Structure and Biosynthesis of Aridomycins Reveal a Glycosylated Prodrug Strategy for Self-Resistance
Hongbing Liu, Shannon I. Ohlemacher, Robert O’Connor, Rahim Rajwani et autres
Polyketides, nonribosomal peptides, and their hybrids constitute a major class of clinically important antibiotics. To avoid self-toxicity, producing organisms must employ mechanisms of self-resistance. Here, we describe the structures, biosynthesis, and self-resistance strategy of the aridomycins, new linear polyketide antibiotics. Using NMR …
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4 citations
Journal of the American Chemical Society