Victor Facchinetti

Antileishmanial Evaluation and Mechanism of Action of Benzothiazole Derivatives with Aromatic/Heteroaromatic Hydrazone Moiety

Luciana Maria Ribeiro Antinarelli, Alessandra Campbell Pinheiro, Victor Facchinetti, T.R.A. Vasconcelos et autres

INTRODUCTION: Treatment of leishmaniasis is limited to a few drugs, with serious side effects and contraindications. Thus, the need for alternatives to treat this neglected infectious disease is undeniable. METHODS: In this work, a series of benzothiazole derivatives was synthesized, and their …

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Solvent-Assisted Catalysis: Water Promotes Ring Closure Formation of 2-Oxazolidinone from Amino Acid Derived N-Boc-Epoxide

Patrick de L. Barbosa, Victor Facchinetti, Cláudia R. B. Gomes, M.V.N. De Souza et autres

Oxazolidinones are important heterocyclic compounds with several therapeutic properties, especially antimicrobial activity, as seen in linezolid. Unexpectedly, a 2-oxazolidinone structurally similar to linezolid was obtained, prompting optimization of the reaction methodology and quantum calculations to rationalize the experimental observation. The reaction proceeded …

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Benzoxathiolone-Thiazolidinone Hybrids: A New Class in the Search for Anticancer Agents

Eliza de Lucas Chazin, Ligia S. da Silveira Pinto, Victor Facchinetti, Paula de Aquino Soeiro Portilho et autres

Background: Cancer continues to be a significant public health issue and one of the leading causes of death globally. In this context, developing new, potent, and more specific treatments against this disease is urgent. Methods: A total of 15 benzoxathiolone-thiazolidinones hybrids were …

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Mentol: Um Importante Produto Natural no Ensino de Química

Mariana Falcão Lopes Princisval Carlos, Victor Facchinetti, M.V.N. De Souza

Structural Metamorphosis: Rearranging Camphor-based Systems

Mariana Falcão Lopes Princisval Carlos, Cláudia R. B. Gomes, Victor Facchinetti, M.V.N. De Souza

Natural compounds are pivotal sources for synthesizing a vast array of biologically active substances in chemistry. Camphor is one of these substances, and both enantiomers are readily obtainable and play significant roles in various synthetic and therapeutic applications. This mini-review provides information …

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Ultrasound-assisted Synthesis of β-(N-arylamino)acrylates Derivatives, Key Intermediates of Biopotent Compounds

Gabriel de Oliveira Costa, Victor Facchinetti, Gabriel Oliveira Guimarães Fernandes, Alexandra Mitidieri Bastos Mol Pimentel et autres

β-(N-arylamino)acrylates are building blocks of great industrial interest as they allow the obtention of a variety of heterocyclic substances, such as quinoline and pyridone derivatives. Therefore, the development of new methodologies for the synthesis of these substances is still of interest. In …

OBTENÇÃO DE AMINAS PRIMÁRIAS A PARTIR DA REDUÇÃO DE NITROCOMPOSTOS AROMÁTICOS VIA PROTOCOLOS DE REAÇÕES SUSTENTÁVEIS PARTE II: EM MEIO ORGÂNICO

Lígia M. Costa Pinto, Victor Facchinetti, Breno Bernardes, Thamires M. da Costa et autres

SYNTHESIS OF PRIMARY AMINES FROM THE REDUCTION OF AROMATIC NITRO COMPOUNDS THROUGH SUSTAINABLE REACTION PROTOCOLS PART II: REACTIONS IN ORGANIC MEDIA. The reduction of nitroarenes is the main methodology to produce anilines, important precursors of building blocks, dyes, and drugs. Continuing our …

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Design, Synthesis, and Molecular Docking Studies of New Quinoline-Thiazole Hybrids, Potential Leads in the Development of Novel Antileukemic Agents

Victor Facchinetti, Cláudia R. B. Gomes, Karoline Chagas Lisboa Aboud, Rodolfo G. Fiorot et autres

This work describes the multigram-scale synthesis of the building-block N1 -(7-chloroquinolin4-yl)ethane-1,2-diamine via sonochemistry and its use in the synthesis of seven new quinoline-thiazole hybrids endowed with interesting anticancer activity. Target compounds were planned based on the drugs chloroquine and primaquine and the …

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Selênio, um elemento essencial à vida humana

Victor Facchinetti, Gabriel de Oliveira Costa, Letícia Bárbara Da Penha, Karoline Chagas Lisboa Aboud et autres

Introdução: o Selênio ao mesmo tempo em que é tóxico se ingerido em grandes quantidades, é, também, micronutriente essencial em diversos processos metabólicos de animais e humanos. A deficiência de selênio vem sendo relacionada à predispo-sição em desenvolver doenças como o câncer, …

Reposicionamento do fármaco baricitinibe para o tratamento da COVID-19

M.V.N. De Souza, Victor Facchinetti, Karoline Chagas Lisboa Aboud, Letícia Bárbara Da Penha et autres

Reposicionamento de fármacos é uma estratégia muito utilizada atualmente pela indústria farmacêutica. Essa estratégia é baseada no emprego de medicamentos disponíveis no mercado, que terão outras aplicações e serão utilizados no tratamento de outras doenças. A principal vantagem dessa abordagem, é o …

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OBTENÇÃO DE AMINAS PRIMÁRIAS A PARTIR DA REDUÇÃO DE NITROCOMPOSTOS AROMÁTICOS VIA PROTOCOLOS DE REAÇÕES SUSTENTÁVEIS EM MEIO AQUOSO

Breno Bernardes, Thamires M. da Costa, L.G.R.V. De Silva, Lígia A. Pinto et autres

SYNTHESIS OF PRIMARY AMINES FROM THE REDUCTION OF AROMATIC NITRO COMPOUNDS THROUGH SUSTAINABLE REACTION PROTOCOLS IN AQUEOUS MEDIUM. Aromatic amines are important intermediates in the industry to produce a wide array of products, and the reduction of aromatic nitro compounds is the …

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SYNTHESIS OF PRIMARY AMINES FROM THE REDUCTION OF AROMATIC NITRO COMPOUNDS THROUGH SUSTAINABLE REACTION PROTOCOLS IN AQUEOUS MEDIUM

Breno Bernardes, Thamires M. da Costa, Letícia de O. J. L. da Silva, Ligia S. da Silveira Pinto et autres

Aromatic amines are important intermediates in the industry to produce a wide array of products, and the reduction of aromatic nitro compounds is the main methodology for their preparation. Considering this fact, the objective of this review is to describe the development …