T.R.A. Vasconcelos

Evaluation in vitro and in silico of LIG08, a benzoxathiolone-thiazolidinone derivative, as a potential drug against Klebsiella pneumoniae

Felipe Pantoja Mesquita, Daiane Maria da Silva Brito, José Hélio de Araújo Filho, Raquel Carvalho Montenegro et autres

Abstract Infectious diseases represent one of the most critical and urgent global health challenges. However, the misuse of antibiotics has enhanced this issue, raising concerns about treatment effectiveness, particularly in the face of the emergence of antibiotic-resistant bacterial strains. In this context, …

br, id (code pays fourni par la source)

FLA94, an isatin derivative, inhibits Candida albicans growth by inducing membrane damage and ROS overaccumulation

Isabel Freitas, Pedro Filho Noronha Souza, José H. A. Filho, Daiane Maria da Silva Brito et autres

Background Infections caused by Candida albicans pose a significant clinical challenge worldwide due to their opportunistic nature and resistance to treatment.Research design and methods Here, compounds derived from isatin were evaluated for pharmacological and antifungal potential against C. albicans.Results Out of 19 …

br, ph (code pays fourni par la source)

Solvent-Assisted Catalysis: Water Promotes Ring Closure Formation of 2-Oxazolidinone from Amino Acid Derived N-Boc-Epoxide

Patrick de L. Barbosa, Victor Facchinetti, Cláudia R. B. Gomes, M.V.N. De Souza et autres

Oxazolidinones are important heterocyclic compounds with several therapeutic properties, especially antimicrobial activity, as seen in linezolid. Unexpectedly, a 2-oxazolidinone structurally similar to linezolid was obtained, prompting optimization of the reaction methodology and quantum calculations to rationalize the experimental observation. The reaction proceeded …

br, fr (code pays fourni par la source)

Benzoxathiolone-Thiazolidinone Hybrids: A New Class in the Search for Anticancer Agents

Eliza de Lucas Chazin, Ligia S. da Silveira Pinto, Victor Facchinetti, Paula de Aquino Soeiro Portilho et autres

Background: Cancer continues to be a significant public health issue and one of the leading causes of death globally. In this context, developing new, potent, and more specific treatments against this disease is urgent. Methods: A total of 15 benzoxathiolone-thiazolidinones hybrids were …

br (code pays fourni par la source)

OBTENÇÃO DE AMINAS PRIMÁRIAS A PARTIR DA REDUÇÃO DE NITROCOMPOSTOS AROMÁTICOS VIA PROTOCOLOS DE REAÇÕES SUSTENTÁVEIS PARTE II: EM MEIO ORGÂNICO

Lígia M. Costa Pinto, Victor Facchinetti, Breno Bernardes, Thamires da Costa et autres

SYNTHESIS OF PRIMARY AMINES FROM THE REDUCTION OF AROMATIC NITRO COMPOUNDS THROUGH SUSTAINABLE REACTION PROTOCOLS PART II: REACTIONS IN ORGANIC MEDIA. The reduction of nitroarenes is the main methodology to produce anilines, important precursors of building blocks, dyes, and drugs. Continuing our …

br (code pays fourni par la source)

Design, Synthesis, and Molecular Docking Studies of New Quinoline-Thiazole Hybrids, Potential Leads in the Development of Novel Antileukemic Agents

Victor Facchinetti, Cláudia R. B. Gomes, Karoline Chagas Lisboa Aboud, Rodolfo G. Fiorot et autres

This work describes the multigram-scale synthesis of the building-block N1 -(7-chloroquinolin4-yl)ethane-1,2-diamine via sonochemistry and its use in the synthesis of seven new quinoline-thiazole hybrids endowed with interesting anticancer activity. Target compounds were planned based on the drugs chloroquine and primaquine and the …

br (code pays fourni par la source)

Anticancer Activity and Molecular Targets of Piper cernuum Substances in Oral Squamous Cell Carcinoma Models

Thaíssa Queiróz Machado, Maria Emanuelle Damazio Lima, Rafael Carriello da Silva, Arthur Ladeira Macedo et autres

Oral squamous cell carcinoma (OSCC) is a worldwide public health problem, with high morbidity and mortality rates. The development of new drugs to treat OSCC is paramount. Piper plant species have shown many biological activities. In the present study, we show that …

br (code pays fourni par la source)

Marine Natural Products in the Battle against Dengue, Zika, and Chikungunya Arboviruses

Thayssa da Silva Ferreira Fagundes, T.R.A. Vasconcelos, Fernando Martins dos Santos, Bia Francis Rajsfus et autres

Arthropod-borne viruses (arboviruses) are a severe public health problem worldwide, consisting of a significant part of all the emerging infectious diseases. It is estimated that arboviruses infect hundreds of millions of people globally each year, resulting in several thousand deaths. Despite their …

us, br (code pays fourni par la source)

OBTENÇÃO DE AMINAS PRIMÁRIAS A PARTIR DA REDUÇÃO DE NITROCOMPOSTOS AROMÁTICOS VIA PROTOCOLOS DE REAÇÕES SUSTENTÁVEIS EM MEIO AQUOSO

Breno Bernardes, Thamires Costa, L.G.R.V. De Silva, Lígia A. Pinto et autres

SYNTHESIS OF PRIMARY AMINES FROM THE REDUCTION OF AROMATIC NITRO COMPOUNDS THROUGH SUSTAINABLE REACTION PROTOCOLS IN AQUEOUS MEDIUM. Aromatic amines are important intermediates in the industry to produce a wide array of products, and the reduction of aromatic nitro compounds is the …

br (code pays fourni par la source)

SYNTHESIS OF PRIMARY AMINES FROM THE REDUCTION OF AROMATIC NITRO COMPOUNDS THROUGH SUSTAINABLE REACTION PROTOCOLS IN AQUEOUS MEDIUM

Breno Bernardes, Thamires M. da Costa, Letícia de O. J. L. da Silva, Ligia S. da Silveira Pinto et autres

Aromatic amines are important intermediates in the industry to produce a wide array of products, and the reduction of aromatic nitro compounds is the main methodology for their preparation. Considering this fact, the objective of this review is to describe the development …

Synthesis and Biological Evaluation of Novel 1,3-Benzoxathiol-2-one Sulfonamides against Toxic Activities of the Venom of Bothrops jararaca and Bothrops jararacussu Snakes

Eliza de Lucas Chazin, Leonardo Martins, M.V.N. De Souza, Cláudia R. B. Gomes et autres

This work describes the synthesis of new 1,3-benzoxathiol-2-one sulfonamides and evaluation of their ability to inhibit some in vitro (coagulant, proteolytic and hemolytic) and in vivo (hemorrhagic, edematogenic and lethality) toxic activities of Bothrops jararaca and Bothrops jararacussu venoms. Compounds have been …

br (code pays fourni par la source)

Metabolomic fingerprinting of Brazilian marine sponges: a case study of Plakinidae species from Fernando de Noronha Archipelago

Thayssa da Silva Ferreira Fagundes, Larissa Ramos G. da Silva, Mateus de Freitas Brito, Letícia S.S. Schmitz et autres

br (code pays fourni par la source)