Yael Kalma

Artificial intelligence-driven trigger timing in planned oocyte cryopreservation: learning vs. nonlearning models

Roza Berkovitz Shperling, Dana Englander, Adiel Kahana, Yael Kalma et autres

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Predictive factors shaping fertility potential and reproductive outcomes in men with Klinefelter syndrome

Itai Atar, Shimi Barda, Yael Kalma, Sandra Edith Kleiman et autres

Klinefelter syndrome (KS), marked by testicular heterogeneity, provides a rationale for testicular sperm extraction in azoospermic men, yet large-scale evaluations of predictive and reproductive outcomes remain limited. This retrospective study included 79 karyotype-confirmed KS patients who underwent conventional testicular sperm extraction (cTESE) …

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Combining microTESE and trifocal TESE improves sperm retrieval and cryopreservation outcomes in nonobstructive azoospermia

Shimi Barda, Noga Fuchs Weizman, Ron Hauser, Haggar Zoë Aspitz et autres

PURPOSE: To evaluate whether combining microdissection testicular sperm extraction (microTESE) with trifocal testicular sperm extraction (TESE) in a single session improves sperm retrieval and cryopreservation outcomes in men with nonobstructive azoospermia. MATERIALS AND METHODS: Retrospective cohort study of 93 men with nonobstructive …

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Is intracytoplasmic sperm injection (ICSI) the solution when there is not any problem; exploring ICSI vs in vitro fertilization (IVF) outcomes in sibling oocytes from donor sperm assisted reproductive technology (ART) cycles

Ella Golbary Kinory, Yael Kalma, Shir Lavie, Shimi Barda et autres

CONTEXT: Intracytoplasmic sperm injection (ICSI) is increasingly used in assisted reproductive technology (ART), even in cases without male factor infertility. Its true benefit in such scenarios remains uncertain. AIMS: To determine whether ICSI provides any embryological or clinical advantage over conventional in …

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P-753 Novel Surgical Technique in Ovarian Tissue Transplantation Results in Successful IVF Pregnancies and deliveries : A Case Report of Post-Medulloblastoma Fertility Preservation

Foad Azem, Roza Berkovitz-Shperling, Yael Kalma, T Binyar et autres

Abstract Study question Can a novel surgical technique using motorized pipette filtration improve ovarian tissue transplantation outcomes in assisted reproduction? Summary answer The use of a motorized pipette system with precise filtration (0.45μm) in ovarian tissue transplantation led to successful IVF treatment. …

P-034 A rare treasure- factors shaping fertility potential and obstetrical outcomes in men with Klinefelter syndrome

İlyas Atar, S Dekalo, Yael Kalma, Sandra Edith Kleiman et autres

Abstract Study question What factors predict successful microsurgical sperm extraction in azoospermic Klinefelter Syndrome (KS) patients, and what are their chances of achieving parenthood? Summary answer Age, follicle-stimulating hormone and testosterone influence the sperm-retrieval rate (SRR). Once retrieved, sperm achieved pregnancy and …

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Stringent Regulations of Oocyte Donation Among Jewish Women in Israel: Characteristics and Outcomes of the National Oocyte Donation Program in One Central IVF Unit

Livia Preisler, Nivin Samara, Yael Kalma, Tal Arad et autres

On September 5, 2010, the Israeli Parliament passed a law that allows Israeli female residents to donate their oocytes to infertile Israeli female residents. This law includes unique restrictions that do not exist in other countries. Our aim was to characterize Israeli …

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BlastAssist: a deep learning pipeline to measure interpretable features of human embryos

Helen Y Yang, Brian Leahy, Won-Dong Jang, Donglai Wei et autres

STUDY QUESTION: Can the BlastAssist deep learning pipeline perform comparably to or outperform human experts and embryologists at measuring interpretable, clinically relevant features of human embryos in IVF? SUMMARY ANSWER: The BlastAssist pipeline can measure a comprehensive set of interpretable features of …

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A clinical predictive model for live birth in women of advanced age undergoing PGT cycles

Or Bercovich, Galia Klar, Talya Shaulov, Benny Almog et autres

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Isoform-resolved transcriptome of the human preimplantation embryo

Denis Torre, Nancy J. Francoeur, Yael Kalma, Betsaida Salom Melo et autres

Human preimplantation development involves extensive remodeling of RNA expression and splicing. However, its transcriptome has been compiled using short-read sequencing data, which fails to capture most full-length mRNAs. Here, we generate an isoform-resolved transcriptome of early human development by performing long- and …

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P-699 A clinical predictive model for live birth in women of advanced age undergoing PGT cycles

Or Bercovich, Gregory Klar, Talya Shaulov, Benny Almog et autres

Abstract Study question In 37–45-year-old women undergoing preimplantation genetic testing, who will benefit from repeated cycles until birth? Summary answer The chance of delivering after repeated cycles is higher in those with at least one top-quality unaffected embryo in their first preimplantation …

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A pathogenic variant in the uncharacterized RNF212B gene results in severe aneuploidy male infertility and repeated IVF failure

Moran Gershoni, Tslil Braun, Ron Hauser, Shimi Barda et autres

Quantitative and qualitative spermatogenic impairments are major causes of men’s infertility. Although in vitro fertilization (IVF) is effective, some couples persistently fail to conceive. To identify causal variants in patients with severe male infertility factor and repeated IVF failures, we sequenced the …

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