Accès ouvert
2024
article
OpenAlex
Tyler R. Huycke, Teemu J. Häkkinen, Hikaru Miyazaki, Vasudha Srivastava et autres
Tissue folds are structural motifs critical to organ function. In the intestine, bending of a flat epithelium into a periodic pattern of folds gives rise to villi, finger-like protrusions that enable nutrient absorption. However, the molecular and mechanical processes driving villus morphogenesis …
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Accès ouvert
2023
preprint
OpenAlex
Tyler R. Huycke, Hikaru Miyazaki, Teemu J. Häkkinen, Vasudha Srivastava et autres
ABSTRACT Tissue folding generates structural motifs critical to organ function. In the intestine, bending of a flat epithelium into a periodic pattern of folds gives rise to villi, the numerous finger-like protrusions that are essential for nutrient absorption. However, the molecular and …
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Accès ouvert
2021
article
OpenAlex
Wen Li Kelly Chen, Emily C. Suter, Hikaru Miyazaki, Jason G. Velazquez et autres
Intestinal homeostasis is tightly regulated by the orchestrated actions of a multitude of cell types, including enterocytes, goblet cells, and immune cells. Disruption of intestinal barrier function can increase susceptibility to pathogen invasion and destabilize commensal microbial-epithelial-immune interaction, manifesting in various intestinal …
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Accès ouvert
2017
article
OpenAlex
Alex J. Hughes, Hikaru Miyazaki, Maxwell C. Coyle, Jesse Zhang et autres
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Accès ouvert
2017
article
OpenAlex
Irene Bosch, Helena de Puig, Megan Hiley, Marc Carré-Camps et autres
The recent Zika virus (ZIKV) outbreak demonstrates that cost-effective clinical diagnostics are urgently needed to detect and distinguish viral infections to improve patient care. Unlike dengue virus (DENV), ZIKV infections during pregnancy correlate with severe birth defects, including microcephaly and neurological disorders. …
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Accès ouvert
2017
preprint
OpenAlex
Alex J. Hughes, Hikaru Miyazaki, Maxwell C. Coyle, Jesse Zhang et autres
SUMMARY Many tissues fold during development into complex shapes. Engineering this process in vitro would represent an important advance for tissue engineering. We use embryonic tissue explants, finite element modeling, and 3D cell patterning techniques to show that a mechanical compaction of …
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