Arnaud Guillé

Invasive lobular carcinoma uncovers mobilized yet dysfunctional immunity driven by tumor-stroma crosstalk and antigen presentation defects

Maelle Picard, Pascal Finetti, Arnaud Guillé, Gwénaël Lumet et autres

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TERT drives liver tumorigenesis beyond telomere elongation

Laura Braud, Julien Vernerey, Arnaud Guillé, Pierre Cordier et autres

We generated two mouse models, p21 +/Tert and p21 +/TertCi , expressing either telomerase reverse transcriptase (Tert) or a catalytically inactive variant under the control of the p21 promoter. By 18–20 mo of age, ∼15% of mice from both genotypes developed liver …

fr, us, cn (code pays fourni par la source)

Multiomic dissection of HR + /HER2 − invasive lobular breast carcinoma reveals mobilized yet dysfunctional anti-tumor immunity shaped by tumor-stroma crosstalk and impaired antigen presentation

Maelle Picard, Pascal Finetti, Arnaud Guillé, Gwénaël Lumet et autres

Abstract Context Immunotherapy based on immune checkpoint inhibitors (ICI) revolutionized the treatment of triple-negative (TN) breast carcinomas (BC), but remains more challenging in HR + /HER2 - BCs. Because invasive lobular carcinomas (ILC) generally exhibit low immune infiltration, ICIs were largely overlooked …

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TERT drives liver tumorigenesis beyond telomere elongation

Laura Braud, Julien Vernerey, Arnaud Guillé, Pierre Cordier et autres

Abstract We generated two mouse models, p21 ⁺/Tert and p21 ⁺/TertCi , expressing either telomerase reverse transcriptase (TERT) or a catalytically inactive variant under the control of the p21 promoter. By 18–20 months of age, approximately 25% of mice from both genotypes …

fr, us, cn (code pays fourni par la source)

Multiomic analysis of colorectal adenocarcinoma reveals a new subtype of myofibroblastic cancer-associated fibroblasts that express high levels of B7-H3 and have poor-prognosis value

Maelle Picard, Arnaud Guillé, Pascal Finetti, Bernadette de Rauglaudre et autres

Background The high mortality rate of patients with colorectal cancer combined with the lack of nontoxic and efficient personalized treatments makes it urgent to develop new targeted therapies for this disease. B7-H3 appears to be a good target, as it is overexpressed …

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Multi-omic analysis of colorectal adenocarcinoma identifies a new subtype of myofibroblastic cancer-associated fibroblast expressing high level of B7-H3 and with poor prognosis value

Maelle Picard, Arnaud Guillé, Pascal Finetti, Bernadette de Rauglaudre et autres

Abstract The high mortality rate of colorectal cancer (CRC) combined with the lack of non-toxic and efficient personalized treatments makes it urgent to develop new targeted therapies for this disease. B7-H3 appears to be a good target as it is overexpressed in …

fr (code pays fourni par la source)

Dasatinib overcomes AML cells resistant to BCL2 inhibition by degrading MCL1

Sylvain Garciaz, Camille Montersino, Maxence Bourgoin, Arnaud Jacquel et autres

Acute myeloid leukaemia (AML) is a severe disease occurring mainly in the elderly population. Venetoclax (VEN) combined with azacitidine has changed the paradigm of treatment of AML. Nevertheless, approximately 30% of patients are primary refractory to VEN (VEN-R), with no current therapeutic …

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A benchmarking study of individual somatic variant callers and voting-based ensembles for whole-exome sequencing

Arnaud Guillé, José Adélaı̈de, Pascal Finetti, Fabrice André et autres

By identifying somatic mutations, whole-exome sequencing (WES) has become a technology of choice for the diagnosis and guiding treatment decisions in many cancers. Despite advances in the field of somatic variant detection and the emergence of sophisticated tools incorporating machine learning, accurately …

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Decoding the pathological and genomic profile of epithelial ovarian cancer

Rim Rejaibi, Arnaud Guillé, Maroua Manai, José Adélaı̈de et autres

Ovarian cancer (OC) is one of the most common cancers in women, with a high mortality rate. Most of published studies have been focused on Caucasian populations, with the need to explore biological features and clinical outcomes of patients from other ethnicities. …

Tunisie, fr (code pays fourni par la source)

Dasatinib Overcomes AML Resistance to BCL2 Inhibition By Indirectly Inhibiting MCL1: From Ex Vivo drug Sensitivity/Resistance Profiling to a Phase II Clinical Trial: A Hemato-BIO Study

Sylvain Garciaz, Rémy Castellano, Arnaud Jacquel, Arnaud Guillé et autres

Introduction. BH3 mimetics such as the BCL2 specific inhibitor (-inh) venetoclax (VEN) and the BCL2/BLCxL-inh navitoclax (NAV), are small molecules inducing intrinsic apoptotic cell death by inhibiting antiapoptotic proteins. VEN has changed the paradigm of treatment of acute myeloid leukemia (AML) unfit …

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Whole-exome profiles of inflammatory breast cancer and pathological response to neoadjuvant chemotherapy

François Bertucci, Arnaud Guillé, Florence Lerebours, Michele Ceccarelli et autres

BACKGROUND: Neoadjuvant chemotherapy (NACT) became a standard treatment strategy for patients with inflammatory breast cancer (IBC) because of high disease aggressiveness. However, given the heterogeneity of IBC, no molecular feature reliably predicts the response to chemotherapy. Whole-exome sequencing (WES) of clinical tumor …

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Follicular lymphoma comprises germinal center–like and memory-like molecular subtypes with prognostic significance

Camille Laurent, Preeti Trisal, Bruno Tesson, Sahil Seth et autres

ABSTRACT: A robust prognostic and biological classification for newly diagnosed follicular lymphoma (FL) using molecular profiling remains challenging. FL tumors from patients treated in the RELEVANCE trial with rituximab-chemotherapy (R-chemo) or rituximab-lenalidomide (R2) were analyzed using RNA sequencing, DNA sequencing, immunohistochemistry (IHC), …

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