Guobiao Yang

Spontaneous rupture of hepatic metastasis as the initial presentation of gastric hepatoid adenocarcinoma: a rare case report and literature review

Bin Zhou, Yingchao Lu, Juan Zhang, Guobiao Yang et autres

Hepatoid adenocarcinoma (HAC) is an extremely rare and highly malignant tumor with histological features resembling hepatocellular carcinoma but originating from extrahepatic organs, most commonly in the stomach, known as gastric hepatoid adenocarcinoma (GHA). Spontaneous rupture of hepatic metastasis as the initial presentation …

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Regulating the expression of exercise-induced micro-RNAs and long non-coding RNAs: implications for controlling cardiovascular diseases and heart failure

Guobiao Yang, Wanying Yang

The intricate interplay between physical training and non-coding RNAs, specifically microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), has attracted considerable attention in understanding physiological adaptations and pathological conditions. Both miRNAs and lncRNAs are essential modulators of gene expression, influencing various cellular processes, …

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Therapeutic and Prognostic Potential of G Protein‐Coupled Receptors in Lung Adenocarcinoma: Evidence From Transcriptome Data and In Vitro Experiments

Feiyan Yang, Jianye Yang, Guobiao Yang

BACKGROUND: G protein-coupled receptors (GPCRs), the largest family of cell-surface molecules involve in various signal transduction, have recently been recognized as important drivers of cancer. However, few studies have reported on the potential of GPCRs as therapeutic targets or biomarkers in lung …

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Worenine enhances the sensitivity of non-small cell lung cancer A549/DDP cells to cisplatin via HIF-1α/BNIP3-mediated mitophagy

Guobiao Yang, Ming Tong Xu, Mingliang Wu, Ya Zhang et autres

Mitophagy has been implicated in chemoresistance in various cancers. Worenine, an active compound derived from Coptidis rhizome, has exhibited anti-tumor activity. We aimed to clarify the impacts of worenine on regulating the cisplatin (DDP) sensitivity and mitophagy in DDP-resistant non-small cell lung …

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Innovative Design of Automobile Wheel Rim Based on Honeycomb Features

Zhaohua Wang, Chaoshi Wang, Guobiao Yang, Fenghe Wu

Lightweight is one of the primary design goals for the innovative development of wheel hubs. A new type of automobile wheel rim is proposed in this paper. The wheel rim is divided into wheel rim face and rib. The thickness of the …

The amino acid and carnitine concentration changes in bronchoalveolar lavage fluid from lung cancer patients

Xiaojun Sun, Mengmin Xu, Liren Ding, Guobiao Yang et autres

OBJECTIVE: To screen out potential biomarkers by analyzing fundamental nutrients in the bronchoalveolar lavage fluid (BALF) before confirming the lung cancer. METHODS: In this study, 44 patients were enrolled with clinical information. The concentrations of 23 amino acids and 35 carnitines in …

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An Intelligence Sports Training of Improving Poor College Student Self-Efficacy: Simulation, Experiment and Analysis

Baotong Jia, Chunmei Zhao, Guobiao Yang

The physical and mental health of impoverished college students has always been the focus of poverty alleviation work. In order to improve the sense of self-efficacy of poor college students, this paper innovatively puts forward an intelligent training method, the effectiveness of …

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GUX-Analyzer: A Deep Multi-modal Analyzer Via Motivational Flow For Game User Experience

Zhitao Liu, Ning Xie, Guobiao Yang, Jiale Dou et autres

Quantitative analysis of Game User eXperience (GUX) is important to the game industry. Different from the typical questionnaire analysis, this paper focuses on the computational analysis of GUX. We aim to analyze the relationship between game and players using the multi-modal data …

Fast-PPO: Proximal Policy Optimization with Optimal Baseline Method

Zhu Qiang Xiao, Ning Xie, Guobiao Yang, Zhenjiang Du

Deep deterministic policy gradient (DDPG) is a useful deep reinforcement learning approach, but it tends to suffer from instability of gradient estimates. Recent methods such as PPO just limit the policy update under lower speed to keep stability by chance. In this …

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Heparin coated meta-organic framework co-delivering doxorubicin and quercetin for effective chemotherapy of lung carcinoma

Xiaojun Sun, Yongxing Li, Liang Zhong Xu, Xinyu Shi et autres

Objective To develop and evaluate a drug delivery system (DDS) capable of targeting cancer cells while at the same time delivering two chemotherapeutic agents to overcome multidrug resistance (MDR). Methods This study developed a DDS composed of heparin (HA)-coated meta-organic framework (MOF) …

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Investigation of the Thermal Loading and Random Vibration Influences on Fatigue Life of the Solder Joints for a Metal-Oxide-Semiconductor-Field-Effect Transistor in a DC-DC Power Boost Converter

Songgang Li, Umashankar Subramaniam, Guobiao Yang, Davood Ghaderi et autres

This study presents the effects of the vibration and thermal cycling on the fatigue life of a power Metal Oxide Semiconductor Field Effect Transistor (MOSFET) in a power converter circuit. The fatigue mechanism in per loading mode was investigated separately and based …

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Experimental Measurement of Metal Strength and Stiffness Using a Double-Side 3D Digital Image Correlation Setup

Bernard Sia, Guobiao Yang, Junrui Li, Liangxiang Yang