Abstract LT01: Identifying Optimal Tumour-specific Promoters for CRISPR/Cas9 Engineering of Armoured CAR T Cells with Enhanced Safety and Efficacy
Kah Min Yap, Amanda X. Y. Chen, Imran G. House, Phillip K. Darcy et autres
0 citationsCancer Research
Amanda X. Y. Chen
Informations fournies par OpenAlex. Research Africa ne déduit ni nationalité, ni poste, ni coordonnées personnelles.
15Publications signalées
1935Citations signalées
2Affiliations récentes
Institutions déclarées
Domaines associés
CAR-T cell therapy researchImmune Cell Function and InteractionCRISPR and Genetic EngineeringViral Infectious Diseases and Gene Expression in InsectsImmunotherapy and Immune Responses
Publications récentes
Tumor site-directed A1R expression enhances CAR T cell function and improves efficacy against solid tumors
Kevin Sek, Amanda X. Y. Chen, Thomas Cole, Jesse Armitage et autres
11 citationsNature Communications
Rewiring endogenous genes in CAR T cells for tumour-restricted payload delivery
Amanda X. Y. Chen, Kah Min Yap, Joelle S. Kim, Kevin Sek et autres
77 citationsNature
FOXO1 enhances CAR T cell stemness, metabolic fitness and efficacy
Jack D. Chan, C. Scheffler, Isabelle Munoz, Kevin Sek et autres
242 citationsNature
CRISPR-Cas9 screening identifies an IRF1-SOCS1-mediated negative feedback loop that limits CXCL9 expression and antitumor immunity
Imran G. House, Emily B. Derrick, Kevin Sek, Amanda X. Y. Chen et autres
5 citationsCell Reports
A2AR eGFP reporter mouse enables elucidation of A2AR expression dynamics during anti-tumor immune responses
Kirsten L. Todd, Junyun Lai, Kevin Sek, Yukuan Huang et autres
9 citationsNature Communications
CRISPR-Cas9 screening identifies an IRF1-SOCS1-mediated negative feedback loop that limits CXCL9 expression and antitumor immunity
Imran G. House, Emily B. Derrick, Kevin Sek, Amanda X. Y. Chen et autres
13 citationsCell Reports
MAIT cells regulate NK cell-mediated tumor immunity
Emma V. Petley, Hui‐Fern Koay, Melissa A. Henderson, Kevin Sek et autres
109 citationsNature Communications
CRISPR/Cas9 mediated deletion of the adenosine A2A receptor enhances CAR T cell efficacy
Lauren Giuffrida, Kevin Sek, Melissa A. Henderson, Junyun Lai et autres
223 citationsNature Communications
IL-15 Preconditioning Augments CAR T Cell Responses to Checkpoint Blockade for Improved Treatment of Solid Tumors
Lauren Giuffrida, Kevin Sek, Melissa A. Henderson, Imran G. House et autres
111 citationsMolecular Therapy
A New Safety Approach Allowing Reversible Control of CAR T Cell Responses
Amanda X. Y. Chen, Imran G. House, Paul A. Beavis, Phillip K. Darcy
1 citationMolecular Therapy
Adoptive cellular therapy with T cells expressing the dendritic cell growth factor Flt3L drives epitope spreading and antitumor immunity
Junyun Lai, Sherly Mardiana, Imran G. House, Kevin Sek et autres
222 citationsNature Immunology
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