Filip Španiel

Medium-term prediction of clinically relevant outcomes in first-episode schizophrenia patients

Eduard Bakštein, Jan Kudelka, Jakub Schneider, Andrea Slováková et autres

Background Predicting long-term outcomes in first-episode schizophrenia (FES) remains difficult, despite being especially important early in the illness, when timely intervention is most critical. It also remains unclear how much data from the initial phase of illness is required to improve prognostic …

cz, jp (code pays fourni par la source)

Rest-Activity Rhythm Variability Across Clinical Episodes of Bipolar Disorder: Standalone Biomarker or Statistical Artifact?

Carmen-Anna Konicarová, Jakub Schneider, Marián Kolenič, Filip Španiel et autres

Abstract Background Actigraphy-derived rest–activity rhythm (RAR) features are widely used to characterize clinical states in bipolar disorder (BD). Both mean levels and temporal variability of these features have been associated with mood episodes; however, variability measures are often statistically coupled with the …

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Special Issue: Does latent Toxoplasma infection mimic the immune profile of schizophrenia? Sex-specific cytokine and brain-marker alterations suggest partial overlap

Jaroslav Flegr, Jana Ullmann, Filip Španiel, Ján Toman et autres

Schizophrenia often features low-grade neuroinflammation. Because latent toxoplasmosis (LT) is more prevalent among individuals with schizophrenia, we tested whether LT yields a biomarker pattern resembling that reported in schizophrenia. We quantified 15 cytokines and 15 blood markers of brain injury in 65 …

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Does latent Toxoplasma infection mimic the immune profile of schizophrenia? Sex-specific cytokine and brain-marker alterations suggest partial overlap

Jaroslav Flegr, Jana Ullmann, Filip Španiel, Ján Toman et autres

Abstract Background Schizophrenia often features low-grade neuroinflammation. Because latent toxoplasmosis (LT) is common in this population, we tested whether LT yields a biomarker pattern resembling that reported in schizophrenia. Methods We quantified 15 cytokines and 15 blood markers of brain injury in …

cz, jp (code pays fourni par la source)

Structural brain abnormalities and aggression in schizophrenia: mega-analysis of data from 2095 patients and 2861 healthy controls via the ENIGMA consortium

Jelle Lamsma, Adrian Raine, Seyed Mostafa Kia, Wiepke Cahn et autres

nl, us, de, it, sg, kr, gb, ca, ch, au, ru, es, cz (code pays fourni par la source)

TRUSTING: An International Multicenter Observational Study of Speech-Based Relapse Prediction in Psychosis Using Explainable AI

Roya Melanie Hüppi, Giacomo Cecere, Sandra Anna Just, Sanne Koops et autres

ABSTRACT Introduction The course of psychotic disorders typically involves relapses. Early warning signs vary between individuals and are difficult to detect in clinical practice, especially in outpatient settings. Speech provides a quantitative clinical marker for detecting such early warning signs. The EU …

ch, de, no, nl, tr, ie, us, be, cz, es (code pays fourni par la source)

Neuroimaging Correlates of Altered Sense of Agency in First-Episode Schizophrenia-Spectrum Patients: A Comparative Study Across Two Sites

Karolina Volfikova, David Tomeček, Filip Španiel, Jaroslav Tintěra et autres

Abstract Background Disturbances in the sense of agency are a key marker of schizophrenia and are closely linked to core symptoms such as hallucinations and delusions of influence. Neuroimaging studies have implicated cortical midline structures and the defaul t mode network (DMN) …

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Impact of Connectivity Granularity: A Comparison of ROI and Network-Level Approaches for Early Schizophrenia Classification

David Tomeček, Dominik Klepl, Zbyněk Pitra, Jiřı́ Horáček et autres

Abstract While schizophrenia diagnosis relies on clinical interviews, there is growing interest in neuroimaging-based computational tools to aid classification. In particular, resting-state fMRI-derived functional connectivity has been explored as a potential biomarker, with applications not only in supporting clinical assessment but also …

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Infra-slow frequency oscillations propagating through multiple organs convey information on phase-specific timing for self-initiated actions

Filip Španiel, Jiří Anýž, Dominika Grygarová, Jan Hubený et autres

Cognitive functions crucial for voluntary actions fluctuate with infra-slow frequencies (ISF, <0,2 Hz), indicating their potential impact with self-driven behavior. ISF's involvement in brain-body interaction suggests that the link between ISF oscillations and self-initiated actions can be explored through low-frequency physiological readouts …

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The ILIA study: protocol for a randomized-controlled multicenter clinical trial on smartphone- and web-based relapse monitoring for patients with schizophrenia or schizoaffective disorder

Selina Hiller, Laura Emde, Denise Jais, Soňa Sikorová et autres

BACKGROUND: Despite the proven efficacy of antipsychotics in relapse prevention in schizophrenia and schizoaffective disorder, every third patient experiences a relapse within less than one year. Relapses can worsen psychosocial and treatment related outcomes and lead to substantial economic costs, primarily due …

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Increased Delta/Beta Ratio Index in NREM3 Sleep as a Potential Electrophysiological Marker of Reverse Sleep State Misperception in Patients with Early-Stage Schizophrenia

Radana Měrková, Eva Miletínová, Marek Piorecký, Tereza Czesany Dvořáková et autres

Sleep state misperception describes a mismatch between subjective and objective sleep parameters. While insomnia patients typically overestimate sleep onset latency (SOL) and wake after sleep onset, and underestimate total sleep time (TST), the opposite pattern—reverse misperception—has been reported in schizophrenia but remains …

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Antipsychotics Lower Peripheral Markers of Inflammation in Drug-naïve Early Psychosis: A Pilot Study

Nicole Safarova, Marián Kolenič, Ivana Tašková, Václav Čapek et autres

Abstract Introduction Neuroinflammation is increasingly recognized as a core pathophysiological mechanism in schizophrenia and can be indirectly assessed through peripheral inflammatory markers. Therefore, this pilot study investigated the impact of antipsychotic treatment on inflammation in patients with first-episode psychosis (FEP) who were …

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