Yanglu Li

Hypoxia-preconditioned hUCMSCs protect frozen-thawed human ovarian tissue by modulating the HIF-1α/VEGF pathway

Muqing Gu, Xiangyan Ruan, Jiaojiao Cheng, Yanglu Li et autres

OBJECTIVE: To evaluate whether hypoxia-preconditioned human umbilical cord mesenchymal stem cells (hUCMSCs) can protect frozen-thawed human ovarian tissue via in vitro co-culture. METHODS: ‑MSCs group (normoxia‑preconditioned hUCMSCs co-culture), and H‑MSCs group (hypoxia‑preconditioned hUCMSCs co-culture). Tissues in the co-culture groups were subjected to …

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Revascularization of human ovarian cortical grafts is not equally efficient from both sides of the cortex tissue

Jiaojiao Cheng, Xiangyan Ruan, Juan Du, Fengyu Jin et autres

Research question Does early-phase revascularization of human ovarian cortical grafts exhibit spatial asymmetry between medullary and cortical surfaces in a xenotransplantation model? Design Cryopreserved ovarian tissue from five patients was transplanted bilaterally beneath the renal capsule of immunodeficient nude mice (medullary surface …

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Effect of orlistat and anti-androgen oral contraceptives on pregnancy outcomes in overweight or obese PCOS patients during comprehensive interventions

Mingzhen Zhang, Xiangyan Ruan, Lingling Jiang, Yanglu Li et autres

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Prevention and treatment of iatrogenic POI using ovarian tissue cryopreservation and transplantation in patients with primary malignancies

Xiangyan Ruan, Lingling Jiang, Juan Du, Muqing Gu et autres

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First official clinical centre for ovarian cryopreservation in China

Muqing Gu, Xiangyan Ruan, Juan Du, Fengyu Jin et autres

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Evaluating the safety and efficacy of cryopreserved ovarian tissue transplantation in leukemia patients with different bone marrow remission status using xenotransplantation

Yanqiu Li, Xiangyan Ruan, Muqing Gu, Juan Du et autres

Background Leukemia patients undergoing cryopreserved ovarian tissue transplantation (OTT) may carry a high risk of disease induction. Measurable residual disease (MRD) in bone marrow is linked to an elevated risk of relapse. It is controversial whether leukemia patients must be allowed to …

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Practice guideline on ovarian tissue cryopreservation and transplantation in the prevention and treatment of iatrogenic premature ovarian insufficiency

Xiangyan Ruan, Xu Che, Hefeng Huang, Binghe Xu et autres

Premature ovarian insufficiency (POI) refers to the decline of ovarian function before the age of 40. POI causes a reduction in or loss of female fertility, accompanied by different degrees of menopausal symptoms, which increases the risk of chronic diseases related to …

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Corrigendum to “Virtual academy of women's health” [Glob Health J. 2022;6(4) 212–216]

T. Rabe, Yanglu Li, Xiangyan Ruan

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Ovarian tissue cryopreservation in a patient with breast cancer during pregnancy: a case report

Jiaojiao Cheng, Xiangyan Ruan, Juan Du, Fengyu Jin et autres

BACKGROUND: Fertility preservation using ovarian tissue cryopreservation (OTC) in patients with certain diseases, especially those needing chemo- or radiotherapy, is becoming routine in various Western countries. Our hospital is the first and until now the only centre in China to use this …

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Ovarian Tissue Cryopreservation in a Patient with Breast Cancer During Pregnancy: A Case Report

Jiaojiao Cheng, Xiangyan Ruan, Juan Du, Fengyu Jin et autres

Abstract Background: Fertility preservation using ovarian tissue cryopreservation (OTC) in patients with certain diseases especially needing chemo- or radiotherapy is becoming a routine management in various Western countries. Our hospital is the first and until now the only center in China using …

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Long-time low-temperature transportation of human ovarian tissue before cryopreservation

Jiaojiao Cheng, Xiangyan Ruan, Qi Gang Zhou, Yanglu Li et autres

RESEARCH QUESTION: Can the low-temperature transport time of removed human ovarian tissue be prolonged until cryopreservation? DESIGN: Fresh ovarian cortex from nine premenopausal patients was either slow-frozen immediately or stored at 4°C for 24 or 48 h before slow-freezing. The fresh and …

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Prevention and treatment of iatrogenic premature ovarian insufficiency: interpretation of the first Chinese guideline on ovarian tissue cryopreservation and transplantation

Xiangyan Ruan, Jiaojiao Cheng, Juan Du, Fengyu Jin et autres

In recent years, with the rapid development of medical research, cancer diagnosis and treatment technology have significantly improved young cancer patient's survival rate. Anticancer therapy such as chemotherapy, radiotherapy, or hematopoietic stem cell transplantation can lead to premature ovarian insufficiency. The endocrine …

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