Xianbin Ma

Ultrasmall Ag₂Se@Mn quantum dots enable dual-modal imaging-guided early detection and antioxidant therapy of acute kidney injury

Yun Qu, Yiping Gu, Qinzhi Zeng, Xianbin Ma et autres

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Renal-clearable probes for in vivo imaging of acute kidney injury

Yun Qu, Xianbin Ma, Hai-Yan Xie

The design principles of renal-clearable probes are systematically elucidated, showing how key physicochemical parameters can be tuned to optimize renal filtration and clearance.

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Potentiating immunotherapy in “immune-cold” solid tumors through orchestrating T cell immunity via tumor-specific genetic engineering

Jiaqi He, Chunguang Zhang, Chao Liang, Yongheng Li et autres

T cells and driving sustained immunity. Concurrently, αCD3-mediated T cell redirection not only amplifies TCR signaling but also reverses exhausted T cells. The orchestrated T cell immunity significantly potentiates checkpoint inhibitor and chimeric antigen receptor (CAR)-T cell therapies in "immune-cold" tumors without …

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Achieving Near‐Infrared Organic Room‐Temperature Phosphorescence for High‐Resolution Immune Response Monitoring and Bioimaging

Yeyun Zhao, Xianbin Ma, Shisheng Cui, Jiamin Qu et autres

Organic near-infrared (NIR) room-temperature phosphorescent (RTP) materials hold great potential for bioimaging due to their ability to eliminate background noise and tissue autofluorescence. Here, we synthesized octa-ring fused RTP molecules (TPP-BN and TPP-BF) with B─N coordination bonds via a two-step reaction, enabling …

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Achieving Near‐Infrared Organic Room‐Temperature Phosphorescence for High‐Resolution Immune Response Monitoring and Bioimaging

Yeyun Zhao, Xianbin Ma, Shisheng Cui, Jiamin Qu et autres

Abstract Organic near‐infrared (NIR) room‐temperature phosphorescent (RTP) materials hold great potential for bioimaging due to their ability to eliminate background noise and tissue autofluorescence. Here, we synthesized octa‐ring fused RTP molecules (TPP‐BN and TPP‐BF) with B─N coordination bonds via a two‐step reaction, …

cn (code pays fourni par la source)

Intratumoral antigen-presenting cell activation by a nanovesicle for the concurrent tertiary lymphoid structure de novo neogenesis

Sucheng Li, Xianbin Ma, Wan‐Ru Zhuang, Lei Yao et autres

Tertiary lymphoid structures (TLSs) usually lead to significantly improved clinical benefits in immunotherapy but are rarely observed within native tumors. The current approaches are difficult in effectively inducing TLS formation, let alone fully exploiting its anticancer efficacy. Here, a biomimetic nanovesicle (ADU-S@M1) …

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Challenges and Emerging Strategies of Immunotherapy for Glioblastoma

Mingchuan Mao, Lei Yao, Xianbin Ma

Glioblastoma (GBM) is recognized as the most lethal primary malignant tumor of the central nervous system. Although traditional treatments can somewhat prolong patient survival, the overall prognosis remains grim. Immunotherapy has become an effective method for GBM treatment. Oncolytic virus, checkpoint inhibitors, …

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Correction: A bottlebrush-architectured dextran polyprodrug as an acidity-responsive vector for enhanced chemotherapy efficiency

Tian Zhang, Yajun Wang, Xianbin Ma, Cuilan Hou et autres

Correction for ‘A bottlebrush-architectured dextran polyprodrug as an acidity-responsive vector for enhanced chemotherapy efficiency’ by Tian Zhang, et al. , Biomater. Sci. , 2020, 8 , 473–484, https://doi.org/10.1039/C9BM01692A.

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AND-Gate Logic Förster Resonance Energy Transfer/Magnetic Resonance Tuning Nanoprobe for Programmable Antitumor Immunity Imaging

Xianbin Ma, Mingchuan Mao, Zhenya Liu, Chao Liang et autres

Simultaneous detection of different biomarkers related to the spatiotemporally dynamic immune events is of particular importance for the accurate evaluation of antitumor immune effects. Here, we have developed an AND-gate logic dual resonance energy transfer nanoprobe (named DRET) for dynamic monitoring of …

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Chemistry-Enabled Intercellular Enzymatic Labeling for Monitoring the Immune Effects of Cytotoxic T Lymphocytes In Vivo

Jiaqi He, Chao Liang, Xin‐He Yu, Xianbin Ma et autres

Abstract Monitoring the effector function of cytotoxic T lymphocytes (CTLs) in vivo remains a great challenge. Here, we develop a chemistry-enabled enzymatic labeling approach to evaluate the tumor-specific immune response of CTLs by precisely monitoring the interaction between CTLs and tumor cells. …

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Monitoring the Cascade of Tumor‐specific Immune Response in vivo via Chemoenzymatic Proximity Labeling

Chao Liang, Jiaqi He, Xin Zhao, Jie Hong et autres

Monitoring the highly dynamic and complex immune response remains a great challenge owing to the lack of reliable and specific approaches. Here, we develop a strategy to monitor the cascade of tumor immune response through the cooperation of pore-forming alginate gel with …

cn (code pays fourni par la source)

Monitoring the Cascade of Tumor‐specific Immune Response in vivo via Chemoenzymatic Proximity Labeling

Chao Liang, Jiaqi He, Xin Zhao, Jie Hong et autres

Abstract Monitoring the highly dynamic and complex immune response remains a great challenge owing to the lack of reliable and specific approaches. Here, we develop a strategy to monitor the cascade of tumor immune response through the cooperation of pore‐forming alginate gel …

cn (code pays fourni par la source)