Rafał Płatek

Insights into small-molecule neurotransmitter levels and distribution during tissue regeneration in an ear pinna model in mice

Anfisa Ronda, Rafał Płatek, Paulina Słonimska, Katarzyna Kozłowska-Tylingo et autres

Best known for their functions in the nervous system, neurotransmitters also play prominent roles in wound healing. The study analysed the spatiotemporal expression of acetylcholine, dopamine, gamma-aminobutyric acid, serotonin, and its metabolite, 5-hydroxyindoleacetic acid, in regenerating mouse ear pinna during normal healing …

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Body weight as a confounder inversely correlating with wound closure. A retrospective analysis of observations in normal-weight mice

Paulina Słonimska, Jakub Baczyński-Keller, Piotr Sass, Paweł Sosnowski et autres

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Alginate formulations with high loads of zebularine and retinoic acid promote tissue growth and innervation and induce extensive epigenetic repatterning

Paulina Słonimska, Jakub Baczyński-Keller, Rafał Płatek, Milena Deptuła et autres

The study presents the development of a small-molecule epigenetic regenerative therapy that combines a demethylating agent, zebularine, with retinoic acid, acting as a transcriptional activator, and an alginate carrier. Subcutaneously injected formulations based on 2% sodium alginate containing high loads of zebularine …

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Development of a small-molecule epigenetic regenerative therapy. Subcutaneous administration of alginate formulations with high loads of zebularine and retinoic acid promotes tissue growth, vascularization and innervation and induces extensive epigenetic repatterning

Paulina Słonimska, Jakub Baczyński-Keller, Rafał Płatek, Milena Deptuła et autres

Abstract Recently, zebularine, a small-molecule epigenetic inhibitor and retinoic acid, acting as a transcriptional activator, have been found to induce tissue regeneration. In this study, the pro-regenerative properties of zebularine and retinoic acid were combined with the potential of the alginate carrier …

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Microscopic Imaging to Visualize the Distribution of Dietary Nucleic Acids in Food Products of Various Origins

Anna Kościelak, Zuzanna Koziara, Ana Pons Maria, Rafał Płatek et autres

Dietary nucleic acids (dietNAs) are being increasingly recognized as important food components with nutritional value. However, the precise dietary recommendations for dietNAs are limited, because established methods for determining the quantity and nutritional role of dietNAs are still lacking. One of the …

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Regenerative Drug Discovery Using Ear Pinna Punch Wound Model in Mice

Paweł Sosnowski, Piotr Sass, Paulina Słonimska, Rafał Płatek et autres

The ear pinna is a complex tissue consisting of the dermis, cartilage, muscles, vessels, and nerves. Ear pinna healing is a model of regeneration in mammals. In some mammals, including rabbits, punch wounds in the ear pinna close spontaneously; in common-use laboratory …

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Impaired Generation of Transit-Amplifying Progenitors in the Adult Subventricular Zone of Cyclin D2 Knockout Mice

Rafał Płatek, Piotr Rogujski, Jarosław Mazuryk, Marta Barbara Wisniewska et autres

In the adult brain, new neurons are constitutively derived from postnatal neural stem cells/progenitors located in two neurogenic regions: the subventricular zone (SVZ) of the lateral ventricles (migrating and differentiating into different subtypes of the inhibitory interneurons of the olfactory bulbs), and …

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PTD4 Peptide Increases Neural Viability in an In Vitro Model of Acute Ischemic Stroke

Jarosław Mazuryk, Izabela Puchalska, Kamil Koziński, Magdalena J. Ślusarz et autres

Ischemic stroke is a disturbance in cerebral blood flow caused by brain tissue ischemia and hypoxia. We optimized a multifactorial in vitro model of acute ischemic stroke using rat primary neural cultures. This model was exploited to investigate the pro-viable activity of …

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Imunofan—RDKVYR Peptide—Stimulates Skin Cell Proliferation and Promotes Tissue Repair

Justyna Sawicka, Maria Dzierżyńska, Anna Wardowska, Milena Deptuła et autres

Regeneration and wound healing are vital to tissue homeostasis and organism survival. One of the biggest challenges of today’s science and medicine is finding methods and factors to stimulate these processes in the human body. Effective solutions to promote regenerative responses will …

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L1 Cell Adhesion Molecule Overexpression Down Regulates Phosphacan and Up Regulates Structural Plasticity-Related Genes Rostral and Caudal to the Complete Spinal Cord Transection

Rafał Płatek, Kamil Grycz, Angelika Więckowska‐Gacek, Julita Czarkowska‐Bauch et autres

L1 cell adhesion molecule (L1CAM) supports spinal cord cellular milieu after contusion and compression lesions, contributing to neuroprotection, promoting axonal outgrowth, and reducing outgrowth-inhibitory molecules in lesion proximity. We extended investigations into L1CAM molecular targets and explored long-distance effects of L1CAM rostral …

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Deciphering defective subventricular adult neurogenesis in cyclin D2-deficient mice

Rafał Płatek, Leszek Kaczmarek, Artur Czupryn

ABSTRACT Adult neurogenesis occurring in the brain of adult mammals is considered to have potential therapeutical applications. New neurons are produced constitutively from postnatal neural stem cells/precursors residing in two neurogenic regions: the subventricular zone (SVZ) of the lateral ventricles and the …

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AAV5-mediated overproduction of LUCAM down-regulates perineuronal nets encapsulating motoneurons and their phosphacan component after complete spinal cord transection in the rat

Kamil Grycz, Rafał Płatek, J Czrkowska-Bauch, Małgorzata Skup

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