Fumiji Saito

An optimized cocktail of small molecule inhibitors promotes the maturation of dendritic cells in GM-CSF mouse bone marrow culture

Shintaro Matsuba, Hiroki Ura, Fumiji Saito, Chie Ogasawara et autres

Dendritic cells (DCs) are the most potent antigen-presenting cells, playing an essential role in the pathogen and tumor recognition, and anti-tumor immunity, and linking both the innate and adaptive immunity. The monocyte-derived DCs generated by ex vivo culture, have been used for …

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PCBP1 acts as a regulator of CCL2 expression in macrophages to induce recruitment of monocyte-derived macrophages into the inflamed colon

Xinquan Yang, Toshiki Yabe‐Wada, Jia Han, Fumiji Saito et autres

Intestinal macrophages with functional plasticity play essential roles in gut immune responses by increasing chemokines and cytokines, thereby contributing to the pathogenesis of inflammatory bowel disease (IBD). Poly(rC)-binding protein 1 (PCBP1), which is widely expressed in immune cells, binds to nucleic acids …

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Plasmodium falciparum RIFIN is a novel ligand for inhibitory immune receptor LILRB2

Akihito Sakoguchi, Fumiji Saito, Kouyuki Hirayasu, Kyoko Shida et autres

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Erratum: Corrigendum: Immune evasion of Plasmodium falciparum by RIFIN via inhibitory receptors

Fumiji Saito, Kouyuki Hirayasu, Takeshi Satoh, Christian William Wang et autres

Immune evasion of Plasmodium falciparum by RIFIN via inhibitory receptors

Fumiji Saito, Kouyuki Hirayasu, Takeshi Satoh, Christian William Wang et autres

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Myeloperoxidase/HLA Class II Complexes Recognized by Autoantibodies in Microscopic Polyangiitis

Ryosuke Hiwa, Koichiro Ohmura, Noriko Arase, Hui Jin et autres

OBJECTIVE: Autoantibodies against myeloperoxidase (MPO) that are expressed in neutrophils play an important role in the pathogenesis of microscopic polyangiitis (MPA). We recently observed that misfolded cellular proteins are transported to the cell surface by HLA class II molecules and are targeted …

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Microbially cleaved immunoglobulins are sensed by the innate immune receptor LILRA2

Kouyuki Hirayasu, Fumiji Saito, Tadahiro Suenaga, Kyoko Shida et autres

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FRI0345 Autoantibodies in Rheumatoid Arthritis Specifically Recognize Igg Heavy Chain Complexed with Hla-Dr, Which is Strongly Associated with Rheumatoid Arthritis Susceptibility

Hui Jin, Noriko Arase, K. Hirayasu, Masanori Kohyama et autres

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Autoantibodies to IgG/HLA class II complexes are associated with rheumatoid arthritis susceptibility

Hui Jin, Noriko Arase, Kouyuki Hirayasu, Masako Kohyama et autres

Specific HLA class II alleles are strongly associated with susceptibility to rheumatoid arthritis (RA); however, how HLA class II regulates susceptibility to RA has remained unclear. Recently, we found a unique function of HLA class II molecules: their ability to aberrantly transport …

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Inefficient phagosome maturation in infant macrophages

Fumiji Saito, Hirotaka Kuwata, Eiji Oiki, Masato Koike et autres

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Regulation of IL-27p28 gene by lipopolysaccharide in dendritic DC2.4 cells

Maki Kamakura, Keiko Morisawa, Hideyuki Komi, Ayako Tomatani et autres

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Corrigendum to “Role of IL-27-producing dendritic cells in Th1-immunity polarization in Lewis rats” [Biochem. Biophys. Res. Commun. 338 (2005) 1773–1778]

Fumiji Saito, Yoshinori Ohno, Keiko Morisawa, Maki Kamakura et autres