Tommaso Tartaglione

Optoacoustic molecular signatures of muscle involvement in facioscapulohumeral dystrophy compared to conventional imaging

Mauro Monforte, Sara Bortolani, Davide Marchese, Beatrice Ravera et autres

Abstract Background and Objectives Facioscapulohumeral muscular dystrophy (FSHD) is characterised by asynchronous muscle degeneration and marked pathological heterogeneity. While conventional MRI can detect fatty replacement and oedema-like abnormalities, it provides limited insight into other relevant biological processes such as extracellular matrix remodelling …

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Can acromegaly be controlled in all cases?

Sabrina Chiloiro, Francesco Padovano Sorrentino, Alessandra Vicari, Antonella Giampietro et autres

Acromegaly is a rare disease, due in most of the cases to a growth hormone (GH)-secreting pituitary adenoma (PA), namely neuroendocrine tumour (PitNET). The treatment of patients with acromegaly is multimodal and multi-step, including surgery, medical therapies, and radiotherapy. In the last …

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EP1146 - ECE_2526 - Long-term treatment with first-generation somatostatin receptor ligands in acromegaly: predictors of dose reduction and withdrawal

Chiara Palumbo, Sabrina Chiloiro, Antonella Giampietro, Pier Paolo Mattogno et autres

Abstract Introduction In acromegaly, therapy with first-generation somatostatin receptor ligands (fgSRLs) plays a central role, especially in patients who do not achieve surgical remission. We have observed that long-term use of fgSRLs, may allow, in some patients, a progressive dose reduction and …

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Survival outcomes after orbital exenteration for recurrent or previously treated orbital malignancies: impact of margin status and metastatic spread

Mattia Todaro, F. Perquoti, F. De Lorenzis, Giulio Gasparini et autres

BACKGROUND: Orbital exenteration is a radical procedure used in selected orbital malignancies, yet survival outcomes vary widely, particularly in recurrent or previously treated disease. We evaluated the association of pathological stage (nodal and/or distant metastasis status) and margin status with overall survival …

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Pitfalls in the Diagnosis of Pituitary Germinoma in a Case of Klinefelter Syndrome: Case Report and Literature Review

Sabrina Chiloiro, Amato Infante, Carmelo Caldarella, Salvatore Raia et autres

In this case report, we described the pitfalls in the differential diagnosis of a pituitary stalk lesion in a patient affected by Klinefelter Syndrome (KS) that was initially suspected of infundibulo-neuro-hypophysitis (INH). According to the atypical radiological picture for INH, the not-conclusive …

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Post‐mortem CT detection of fatal air embolism after aerosolized fibrin glue for bladder bleeding

Béatrice Benedetti, Nazario Foschi, C Pesaresi, Tommaso Tartaglione et autres

Radiation-induced hemorrhagic cystitis (RHC) is a severe complication of pelvic radiotherapy, often used to treat various pelvic malignancies. Despite multiple therapeutic options, including conservative and invasive interventions, the optimal management remains uncertain. We report the case of a 76-year-old male with pulmonary …

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The clinicopathological PANOMEN-3 classification predicts pituitary adenoma prognosis: a real-world retrospective single center study of a surgically treated cohort

Sabrina Chiloiro, Antonella Giampietro, Raffaele Migliore, Chiara Saroli Palumbo et autres

INTRODUCTION: Pituitary adenomas (PAs) are generally benign neoplasms, though in rare cases may exhibit aggressive behavior. In 2024, the PANOMEN-3 workshop released a new clinical-pathological classification. The objective of this study was to examine the potential of the PANOMEN-3 classification to predict …

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The Role of Multidisciplinary Ocular and Periocular Cancers Meetings in Uveal Melanoma Management: A 2-Year Analysis

Gustavo Savino, Monica Maria Pagliara, Maria Grazia Sammarco, Carmela Grazia Caputo et autres

Purpose: The objective of this study was to evaluate the implementation of a Multidisciplinary Tumor Board (MDTB) strategy in the treatment of patients with uveal melanoma. Methods: A retrospective analysis was conducted on the implementation of MDTB meetings over a 24-month period. …

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Lights or shadows, a promising future for positron emission tomography in pituitary tumors: a systematic review

Sabrina Chiloiro, Carmelo Caldarella, Alessandra Rosa Vicari, Simone Antonio De Sanctis et autres

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Breast Cancer Orbital Metastases: Clinical and Histopathological Characteristics, Imaging Features, and Disease-Related Survival in a Multicentric Retrospective Case Series

Sofia Peschiaroli, Adriana Iuliano, Giovanni Cuffaro, Francesco M. Quaranta Leoni et autres

Background: This study aims to analyze the clinical, radiological, and histopathological features, as well as the long-term follow-up, of patients with breast carcinoma orbital metastases. Methods: The study was a multicentric retrospective observational case series. The medical records of 32 female patients …

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Natural history of facioscapulohumeral muscular dystrophy evaluated by multiparametric quantitative MRI: a prospective cohort study

Matteo Paoletti, Mauro Monforte, L. Barzaghi, Giorgio Tasca et autres

BACKGROUND: Facioscapulohumeral muscular dystrophy (FSHD) is a genetic disorder characterized by progressive skeletal muscle wasting. Longitudinal muscle magnetic resonance imaging (MRI) studies demonstrated that the risk of developing irreversible fatty replacement is higher in muscles showing edematous lesions. The quantification of this …

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A Toluene-induced Infundibulo-neuro-hypophysitis: Presentation of a New Cause of Hypophysitis Secondary to Toxic Exposure and Review on Toluene Inhalation Endocrine Effects

Flavia Costanza, Antonella Giampietro, Tommaso Tartaglione, Flavia Angelini et autres

INTRODUCTION: Hypophysitis is a rare inflammatory disorder of the pituitary gland. Symptoms and signs of hypophysitis can be various, progressing insidiously, and its recognition may be challenging. CASE PRESENTATION: We report the clinical history and therapeutic management of a 59-year-old man diagnosed …

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