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In this issue, Keegan et al. (https://doi.org/10.1083/jcb.202512053) uncover molecular dynamics of biphasic centromere histone assembly in the Drosophila male germline: initially mitotic-like, then chaperone independent. These findings highlight germline-specific adaptations in centromere assembly that deviate from the somatic cell paradigm.
us (code pays fourni par la source)
Anna Maria McKane, Isha Vijay Chauhan, Donald Miller, Sharmila Ghosh et autres
us (code pays fourni par la source)
Catherine A. Tower, Gabriel L. Manske, Emily Lenk Ferrell, Dilara N. Anbarci et autres
Across metazoan species, the centromere-specific histone variant CENP-A is essential for accurate chromosome segregation, yet its regulation during the mammalian parental-to-zygote transition is poorly understood. To address this, we generated a CENP-A-mScarlet mouse model that revealed sex-specific dynamics: mature sperm retain 10% …
us, Égypte, de (code pays fourni par la source)
Catherine A. Tower, Gabriel L. Manske, Emily Lenk Ferrell, Dilara N. Anbarci et autres
Summary Across metazoan species, the centromere-specific histone variant CENP-A is essential for accurate chromosome segregation, yet its regulation at the parental-to-zygote transition in mammals is poorly understood. To address this, we developed a CENP-A-mScarlet knock-in mouse model, which revealed sex-specific dynamics: mature …
us, Égypte, gb, de (code pays fourni par la source)
Jay N. Joshi, Neha Changela, Lia Mahal, Janet Ko Jang et autres
The reductional division of meiosis I requires the separation of chromosome pairs towards opposite poles. We have previously implicated the outer kinetochore protein SPC105R/KNL1 in driving meiosis I chromosome segregation through lateral attachments to microtubules and coorientation of sister centromeres. To identify …
us (code pays fourni par la source)
Jay N. Joshi, Neha Changela, Lia Mahal, Tyler Defosse et autres
Abstract The reductional division of meiosis I requires the separation of chromosome pairs towards opposite poles. We have previously implicated the outer kinetochore protein SPC105R/KNL1 in driving meiosis I chromosome segregation through lateral attachments to microtubules and co-orientation of sister centromeres. To …
nl, us (code pays fourni par la source)
Arunika Das, Katelyn G. Boese, Kiku-e K. Tachibana, Sung Hee Baek et autres
us, de, kr (code pays fourni par la source)
Arunika Das, Katelyn G. Boese, Kiku-e K. Tachibana, Sung Hee Baek et autres
SUMMARY Centromeres direct genetic inheritance but are not themselves genetically encoded. Instead, centromeres are defined epigenetically by the presence of a histone H3 variant, CENP-A 1 . In cultured somatic cells, an established paradigm of cell cycle-coupled propagation maintains centromere identity: CENP-A …
us, de, kr, gb (code pays fourni par la source)
Ajitesh Reddy, Arunika Das, Yudhishthir Raut, Pulkit Tiwari
Now a days, with the rising demand for vehicles, the rate of accidents is also increasing. Speedy roads like expressways where people avoid the idea to stop and help the victim. Victims of accidents happening on isolated roads also die due to …
in (code pays fourni par la source)
Arunika Das, Katelyn G. Boese, Kiku-e K. Tachibana, Sung Hee Baek et autres
us, de, kr, gb (code pays fourni par la source)
The post-reproductive phase or menopause in females is triggered by a physiological timer that depends on a threshold of follicle number in the ovary. Curiously, reproductive senescence appears to be decoupled from chronological age and is instead thought to be a function …
us, gr (code pays fourni par la source)
Gabriel L. Manske, Kelsey C. Jorgensen, Bin Ma, Mansour Aboelenain et autres
Summary The CENP-A histone variant epigenetically defines centromeres, where its levels and locations are precisely maintained through mitotic cell divisions. However, differences in centromere CENP-A propagation in soma versus female/male germline remains poorly understood. Here, we generated C enpa mScarlet mice and …
us, Égypte (code pays fourni par la source)
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