step in this process is the trafficking of peptide-loaded MHC molecules from the endocytic system to the cell surface. In this study, we demonstrate that the Golgi reassembly-stacking protein of 55 kDa (GRASP55), which has …

ar, es, de, fr (code pays fourni par la source)

SNX17 Regulates Antigen Internalisation and Phagosomal Maturation by Dendritic Cells

Sofía Dinamarca, Cristina Croce, Anna Salvioni, Facundo Mendes Garrido et autres

Antigen cross-presentation is the process whereby small peptides derived from exogenous antigens are attached to MHC-I molecules triggering CD8+ T lymphocyte activation. The endocytic route of dendritic cells (DCs) is highly specialised for cross-presentation to initiate cytotoxic immune responses against numerous intracellular …

ar, fr, es (code pays fourni par la source)

Toxoplasma gondii chronic infection decreases visceral nociception through peripheral opioid receptor signaling

Alexis Audibert, Xavier Mas‐Orea, Léa Rey, Marcy Belloy et autres

Abstract By eliciting immune activation in the digestive tract, intestinal pathogens may perturb gut homeostasis. Some gastrointestinal infections can indeed increase the risk of developing post-infectious irritable bowel syndrome (PI-IBS). Intriguingly, the prevalent foodborne parasite Toxoplasma gondii has not been linked to …

fr (code pays fourni par la source)

Author response: Enkephalin-mediated modulation of basal somatic sensitivity by regulatory T cells in mice

Nicolas Aubert, Madeleine Purcarea, Julien Novarino, Julien Schopp et autres

fr (code pays fourni par la source)

Id2 levels determine the development of effector vs. exhausted tissue-resident memory CD8 + T cells during CNS chronic infection

Aboubacar Sidiki K. Coulibaly, Lucie Nozeran, Céline Thomann, Marine Alis et autres

ABSTRACT Tissue-resident memory T cells (Trm) are essential for regional immunity in non-lymphoid tissues. Although single-cell transcriptomics have revealed Trm heterogeneity in various diseases, the molecular mechanisms behind this diversity are unclear. To investigate this, we used Toxoplasma gondii ( T. gondii …

fr (code pays fourni par la source)

Enkephalin-mediated modulation of basal somatic sensitivity by regulatory T cells in mice

Nicolas Aubert, Madeleine Purcarea, Julien Novarino, Julien Schopp et autres

CD4 + CD25 + Foxp3 + regulatory T cells (Treg) have been implicated in pain modulation in various inflammatory conditions. However, whether Treg cells hamper pain at steady state and by which mechanism is still unclear. From a meta-analysis of the transcriptomes …

fr (code pays fourni par la source)