Antonín Škoch

Sex-stratified fixel-based analysis reveals reduced frontal fibre density in males with first-episode of psychosis

Stella M. Sánchez, Helmut Schmidt, Antonín Škoch, Kenneth Hugdahl et autres

Background: Schizophrenia has been conceptualised as a disorder of brain disconnectivity, with white matter abnormalities contributing to altered neural communication. However, fibre-specific white matter alterations in early illness and their potential sex-related differences remain insufficiently characterised. We applied fixel-based analysis to investigate …

cz, no (code pays fourni par la source)

An ENIGMA Consortium study of the relationship between white matter microstructure and positive and negative symptom severity in patients with schizophrenia

Aoife Warren, Laurena Holleran, Ingrid Agartz, Ole Andreas Andreassen et autres

Symptom severity in schizophrenia has been repeatedly associated with thinner cortical gray matter. While global and regional white matter microstructure alterations in schizophrenia are well-documented, their association with clinical symptom severity remains unclear. As this is likely due to methodological heterogeneity across …

ie, no, it, au, us, jp, cz, gb, sg (code pays fourni par la source)

Structural brain abnormalities and aggression in schizophrenia: mega-analysis of data from 2095 patients and 2861 healthy controls via the ENIGMA consortium

Jelle Lamsma, Adrian Raine, Seyed Mostafa Kia, Wiepke Cahn et autres

nl, us, de, it, sg, kr, gb, ca, ch, au, ru, es, cz (code pays fourni par la source)

Characterising Structural Brain Connectivity of Patients with First Episode of Psychosis

Stella M. Sánchez, Thomas R. Knösche, Petra Fürstová, Antonín Škoch et autres

Abstract BACKGROUND AND HYPOTHESIS Schizophrenia is associated with widespread neuroanatomical abnormalities affecting both grey matter and white matter (WM). Early symptoms are often linked to dysfunctions in the frontal cortex and the temporal lobe. This study investigates WM disruptions and explores how …

cz, de, us (code pays fourni par la source)

Estimating Multimodal Structural Brain Variability in Schizophrenia Spectrum Disorders: A Worldwide ENIGMA Study

Wolfgang Omlor, Finn Rabe, Simon Fuchs, Werner Surbeck et autres

OBJECTIVE: The clinical diversity of schizophrenia is reflected by structural brain variability. It remains unclear how this variability manifests across different gray and white matter features. In this meta- and mega-analysis, the authors investigated how brain heterogeneity in schizophrenia is distributed across …

ch, us (code pays fourni par la source)

Enlarged brain perivascular spaces correlate with blood plasma osmolality in the healthy population: A longitudinal study

Alexandra Morozova, Filip Španiel, Antonín Škoch, Marek Brabec et autres

• Blood plasma osmolality inversely correlates with EPVS volume in the healthy population. • EPVS volume increases with age even in the relatively young people. • There is substantial inter-individual variability in EPVS load. • EPVS distribution exhibits individual asymmetry across hemispheres. …

cz, us, es (code pays fourni par la source)

Evaluation of microstructural brain changes in post-coronavirus disease 2019 (COVID-19) patients with neurological symptoms: a cross-sectional study

Ibrahim Ibrahim, Antonín Škoch, Monika Dezortová, Theodor Adla et autres

Background: Changes in both the vascular system and brain tissues can occur after a prior episode of coronavirus disease 2019 (COVID-19), detectable through modifications in diffusion parameters using magnetic resonance imaging (MRI) techniques. These changes in diffusion parameters may be particularly prominent …

cz (code pays fourni par la source)

Neurostructural subgroup in 4291 individuals with schizophrenia identified using the subtype and stage inference algorithm

Yuchao Jiang, Cheng Luo, Jijun Wang, Lena Palaniyappan et autres

Machine learning can be used to define subtypes of psychiatric conditions based on shared biological foundations of mental disorders. Here we analyzed cross-sectional brain images from 4,222 individuals with schizophrenia and 7038 healthy subjects pooled across 41 international cohorts from the ENIGMA, …

cn, ca, de, jp, no, tw, us, es, it, tr, sg, au, kr, ch, cz (code pays fourni par la source)

Cholinergic modulation supports dynamic switching of resting state networks through selective DMN suppression

Pavel Šanda, Jaroslav Hlinka, Monica van den Berg, Antonín Škoch et autres

Brain activity during the resting state is widely used to examine brain organization, cognition and alterations in disease states. While it is known that neuromodulation and the state of alertness impact resting-state activity, neural mechanisms behind such modulation of resting-state activity are …

cz, be, us, gr (code pays fourni par la source)

Longitudinal assessment of ventricular volume trajectories in early-stage schizophrenia: evidence of both enlargement and shrinkage

Patrik Švancer, Václav Čapek, Antonín Škoch, Miloslav Kopeček et autres

BACKGROUND: Lateral ventricular enlargement represents a canonical morphometric finding in chronic patients with schizophrenia; however, longitudinal studies elucidating complex dynamic trajectories of ventricular volume change during critical early disease stages are sparse. METHODS: We measured lateral ventricular volumes in 113 first-episode schizophrenia …

cz, jp (code pays fourni par la source)

Structural brain abnormalities and aggressive behaviour in schizophrenia: Mega-analysis of data from 2095 patients and 2861 healthy controls via the ENIGMA consortium

Jelle Lamsma, Adrian Raine, Seyed Mostafa Kia, Wiepke Cahn et autres

Abstract Background Schizophrenia is associated with an increased risk of aggressive behaviour, which may partly be explained by illness-related changes in brain structure. However, previous studies have been limited by group-level analyses, small and selective samples of inpatients and long time lags …

nl, us, de, it, sg, kr, gb, ca, ch, au, ru, es, cz (code pays fourni par la source)

Time is the enemy: Negative symptoms are related to even slight differences in the duration of untreated psychosis

Andrea Slováková, Jan Kúdelka, Antonín Škoch, Lea Jakob et autres

BACKGROUND: Negative symptoms (NS) represent a detrimental symptomatic domain in schizophrenia affecting social and occupational outcomes. AIMS: We aimed to identify factors from the baseline visit (V1) - with a mean illness duration of 0.47 years (SD = 0.45) - that predict …

cz (code pays fourni par la source)