Maria Elena Bracaccia

Dapagliflozin modulates diabetic kidney disease through indirect transcriptional regulation rather than direct transcriptional reversal

Francesco Pesce, Camillo Tancredi Strizzi, Antonio Granata, Maria Elena Bracaccia et autres

BACKGROUND: Diabetic kidney disease (DKD) is the leading cause of kidney failure worldwide. While sodium-glucose co-transporter 2 inhibitors (SGLT2i) confer remarkable renoprotection, the molecular mechanisms underlying their efficacy remain incompletely understood. METHODS: We performed an integrative cross-species transcriptomic analysis comparing dapagliflozin-modulated signatures …

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#3502 Predicting mortality in unplanned hemodialysis

Camillo Tancredi Strizzi, Ilaria Mariani, Elettra Lomeo, Maria Elena Bracaccia et autres

Abstract Background and Aims The unplanned initiation of hemodialysis is a pivotal event often associated with a heightened risk of in-hospital and short-term mortality. Identifying modifiable predictors of such outcomes is essential to refine clinical decision-making and reduce the burden of futile …

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#2445 Trends in diagnosis, renal progression, and therapeutic impact on survival in AL amyloidosis

Maria Grazia Chiappini, Camillo Tancredi Strizzi, Maria Luisa Muci, Valentina Vaiarello et autres

Abstract Background and Aims Progressive renal dysfunction is a hallmark of AL amyloidosis and a key determinant of prognosis. Early diagnosis and effective management strategies are critical to improving outcomes. This single-center retrospective study evaluates the clinical course of 104 patients (64 …

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Epitope Spreading in Immune-Mediated Glomerulonephritis: The Expanding Target

Camillo Tancredi Strizzi, Martina Ambrogio, Francesca Zanoni, Bibiana Bonerba et autres

Epitope spreading is a critical mechanism driving the progression of autoimmune glomerulonephritis. This phenomenon, where immune responses broaden from a single epitope to encompass additional targets, contributes to the complexity and severity of diseases such as membranous nephropathy (MN), lupus nephritis (LN), …

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#2733 Osteoporosis and CKD-MBD in hemodialysed patients: efficacy and safety of denosumab

Maria Elena Bracaccia, Alessandra Moioli, Claudia Fofi, Paolo Mené et autres

Abstract Background and Aims Osteoporosis is a chronic progressive disease characterized by low bone mass and deterioration of bone tissue which results in a rapid increase in fracture risk. Osteoporosis in hemodialysed patients with Chronic Kidney Disease – Mineral and Bone Disorder …

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Determinants of immunosuppressive therapy in renal transplant recipients: an Italian observational study (the CESIT project)

Alessandro C Rosa, Marco Finocchietti, Nera Agabiti, Paolo Mené et autres

BACKGROUND: Very scanty evidence is available on factors influencing the choice of immunosuppressive drug therapy after kidney transplantation. METHODS: An Italian multiregional real-world study was conducted integrating national transplant information system and claims data. All patients undergoing kidney transplantation for the first …

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Safety and efficacy of COVID-19 vaccines in patients on dialysis: a multicentre cohort study in Italy

Francesca Menniti‐Ippolito, Alfonso Mele, Roberto Da, Salvatore De Masi et autres

BACKGROUND: The aim of this study was to evaluate the efficacy and safety of COVID-19 vaccines in patients undergoing haemodialysis in Italy compared to the general population. METHODS: In this cohort study, 118 dialysis centres from 18 Italian Regions participated. Individuals older …

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Determinants of immunosuppressive therapy in renal transplant recipients: an Italian observational study (the CESIT project)

Alessandro C. Rosa, Marco Finocchietti, Nera Agabiti, Paolo Mené et autres

Abstract Background Very scanty evidence is available on factors influencing the choice of immunosuppressive drug therapy after kidney transplantation. Methods. An Italian multiregional real-world study was conducted integrating national transplant information system and claims data. All patients undergoing kidney transplantation for the …

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MO240A FATAL CASE OF VASCULITIS AFTER SARS-COV-2 NEGATIVIZATION

Maria Elena Bracaccia, Nicolò De Cicco, Alessandra Moioli, Simona Barberi et autres

Abstract Background and Aims Spectrum of acute severe respiratory syndrome Coronavirus 2 (SARS-CoV-2) ranges from mild to critical and probably mortality rate is largely underestimated. Complications may represent different manifestation of a profound endothelial dysfunction and injury. Biopsies reveal macro and microvascular …

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Tumour-infiltrating cytotoxic T lymphocytes in somatotroph pituitary neuroendocrine tumours

Donato Iacovazzo, Sabrina Chiloiro, Eivind Carlsen, Antonio Bianchi et autres

INTRODUCTION: Somatotroph pituitary tumours are often resistant to first-generation somatostatin analogues and can invade the surrounding structures, limiting the chances of curative surgery. Recent studies suggested that the immune microenvironment and pro-angiogenic factors can influence neuroendocrine tumour prognosis. In this study, we …

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Biochemical normalization in acromegaly after 79 months' treatment with Pasireotide: case report

Chiara Bima, Sabrina Chiloiro, Donato Iacovazzo, Tommaso Tartaglione et autres

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Bone metabolism in acromegaly

Antonella Giampietro, Sabrina Chiloiro, Marilda Mormando, Chiara Bima et autres

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)