Jake Cornwall-Scoones

Solid-like PAR protein assemblies encode long-term spatial memory of cell polarity during suspended animation

Joana Borrego-Pinto, Jake Cornwall-Scoones, Nisha Hirani, KangBo Ng et autres

Abstract During suspended animation, organisms must preserve cellular organization despite the collapse of the active biochemical processes that normally maintain it. Here we show that anoxia-induced suspended animation drives cell polarity proteins into a poised, memory-like state that preserves spatial information and …

gb, us (code pays fourni par la source)

Combinatorial BMP4 and activin direct the choice between alternate routes to endoderm in a stem cell model of human gastrulation

Oliver C K Inge, Elias Copin, Jake Cornwall-Scoones, Borzo Gharibi et autres

Lineage specification requires accurate interpretation of multiple signaling cues. However, how combinatorial signaling histories influence fate outcomes remains unclear. We combined single-cell transcriptomics, live-cell imaging, and mathematical modeling to explore how activin and bone morphogenetic protein 4 (BMP4) guide fate specification during …

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Mechanochemical coupling of cell shape and organ function optimizes heart size and contractile efficiency in zebrafish

Toby G. R. Andrews, Jake Cornwall-Scoones, Marie‐Christine Ramel, Kirti Gupta et autres

How simple tissue primordia sculpt complex functional organs, robustly and reproducibly, remains elusive. During zebrafish development, the embryonic myocardial wall matures into an intricate 3D architecture, composed of an outer compact layer enveloping an inner layer of multicellular trabecular ridges. How these …

gb (code pays fourni par la source)

The cis-regulatory logic integrating spatial and temporal patterning in the vertebrate neural tube

Isabel Zhang, Giulia L. M. Boezio, Jake Cornwall-Scoones, Thomas J.R. Frith et autres

The vertebrate neural tube generates a large diversity of molecularly and functionally distinct neurons and glia from a small progenitor pool. While the role of spatial patterning in organizing cell fate specification has been extensively studied, temporal patterning, which controls the timing …

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Predictable Engineering of Signal-Dependent Cis-Regulatory Elements

Jake Cornwall-Scoones, Dirk Benzinger, T Yu, Alberto Pezzotta et autres

Abstract Cis-regulatory elements (CREs) control how genes respond to external signals, but the principles governing their structure and function remain poorly understood. While differential transcription factor binding is known to regulate gene expression, how CREs integrate the amount and combination of inputs …

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Timely TGFβ signalling inhibition induces notochord

Tiago Rito, Ashley R.G. Libby, Madeleine Demuth, Marie‐Charlotte Domart et autres

Abstract The formation of the vertebrate body involves the coordinated production of trunk tissues from progenitors located in the posterior of the embryo. Although in vitro models using pluripotent stem cells replicate aspects of this process 1–10 , they lack crucial components, …

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No Country for Old Frameworks? Vertex Models and Their Ongoing Reinvention to Study Tissue Dynamics

Natalia Briñas-Pascual, Jake Cornwall-Scoones, D. P. O’Hanlon, Pilar Guerrero et autres

Vertex models have become essential tools for understanding tissue morphogenesis by simulating the mechanical and geometric properties of cells in various biological systems. These models represent cells as polygons or polyhedra, capturing cellular interactions such as adhesion, tension, and force generation. This …

es, gb (code pays fourni par la source)

Multiscale mechanics drive functional maturation of the vertebrate heart

Toby G. R. Andrews, Jake Cornwall-Scoones, Marie‐Christine Ramel, Kirti Gupta et autres

Abstract How simple tissue primordia sculpt complex functional organs, robustly and reproducibly, remains elusive. As the zebrafish embryo grows into a larva, to improve its heart function, the embryonic myocardial wall transforms into an intricate 3D architecture, composed of an outer compact …

gb (code pays fourni par la source)

Patterning and folding of intestinal villi by active mesenchymal dewetting

Tyler R. Huycke, Teemu J. Häkkinen, Hikaru Miyazaki, Vasudha Srivastava et autres

Tissue folds are structural motifs critical to organ function. In the intestine, bending of a flat epithelium into a periodic pattern of folds gives rise to villi, finger-like protrusions that enable nutrient absorption. However, the molecular and mechanical processes driving villus morphogenesis …

us (code pays fourni par la source)

The cis-regulatory logic integrating spatial and temporal patterning in the vertebrate neural tube

Isabel Zhang, Giulia L. M. Boezio, Jake Cornwall-Scoones, Thomas J.R. Frith et autres

Abstract The vertebrate neural tube generates a large diversity of molecularly and functionally distinct neurons and glia from a small progenitor pool. While the role of spatial patterning in organising cell fate specification has been extensively studied, temporal patterning, which controls the …

gb, de (code pays fourni par la source)

Multiscale Mechanics Drive Functional Maturation of the Vertebrate Heart

Toby G. R. Andrews, Jake Cornwall-Scoones, Marie‐Christine Ramel, Kirti Gupta et autres

gb (code pays fourni par la source)

Patterning and folding of intestinal villi by active mesenchymal dewetting

Tyler R. Huycke, Hikaru Miyazaki, Teemu J. Häkkinen, Vasudha Srivastava et autres

ABSTRACT Tissue folding generates structural motifs critical to organ function. In the intestine, bending of a flat epithelium into a periodic pattern of folds gives rise to villi, the numerous finger-like protrusions that are essential for nutrient absorption. However, the molecular and …

us (code pays fourni par la source)