Irene Campoy

1179P WomEC: a novel diagnostic test for the detection of endometrial cancer in uterine fluids

Antonio Gil‐Moreno, J. Carvajal, E. Coll de la Rubia, Ángel García et autres

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568 WomEC, a novel diagnostic test for the detection of endometrial cancer in uterine fluids

J.M. Sánchez Carvajal, Eva Coll-de la Rubia, A. Vázquez García, Maria De Martí et autres

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STAT3 phosphorylation at serine 727 activates specific genetic programs and promotes clear cell renal cell carcinoma (ccRCC) aggressiveness

J. Arévalo, Irene Campoy, M. Durán, Stéphane Nemours et autres

The signal transducer and activator of transcription 3 (STAT3) is a transcription factor mainly activated by phosphorylation in either tyrosine 705 (Y705) or serine 727 (S727) residues that regulates essential processes such as cell differentiation, apoptosis inhibition, or cell survival. Aberrant activation …

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Advances in endometrial cancer protein biomarkers for use in the clinic

Elena Martínez-García, Carlos López-Gil, Irene Campoy, Júlia Vallvé-Juanico et autres

INTRODUCTION: Endometrial cancer (EC) is the fourth most common cancer in women in developed countries. The identification of sensitive and specific biomarkers to improve early detection of EC is crucial for an appropriate management of this disease, in which 30% of patients …

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Genetic analysis of uterine aspirates improves the diagnostic value and captures the intra-tumor heterogeneity of endometrial cancers

Alba Mota, Eva Colás, Pablo García‐Sanz, Irene Campoy et autres

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Abstract 162: Genomic analysis of uterine aspirates improves diagnosis and captures the intratumor heterogeneity in endometrial cancer

Alba Mota, Eva Colás, Pablo García‐Sanz, Irene Campoy et autres

Abstract Background: Endometrial cancer (EC) is the most common cancer in female genital tract in developed countries. Although the majority of ECs are diagnosed in early stages, with a 5-year overall survival of around 80%, an early detection of these tumors is …

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Characterization of Unrelated Clinical Legionella Pneumophila Isolates in Catalonia by Monoclonal Subgrouping and Sequence-Based Typing

Marian García-Núñez, Sara Quero, María Lluisa Pedro-Botet, Irene Barrabeig et autres

AIM: To characterize the genetic diversity of unrelated Legionella pneumophila clinical isolates in Catalonia and compare with other European regions. METHODS: 95 unrelated isolates were analyzed using monoclonal antibodies and sequence-based typing, 1989-2013. RESULTS: The isolates showed a high diversity (IOD 0.964) …

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Exosome-like vesicles in uterine aspirates: a comparison of ultracentrifugation-based isolation protocols

Irene Campoy, Lucía Lanau, Tatiana Altadill, Tamara Sequeiros et autres

BACKGROUND: Uterine aspirates are used in the diagnostic process of endometrial disorders, yet further applications could emerge if its complex milieu was simplified. Exosome-like vesicles isolated from uterine aspirates could become an attractive source of biomarkers, but there is a need to …

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Enabling Metabolomics Based Biomarker Discovery Studies Using Molecular Phenotyping of Exosome-Like Vesicles

Tatiana Altadill, Irene Campoy, Lucía Lanau, Kirandeep Gill et autres

Identification of sensitive and specific biomarkers with clinical and translational utility will require smart experimental strategies that would augment expanding the breadth and depth of molecular measurements within the constraints of currently available technologies. Exosomes represent an information rich matrix to discern …

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MOESM2 of Exosome-like vesicles in uterine aspirates: a comparison of ultracentrifugation-based isolation protocols

Irene Campoy, Lucía Lanau, Tatiana Altadill, Tamara Sequeiros et autres

Additional file 2: Figure S1. Size distribution of isolated MVs, all of them collected at the same point in each protocol.

MOESM1 of Exosome-like vesicles in uterine aspirates: a comparison of ultracentrifugation-based isolation protocols

Irene Campoy, Lucía Lanau, Tatiana Altadill, Tamara Sequeiros et autres

Additional file 1: Table S1. Clinical and pathological features of patients. Age, diagnosis and starting volume of uterine aspirates’ fluid fraction are detailed. Samples 1-27 were pooled to compare EVs isolation protocols; samples 28-33 were individually used for EVs characterization by NTA …

MOESM6 of Exosome-like vesicles in uterine aspirates: a comparison of ultracentrifugation-based isolation protocols

Irene Campoy, Lucía Lanau, Tatiana Altadill, Tamara Sequeiros et autres

Additional file 6: Figure S5. Concentration and quality of RNA derived from each individual uterine aspirate was analyzed with an Agilent Bioanalyzer.