Jonathan Carlson

Real-world Outcomes Using DBS Systems with Directionality and Multiple Independent Current Control: USA Experience (P1-17.008)

Michael S. Okun, Kelly D. Foote, Theresa Zesiewicz, Yarema B. Bezchlibnyk et autres

Here, we describe evaluation of real-world outcomes of Parkinson’s disease (PD) patients treated with directional Deep Brain Stimulation (DBS) systems using Multiple Independent Current Control (MICC ) at multiple U.S. centers.

us, sk, ca, in, nl, ie (code pays fourni par la source)

Targeting cancer-associated fibroblasts for real-time intraoperative tumor identification with a spray-on fluorescent probe

Riley J. Deutsch, Yuxuan Xie, Zachary M. Rabinowitz, Marie A. Goemans et autres

Surgical tumor resection is often the only curative option for the nearly 20 million newly diagnosed patients with cancer every year. Fluorescence-guided surgery techniques are being developed in an effort to improve margin detection and surgical resection outcomes, with several systemically administered …

us, ch (code pays fourni par la source)

93 Spatial analysis of head and neck squamous cell cancer tumor microenvironment identifies predictors of pembrolizumab therapy

Juhyun Oh, Jan Hoelzl, Jonathan Carlson, Ruben Bill et autres

Background Immune checkpoint inhibitors such as pembrolizumab offer a therapeutic option for head and neck squamous cell carcinoma (HNSCC), yet only a minority of patients benefit. Although PD-L1 expression and the combined positive score (CPS) are used as biomarkers for patient selection, …

us, ch (code pays fourni par la source)

ID# 1884679 Clinical Outcomes Using DBS Systems with Directionality and Multiple Independent Current Control: Real-World, USA Experience

Michael S. Okun, Kelly D. Foote, Theresa Zesiewicz, Yarema B. Bezchlibnyk et autres

us, ca, nl (code pays fourni par la source)

Sequential Diagnosis with Language Models

Harsha Nori, Mayank Daswani, Christopher Kelly, Scott Lundberg et autres

Artificial intelligence holds great promise for expanding access to expert medical knowledge and reasoning. However, most evaluations of language models rely on static vignettes and multiple-choice questions that fail to reflect the complexity and nuance of evidence-based medicine in real-world settings. In …

Building a Medicinal Chemistry Framework for Bioorthogonal Probes

Markus Staudt, Jonathan Carlson

Screening the tetrazine-protein interactome finds the balance needed for high-performance fluorescent probes.

dk, at, us (code pays fourni par la source)

Spatial analysis identifies DC niches as predictors of pembrolizumab therapy in head and neck squamous cell cancer

Juhyun Oh, Jan Hoelzl, Jonathan Carlson, Ruben Bill et autres

dendritic cells (DCs) in niches better predicts overall patient survival than CPS alone. This study highlights the importance of understanding the spatial context of immune networks for immunotherapy.

us, de, ch (code pays fourni par la source)

Next-Level Bioorthogonal Bond-Cleavage Through Intramolecular Control of Click-To-Release Chemistry

Walter Kuba, Andrea Schiefer, Andreas Löffler, Nicole Houszka et autres

Bioorthogonal bond-cleavage reactions are powerful tools for investigating biological dynamics and advancing therapeutic strategies. Primed by click reactivity, the multi-step cascades that lead to bioorthogonal release have nevertheless been challenging to navigate. For the widely recognized tetrazine-triggered cleavage of trans-cyclooctenes (TCO), the …

at, us (code pays fourni par la source)

Platelet-white cell ratio is more strongly associated with mortality than other common risk ratios derived from complete blood counts

Brody H. Foy, Jonathan Carlson, Aaron D. Aguirre, John M. Higgins

Complete blood count indices and their ratios are associated with adverse clinical outcomes for many acute illnesses, but the mechanisms generating these associations are not fully understood. Recent identification of a consistent pattern of white blood cell and platelet count co-regulation during …

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P070 REAL-WORLD OUTCOMES USING DBS SYSTEMS WITH DIRECTIONALITY AND MULTIPLE INDEPENDENT CURRENT CONTROL: USA EXPERIENCE

Michael S. Okun, Kelly D. Foote, Theresa Zesiewicz, Yarema B. Bezchlibnyk et autres

us (code pays fourni par la source)

P056 ASSESSMENT OF IMAGE-GUIDED PROGRAMMING (IGP) ON BILATERAL STN AND GPI DEEP BRAIN STIMULATION PROGRAMMING TIME

Jason L. Aldred, Theresa A. Zesiewicz, Michael S. Okun, Juan Ramirez‐Castaneda et autres

us (code pays fourni par la source)

Cover Picture: Transforming Aryl‐Tetrazines into Bioorthogonal Scissors for Systematic Cleavage of trans‐Cyclooctenes (Angew. Chem. Int. Ed. 5/2025)

Martin Wilkovitsch, Walter Kuba, Patrick Keppel, Barbara Sohr et autres

Bioorthogonal bond-cleavage reactions enable precise control of (bio)molecular function in biological systems. In their Research Article (e202411707), Hannes Mikula et al. report the development of “yellow” hydroxyaryl-tetrazines as bioorthogonal tools for efficient click-to-release of trans-cyclooctenes. The cover picture illustrates the transformation of …

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