Mingchuan Mao

Comprehensive metabolic programming by enzymatic nanovesicle for acute kidney injury therapy

Yao Lei, Yuzhu Wu, Chao Li, Canwei Zou et autres

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Challenges and Emerging Strategies of Immunotherapy for Glioblastoma

Mingchuan Mao, Lei Yao, Xianbin Ma

Glioblastoma (GBM) is recognized as the most lethal primary malignant tumor of the central nervous system. Although traditional treatments can somewhat prolong patient survival, the overall prognosis remains grim. Immunotherapy has become an effective method for GBM treatment. Oncolytic virus, checkpoint inhibitors, …

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AND-Gate Logic Förster Resonance Energy Transfer/Magnetic Resonance Tuning Nanoprobe for Programmable Antitumor Immunity Imaging

Xianbin Ma, Mingchuan Mao, Zhenya Liu, Chao Lun Liang et autres

Simultaneous detection of different biomarkers related to the spatiotemporally dynamic immune events is of particular importance for the accurate evaluation of antitumor immune effects. Here, we have developed an AND-gate logic dual resonance energy transfer nanoprobe (named DRET) for dynamic monitoring of …

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Monitoring the Cascade of Tumor‐specific Immune Response in vivo via Chemoenzymatic Proximity Labeling

Chao Lun Liang, Jiaqi He, Xin Zhao, Jie Hong et autres

Monitoring the highly dynamic and complex immune response remains a great challenge owing to the lack of reliable and specific approaches. Here, we develop a strategy to monitor the cascade of tumor immune response through the cooperation of pore-forming alginate gel with …

cn (code pays fourni par la source)

Monitoring the Cascade of Tumor‐specific Immune Response in vivo via Chemoenzymatic Proximity Labeling

Chao Lun Liang, Jiaqi He, Xin Zhao, Jie Hong et autres

Abstract Monitoring the highly dynamic and complex immune response remains a great challenge owing to the lack of reliable and specific approaches. Here, we develop a strategy to monitor the cascade of tumor immune response through the cooperation of pore‐forming alginate gel …

cn (code pays fourni par la source)

Nanoprobe-based molecular imaging for tumor stratification

Xianbin Ma, Mingchuan Mao, Jiaqi He, Chao Liang et autres

The responses of patients to tumor therapies vary due to tumor heterogeneity. Tumor stratification has been attracting increasing attention for accurately distinguishing between responders to treatment and non-responders. Nanoprobes with unique physical and chemical properties have great potential for patient stratification. This …

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Viral Protein‐Pseudotyped and siRNA‐Electroporated Extracellular Vesicles for Cancer Immunotherapy

Houli Liu, Lili Huang, Mingchuan Mao, Jingjing Ding et autres

Abstract Extracellular vesicles (EVs) have shown great potential in drug delivery, disease diagnosis, and treatment owing to their versatile native features and functions. RNA interference (RNAi) therapeutics that block the programmed death‐1 (PD‐1) and programmed death‐ligand 1 (PD‐L1) pathway have attracted increasing …

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