Eiji Oiki

CAPS1 RNA Editing Promotes Dense Core Vesicle Exocytosis

Kotaro Miyake, Toshio Ohta, Hisako Nakayama, Nobutaka Doe et autres

Calcium-dependent activator protein for secretion 1 (CAPS1) plays a distinct role in the priming step of dense core vesicle (DCV) exocytosis. CAPS1 pre-mRNA is known to undergo adenosine-to-inosine RNA editing in its coding region, which results in a glutamate-to-glycine conversion at a …

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A Development of Nucleic Chromatin Measurements as a New Prognostic Marker for Severe Chronic Heart Failure

Machiko Matsui Kanzaki, Yoshihiro Asano, Hatsue Ishibashi‐Ueda, Eiji Oiki et autres

BACKGROUND: Accurate prediction of both mortality and morbidity is of significant importance, but it is challenging in patients with severe heart failure. It is especially difficult to detect the optimal time for implanting mechanical circulatory support devices in such patients. We aimed …

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HIG1, a novel regulator of mitochondrial γ‐secretase, maintains normal mitochondrial function

Hiroki Hayashi, Hironori Nakagami, M Takeichi, Munehisa Shimamura et autres

The γ‐secretase complex (which contains presenilins, nicastrin, anterior pharynx defective‐1, and presenilin enhancer‐2) cleaves type I transmembrane proteins, including Notch and amyloid precursor protein. Dysregulated γ‐secretase activity has been implicated in the pathogenesis of Alzheimer's disease, stroke, atherosclerosis, and cancer. Tight regulation …

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Assembly Mechanism of FCT Region Type 1 Pili in Serotype M6 Streptococcus pyogenes

Masanobu Nakata, Keiji Richard Kimura, Tomoko Sumitomo, Satoshi Wada et autres

The human pathogen Streptococcus pyogenes produces diverse pili depending on the serotype. We investigated the assembly mechanism of FCT type 1 pili in a serotype M6 strain. The pili were found to be assembled from two precursor proteins, the backbone protein T6 …

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Pili of oral Streptococcus sanguinis bind to salivary amylase and promote the biofilm formation

Nobuo Okahashi, Masanobu Nakata, Yutaka Terao, Ryutaro Isoda et autres

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Inefficient phagosome maturation in infant macrophages

Fumiji Saito, Hirotaka Kuwata, Eiji Oiki, Masato Koike et autres

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High-efficacy site-directed drug delivery system using sialyl-Lewis X conjugated liposome

Noriyasu Hashida, Nobuyuki Ohguro, Noboru Yamazaki, Yukio Arakawa et autres

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Zinc-deficiency increases infarct size following permanent middle cerebral artery occlusion in rats

Zhen He, Masayasu Matsumoto, Li Cui, Jiyao Li et autres

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Calpain activation in plasma membrane bleb formation during tert-butyl hydroperoxide-induced rat hepatocyte injury

Hideyuki Miyoshi, Koji Umeshita, Masato Sakon, Shinobu Imajoh‐Ohmi et autres

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Involvement of protein phsophatase‐1 in cytoskeletal organization of cultured endothelial cells

Nobutoshi Shinoki, Masato Sakon, Junichi Kambayashi, Masataka Ikeda et autres

The phosphorylation and dephosphorylation of cytoskeletal proteins regulate the shape of eukaryotic cells. To elucidate the role of serine/threonine protein phosphatases (PP) in this process, we studied the effects of calyculin A (CLA), a potent and specific inhibitor of protein phosphatases 1 …

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Suppression by antithrombotic agents of pseudointimal hyperplasia of polytetrafluoroethylene graft implanted into venous system

Junichi Kambayashi, Makoto WATASE, Takashi Shibuya, Tomio Kawasaki et autres

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The role of protein phosphorylation and cytoskeletal reorganization in microparticle formation from the platelet plasma membrane

Yoshiko Yano, Junichi Kambayashi, Eiichi Shiba, Masato Sakon et autres

Platelets activated by various agonists produce vesicles (microparticles; MPs) from the plasma membrane. However, the mechanism of this MP formation remains to be elucidated. To investigate the possible involvement of protein phosphorylation and cytoskeletal reorganization in MP formation, the effects of various …

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