Shouhei Yokota

Prospective evaluation of minimal residual disease monitoring to predict prognosis of adult patients with Ph‐negative acute lymphoblastic leukemia

Koji Nagafuji, Toshihiro Miyamoto, Tetsuya Eto, Ryosuke Ogawa et autres

OBJECTIVE: We investigated whether minimal residual disease (MRD) status in adult patients with Philadelphia chromosome (Ph)-negative acute lymphoblastic leukemia (ALL) is useful for decision on clinical indications for allogeneic hematopoietic stem cell transplantation (HSCT). METHODS: We prospectively monitored MRD after induction and …

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Minimal Residual Disease (MRD) Status after Induction Therapy Is a Strong Prognostic Factor in the Treatment of Adult Ph (-) Acute Lymphoblastic Leukemia (ALL): Results of a Prospective Study (ALL MRD2008 Study)

Koji Nagafuji, Toshihiro Miyamoto, Tetsuya Eto, Ryosuke Ogawa et autres

Abstract Introduction A clinical indication for allogeneic hematopoietic stem cell transplantation (HSCT) in adult Philadelphia-chromosome negative [Ph (-)] acute lymphoblastic leukemia (ALL) patients in complete remission 1 (CR1) remains to be clarified. Minimal residual disease (MRD) status has been reported to be …

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Augmented Consolidation Therapy Based on Minimal Residual Disease (MRD) and Analysis of the Measurement of Sequential MRD in Childhood Acute Lymphoblastic Leukemia : Children's Cancer and Leukemia Study Group of JAPAN (CCLSG), Cclsg ALL 2004 Protocol Study

Arata Watanabe, Toshinori Hori, Yasuto Shimomura, Chihaya Imai et autres

Abstract BACKGROUND: Minimal residual disease (MRD) level after induction (Time Point1:TP1) and before consolidation therapy (Time Point2:TP2) has a strong impact in prediction of outcome for childhood acute lymphoblastic leukemia and it has clinical utility of a prognostic factor to stratify the …

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Favorable Event Free-Survival of High-Dose Chemotherapy followed by Autologous Hematopoietic Stem Cell Transplantation for Higher Risk Diffuse Large B-Cell Lymphoma in First Complete Remission

Hiroto Kaneko, Yasuhiko Tsutsumi, Takahiro Fujino, Saeko Kuwahara et autres

High-dose chemotherapy followed by autologous stem cell transplantation (ASCT) has been applied to patients with diffuse large Bcell lymphoma (DLBCL); it is well established that ASCT shows significant survival benefits for chemosensitive relapse. However, half of relapsed patients are resistant to salvage …

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Inversion of chromosome 7q22 and q36 as a sole abnormality presenting in myelodysplastic syndrome: a case report

Hiroto Kaneko, Kazuho Shimura, Saeko Kuwahara, Muneo Ohshiro et autres

INTRODUCTION: Deletions of chromosome 7 are often detected in myelodysplastic syndrome. The most commonly deleted segments are clustered at band 7q22. A critical gene is therefore suggested to be located in this region. We report a patient with myelodysplastic syndrome whose marrow …

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Monitoring of minimal residual disease (MRD) is useful to predict prognosis of adult patients with Ph-negative ALL: results of a prospective study (ALL MRD2002 Study)

Koji Nagafuji, Toshihiro Miyamoto, Tetsuya Eto, Tomohiko Kamimura et autres

BACKGROUND: Allogeneic hematopoietic stem cell transplantation (HSCT) for patients with Philadelphia chromosome (Ph)-negative acute lymphoblastic leukemia (ALL) in first complete remission (CR1) is much more intensive than multi-agent combined chemotherapy, although allogeneic HSCT is associated with increased morbidity and mortality when compared …

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Minimal Residual Disease Negative Status At the End of Induction Therapy Is a Potent Prognostic Marker in Adult Non-Ph Acute Lymphoblastic Leukemia: Results of the ALL MRD2002 Study

Koji Nagafuji, Toshihiro Miyamoto, Tetsuya Eto, Tomohiko Kamimura et autres

Abstract Abstract 2581 Introduction A clinical indication for allogeneic hematopoietic stem cell transplantation (HSCT) in adult Philadelphia-chromosome negative [Ph (−)] acute lymphoblastic leukemia (ALL) patients in complete remission 1 (CR1) remains to be clarified. An international study showed that matched related donors …

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Pure red cell aplasia caused by parvovirus B19 in two patients without chronic hemolysis

Hiroto Kaneko, Kazuho Shimura, Koichi Nishida, Yasuo Ohkawara et autres

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Cytogenetic Evidence for a Clonal Involvement of Granulocyte-Macrophage and Erythroid Lineages in a Patient with Refractory Anaemia

Tsukasa Okuda, Shouhei Yokota, Taira Maekawa, Yoshiaki Sonoda et autres

To investigate the clonal origin of refractory anaemia, we carried out cytogenetic studies on single haematopoietic colonies derived from granulocyte-macrophage precursors (CFU-GM) and erythroid precursors (BFU-E). Marrow cells from a patient with refractory anaemia revealed the coexistence of a normal and an …

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Protein-Losing Enteropathy in a Case of Nodal Follicular Lymphoma without a Gastrointestinal Mucosal Lesion

Hiroto Kaneko, Mihoko Yamashita, Muneo Ohshiro, Yasuo Ohkawara et autres

Protein-losing enteropathy (PLE) is characterized by gastrointestinal loss of serum protein. It is usually caused by hypersecretion from a tumor, ulcer, or long standing lymphangiectasia. However, we report a 47-year-old man of peritoneal nodal follicular lymphoma who developed PLE with none of …

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Simultaneous complication of multiple myeloma with Sjögren syndrome.

Hiroto Kaneko, Yasuo Ohkawara, Kouichi Taniguchi, Yousuke Matsumoto et autres

We report a 72-year-old female case of IgG-kappa type multiple myeloma (MM) simultaneously complicated with Sjögren syndrome (SS). She also presented marked hyperamylasemia of salivary-type isozyme. Although she had received sequential chemotherapy completed with high-dose therapy with autologous hematopoietic stem cell transplantation, …

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Clonotypic analysis of acute lymphoblastic leukemia with a double TEL-AML1 fusion at onset and relapse

Takeshi Inukai, Shouhei Yokota, Tomomi Okamoto, Atsushi Nemoto et autres

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