Sofía Dinamarca

Dendritic cell phagosomes recruit GRASP55 for export of antigen-loaded MHC molecules

José Ignacio Cebrián, Sofía Dinamarca, María Jesús Pena Rodríguez, Elena Priego et autres

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Dendritic cell phagosomes recruit GRASP55 for export of antigen-loaded MHC molecules

Ignacio Cebrián, Sofía Dinamarca, Elena Priego, Nathalie Brouwers et autres

T cells. A critical but poorly understood step in this process is the trafficking of peptide-loaded MHC molecules from the endocytic system to the cell surface. In this study, we demonstrate that the Golgi reassembly-stacking protein of 55 kDa (GRASP55), which has …

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SNX17 Regulates Antigen Internalisation and Phagosomal Maturation by Dendritic Cells

Sofía Dinamarca, Cristina Croce, Anna Salvioni, Facundo Mendes Garrido et autres

Antigen cross-presentation is the process whereby small peptides derived from exogenous antigens are attached to MHC-I molecules triggering CD8+ T lymphocyte activation. The endocytic route of dendritic cells (DCs) is highly specialised for cross-presentation to initiate cytotoxic immune responses against numerous intracellular …

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Kinetics of antigen cross-presentation assessed experimentally and by a model of the complete endomembrane system

F. Nieto, Facundo Mendes Garrido, Sofía Dinamarca, Ignacio Cebrián et autres

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Efficient Cholesterol Transport in Dendritic Cells Defines Optimal Exogenous Antigen Presentation and Toxoplasma gondii Proliferation

Cristina Croce, Facundo Mendes Garrido, Sofía Dinamarca, Julien Santi‐Rocca et autres

Dendritic cells are the most powerful antigen-presenting cells of the immune system. They present exogenous antigens associated with Major Histocompatibility Complex (MHC) Class II molecules through the classical pathway to stimulate CD4+ T cells, or with MHC-I to activate CD8+ T lymphocytes …

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SNX17 regulates antigen internalization and phagosomal maturation by dendritic cells

Ignacio Cebrián, Sofía Dinamarca, Cristina Croce, Anna Salvioni et autres

Abstract Cross-presentation is the process whereby antigenic peptides derived from exogenous antigens are associated to MHC class I molecules triggering the activation of CD8+ T lymphocytes. The endocytic route of dendritic cells (DCs) is strongly specialized to achieve antigen cross-presentation efficiently, which …

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