Piotr M. Skowron

Cpne7 Peptides Enhance the Osteogenic Potential of Adipose Tissue-Derived Mesenchymal Stem Cells

Agata Tymińska, Aneta Skoniecka, Natalia Karska, Katarzyna Czerwiec et autres

Cartilage and osteochondral disorders pose an increasing clinical, economic, and social challenge. With an aging population, there is a need to develop innovative, nonsurgical strategies for treating defects, fractures, and other osteochondral disorders. Bone implants require surgical intervention, carry a risk of …

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Alginate formulations with high loads of zebularine and retinoic acid promote tissue growth and innervation and induce extensive epigenetic repatterning

Paulina Słonimska, Jakub Baczyński-Keller, Rafał Płatek, Milena Deptuła et autres

The study presents the development of a small-molecule epigenetic regenerative therapy that combines a demethylating agent, zebularine, with retinoic acid, acting as a transcriptional activator, and an alginate carrier. Subcutaneously injected formulations based on 2% sodium alginate containing high loads of zebularine …

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Development of PDGF-BB-derived biomaterial: An ‘artificial’ concatemeric protein for regenerative applications

Milena Deptuła, Joanna Żebrowska, Agata Tymińska, Katarzyna Czerwiec et autres

Wound healing complications affect millions of people each year. New methods are constantly being pursued since the existing ones are not entirely effective. Our previous research on platelet-derived growth factor (PDGF-BB)-derived peptides demonstrated that one of them, PDGF2, possesses promising pro-regenerative potential. …

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The first thermophilic phage display system

Piotr M. Skowron, Ireneusz Sobolewski, Katarzyna Adamowicz, Joanna Morcinek-Orłowska et autres

Phage display technology is a powerful technique that allows to expose any peptide fused to a bacteriophage coat protein on the surface of the virion. However, the phage display systems have limitations that impair their applications in microbiology and biotechnology. We present …

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Mechanical Thrombectomy Access in Africa: A Mission Thrombectomy Study Subanalysis

Gabriela Alejo, Sidarrth Prasad, Fadar Oliver Otite, Erica Jones et autres

troke burden and mortality may be higher in Africa compared with other world regions.1 The large vessel occlusion stroke subtype portends the highest mortality risk but mechanical thrombectomy (MT) can mitigate this. MT utilization is nearly 500-fold lower in low-/middle-income countries compared …

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Identifying differentiation markers between dermal fibroblasts and adipose-derived mesenchymal stromal cells (AD-MSCs) in human visceral and subcutaneous tissues using single-cell transcriptomics

Magdalena Koczkowska, Anna Kostecka, Małgorzata Zawrzykraj, Kamil Myszczyński et autres

BACKGROUND: Adipose-derived mesenchymal stromal cells (AD-MSCs) and fibroblasts are both widely used in regenerative medicine, demonstrating significant potential for personalized cell therapy. A major challenge in their use lies in their high biological similarity, encompassing morphology, differentiation capabilities, and flow cytometric markers, …

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Evaluation of WHO Measles Eradication Programme for the European Region of 53 Countries with Emphasis on Poland in the Years 2003–2014

Dominika Mucha, Beata Łubkowska, Joanna Jeżewska-Frąckowiak, Piotr M. Skowron

BACKGROUND: The vaccination programmes after the 2nd World War and the application of safe and effective vaccines were expected to eliminate infectious diseases within the World Health Organization (WHO) European Region. However, epidemiological indexes show isolated cases and local epidemiology outbreaks of …

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New-Generation Antibacterial Agent—Cellulose-Binding Thermostable TP84_Endolysin

Małgorzata Ponikowska, Joanna Żebrowska, Piotr M. Skowron

The increasing antibiotic resistance among bacteria challenges the biotech industry to search for new antibacterial molecules. Endolysin TP84_28 is a thermostable, lytic enzyme, encoded by the bacteriophage (phage) TP-84, and it effectively digests host bacteria cell wall. Biofilms, together with antibiotic resistance, …

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A novel chitosan-peptide system for cartilage tissue engineering with adipose-derived stromal cells

Agata Tymińska, Natalia Karska, Aneta Skoniecka, Małgorzata Zawrzykraj et autres

The natural healing process of cartilage injuries often fails to fully restore the tissue’s biological and mechanical functions. Cartilage grafts are costly and require surgical intervention, often associated with complications such as intraoperative infection and rejection by the recipient due to ischemia. …

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New-Generation Antibacterial Agent – Cellulose-Binding Thermostable TP-84 Fusion Endolysin

Małgorzata Ponikowska, Joanna Żebrowska, Piotr M. Skowron

The increasing antibiotic resistance among bacteria challenges the biotech industry to search for new antibacterial molecules. Endolysin TP84_28 is a thermostable, lytic enzyme, encoded by the bacteriophage TP-84, and it effectively digests host bacteria cell wall. Biofilms, together with antibiotic resistance, are …

Development of a small-molecule epigenetic regenerative therapy. Subcutaneous administration of alginate formulations with high loads of zebularine and retinoic acid promotes tissue growth, vascularization and innervation and induces extensive epigenetic repatterning

Paulina Słonimska, Jakub Baczyński-Keller, Rafał Płatek, Milena Deptuła et autres

Abstract Recently, zebularine, a small-molecule epigenetic inhibitor and retinoic acid, acting as a transcriptional activator, have been found to induce tissue regeneration. In this study, the pro-regenerative properties of zebularine and retinoic acid were combined with the potential of the alginate carrier …

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Substrate specificity profiling of heat-sensitive serine protease from the fungus Onygena corvina

Paulina Kasperkiewicz, Sonia Kołt, Tomasz Janiszewski, Piotr M. Skowron et autres

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