Rachael C. Crew

Maternal cardiometabolic dysfunction and fetal sex‐specific alterations to uterine vascular reactivity in an ovine model of obesity during pregnancy

Rachael C. Crew, Anna L. K. Cochrane, 牛有国, Sage G. Ford et autres

Obesity during pregnancy is at pandemic proportions and predisposes women to pre- and postnatal cardiovascular dysfunction. The mechanisms underlying this maternal cardiovascular vulnerability remain unclear, partly due to a lack of translatable models capable of longitudinal in vivo cardiovascular monitoring. Here, we …

au, gb (code pays fourni par la source)

MiR ‐21‐5p Protects Embryonic Growth and Heart Function During Developmental Hypoxia by Dampening HIF Responses and Altering Gene Expression

Bernardo J. Krause, Ximena Calle, Ranya V. Kumar, 牛有国 et autres

ABSTRACT Fetal hypoxia is a common complication of pregnancy and increases the cardiovascular risk in offspring, contributing to a significant burden on life‐long health. Preventative strategies against its adverse effects have focused on targeting oxidative stress, but not epigenetic mechanisms. Since miRNA‐21‐5p …

cl, gb, au, pt (code pays fourni par la source)

MiR-21-5p Protects Embryonic Growth and Heart Function During Developmental Hypoxia by Dampening HIF Responses and Altering Gene Expression.

Bernardo Krause, Ximena Calle, Ranya V. Kumar, 牛有国 et autres

Fetal hypoxia is a common complication of pregnancy and increases the cardiovascular risk in offspring, contributing to a significant burden on life-long health. Preventative strategies against its adverse effects have focused on targeting oxidative stress, but not epigenetic mechanisms. Since miRNA-21-5p downregulation …

MiR ‐21‐5p Protects Embryonic Growth and Heart Function During Developmental Hypoxia by Dampening HIF Responses and Altering Gene Expression

Bernardo J Krause, Ximena Calle, Ranya V. Kumar, 牛有国 et autres

Publication status: Published

Maternal cardiometabolic dysfunction and fetal sex-specific alterations to uterine vascular reactivity in an ovine model of diet-induced obesity during pregnancy

Rachael C. Crew, A. G. COCHRANE, Youguo Niu, Sage G. Ford et autres

Abstract Obesity during pregnancy is at pandemic proportions and predisposes women to pre- and postnatal cardiovascular dysfunction. The mechanisms underlying this maternal cardiovascular vulnerability remain unclear, partly due to a lack of translatable models capable of longitudinal in vivo cardiovascular monitoring. Here, …

au, gb, us (code pays fourni par la source)

Epigenetic regulation of the fetal circadian clock: Implications for nutritional programming of circadian and metabolic function

Rachael C. Crew, Peter J. Mark, Brendan J. Waddell

au (code pays fourni par la source)

Contributors

Seán T. Anderson, Olivia S. Anderson, Aneta Balcerczyk, Aarya Bavare et autres

Deciphering the role of placental stress in modulating fetal growth restriction and maternal maladaptations to pregnancy

Hong Wa Yung, Rachael C. Crew, Noa Hasky, Sophie Dargan et autres

gb (code pays fourni par la source)

Pilot investigations into the mechanistic basis for adverse effects of glucocorticoids in dysferlinopathy

Erin M. Lloyd, Rachael C. Crew, Vanessa Haynes, Robert B. White et autres

BACKGROUND: Dysferlinopathies are a clinically heterogeneous group of muscular dystrophies caused by gene mutations resulting in deficiency of the membrane-associated protein dysferlin. They manifest post-growth and are characterised by muscle wasting (primarily in the limb and limb-gridle muscles), inflammation, and replacement of …

au, gb (code pays fourni par la source)

An ovine model for investigation of the microenvironment of the male mammary gland

B Davies, Rachael C. Crew, A. Cochrane, Katie Davies et autres

The specific biology of the male breast remains relatively unexplored in spite of the increasing global prevalence of male breast cancer. Delineation of the microenvironment of the male breast is restricted by the low availability of human samples and a lack of …

gb, au (code pays fourni par la source)

An ovine model for investigation of the microenvironment of the male mammary gland

B Davies, Rachael C. Crew, A. Cochrane, Katie Davies et autres

Abstract The specific biology of the male breast remains relatively unexplored in spite of the increasing global prevalence of male breast cancer. Delineation of the microenvironment of the male breast is restricted by the low availability of human samples and a lack …

gb, ca (code pays fourni par la source)

Structural changes in feto-placental arteries of growth-restricted rats prevent the normal deceleration of blood flow to the capillary bed.

Nikhilesh Bappoo, Yutthapong Tongpob, Rachael C. Crew, Lachlan J. Kelsey et autres

au (code pays fourni par la source)