Daniel Kovarsky

Publisher Correction: Tumor transcriptional state predicts survival in immune-checkpoint-blockade-treated glioblastoma

Jack Y. Ghannam, Julian Bryan, Jakob Weiss, Daniel Kovarsky et autres

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Tumor transcriptional state predicts survival in immune-checkpoint-blockade-treated glioblastoma

Jack Y. Ghannam, Julian Bryan, Jakob Weiss, Daniel Kovarsky et autres

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A personalized neoantigen vaccine to reprogram the immune landscape of glioblastoma.

Jack Y. Ghannam, Daniel Kovarsky, Laine Marrah, Landon Oetjen et autres

2006 Background: Glioblastoma (GBM) remains uniformly lethal despite standard therapy. An immunosuppressive tumor microenvironment (TME) and limited T cell infiltration pose major barriers to immunotherapy. Personalized neoantigen vaccines offer a strategy to prime tumor-specific T cell responses by targeting patient-specific mutations, driving …

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Abstract 7743: Pre-existing T cells drive durable anti-tumor immunity after oncolytic virus therapy in glioblastoma

Maxime Meylan, Ye Tian, Lijian Wu, Alexander Ling et autres

Abstract Background: Recurrent glioblastoma (rGBM) remains refractory to immunotherapy due to sparse and suppressed T cell infiltration. We recently reported that survival correlated with immune activation signatures in rGBM patients receiving the oncolytic HSV-1 (oHSV) rQNestin34.5v.2 (CAN-3110). Here, we provide in-situ and …

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Persistent T cell activation and cytotoxicity against glioblastoma following single oncolytic virus treatment in a clinical trial

Maxime Meylan, Ye Tian, Lijian Wu, Alexander Ling et autres

A recent first-in-human clinical trial demonstrated that survival in glioblastoma (GBM) patients following rQNestin34.5v.2 oncolytic virus treatment was associated with immune activation signatures. This study was registered at ClinicalTrials.gov (NCT03152318). Here, we provide in situ evidence of ongoing T cell-mediated cytotoxicity against …

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Cefazolin-induced coagulopathy: a case report

Olivier Zerbib, Daniel Kovarsky, Michael Oshrov, lev Shaoul

OBJECTIVE: We report a case of cefazolin-induced coagulopathy, highlighting the importance of maintaining a high index of suspicion for this rare adverse effect of cefazolin. SETTING: Department of intensive care, Rabin Medical Center, Hasharon Hospital, Petach Tikvah, Israel. PATIENT: A patient presented …

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Emerging clinical applications of single-cell RNA sequencing in oncology

Emily Boxer, Nisan Feigin, Roi Tschernichovsky, Noam Galili Darnell et autres

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Clinical trial links oncolytic immunoactivation to survival in glioblastoma

Alexander Ling, Isaac H. Solomon, Ana Montalvo Landivar, Hiroshi Nakashima et autres

Abstract Immunotherapy failures can result from the highly suppressive tumour microenvironment that characterizes aggressive forms of cancer such as recurrent glioblastoma (rGBM) 1,2 . Here we report the results of a first-in-human phase I trial in 41 patients with rGBM who were …

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Hallmarks of transcriptional intratumour heterogeneity across a thousand tumours

Avishai Gavish, Michael P. H. Tyler, Alissa Greenwald, Rouven Hoefflin et autres

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Multiple Recurrent Pneumothoraces and Thoracic Drain Insertion in a Mechanically Ventilated Patient Suffering from Methadone Induced Cardiomyopathy

Olivier Zerbib, Yaniv Hadi, Daniel Kovarsky, Gal Sahaf Levin et autres

Objective: To describe the experience of a multimodal therapeutic approach in a patient with methadone-induced dilated cardiomyopathy who developed recurrent bilateral tension pneumothorax. Setting: Department of Intensive Care. Patient: A patient with methadone-induced cardiomyopathy and severe left ventricular dysfunction who after mechanical …

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Effectiveness of intra-venous steroids for preventing surgery for lumbo-sacral radiculopathy secondary to intervertebral disc herniation: a retrospective study of 213 patients

Daniel Kovarsky, Adi Shani, Alon Rod, Dan Ciubotaru et autres

The natural history of lumbar disc herniation with radiculopathy is favorable, with 95% of patients expected to be pain-free within 6 months of onset. Despite the favorable prognosis, operative treatment is often chosen by patients unable to "ride out" the radicular episode. …

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The transcriptional hallmarks of intra-tumor heterogeneity across a thousand tumors

Avishai Gavish, Michael P. H. Tyler, Dor Simkin, Daniel Kovarsky et autres

Abstract Each tumor contains malignant cells that differ in genotype, phenotype, and in their interactions with the tumor micro-environment (TME). This results in distinct integrated cellular states that govern intra-tumor heterogeneity (ITH), a central challenge of cancer therapeutics. Dozens of recent studies …

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