Yasuto Shimomura

Outcomes following induction failure in Japanese children with acute lymphoblastic leukemia

Chihaya Imai, Atsushi Satō, Mitsuteru Hiwatari, Yasuto Shimomura et autres

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Case Report: Acquired Generalized Anhidrosis Caused by Brain Tumor: Review of the Literature

Kohei Kawahara, Yasuto Shimomura, Yuichiro Oshima, Tadashi Watanabe et autres

Purpose: There has been limited focus on sweating failure in patients with brain tumor. We report two patients with generalized anhidrosis caused by germinoma. We also review previous reports of generalized anhidrosis due to brain tumor. Case Reports: Patient 1 was a …

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Hypersensitivity reaction to high-dose methotrexate and methotrexate-induced acral erythema in a child with acute lymphoblastic leukemia

Mitsuko Akaihata, Kenji Miyata, Yasuto Shimomura, Toshinori Hori et autres

A 9-year-old boy with acute lymphoblastic leukemia experienced a hypersensitivity reaction (HSR) and acral erythema upon receiving high-dose methotrexate (HDMTX). Both HSR and acral erythema are uncommon adverse events of MTX therapy, and MTX has not been reported to cause HSRs in …

Subcortical infarction in a young adult with Hunter syndrome

Motoya Kimura, Yoshiteru Azuma, Soutarou Taguchi, Mizuki Takagi et autres

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Surgical management of steroid‐induced glaucoma in a child with leukemia

Mitsuko Akaihata, Hiroaki Somiya, Yasuto Shimomura, Toshinori Hori et autres

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Harlequin syndrome associated with ganglioneuroblastoma-induced Horner syndrome

Kenji Miyata, Mitsuko Akaihata, Yasuto Shimomura, Toshinori Hori et autres

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In-Hospital Management Might Reduce Induction Deaths in Pediatric Patients With Acute Lymphoblastic Leukemia: Results From a Japanese Cohort

Shunsuke Nakagawa, Motohiro Kato, Toshihiko Imamura, Chihaya Imai et autres

Induction deaths (ID) remain a critical issue in the treatment of pediatric patients with acute lymphoblastic leukemia (ALL). The reported rate of ID in this population is 1% or higher. We speculate that this proportion might be lower in Japan because of …

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White Blood Cell and Neutrophil Counts and Response to Intravenous Immunoglobulin in Kawasaki Disease

Taichiro Muto, Yu Masuda, Shingo Numoto, Shunsuke Kodama et autres

We explored parameters to predicting the efficacy of intravenous immunoglobulin (IVIG) therapy for patients with Kawasaki disease (KD). We retrospectively analyzed the laboratory data of 77 children with KD treated with IVIG. Data obtained before and within 24 hours after IVIG therapy …

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Pseudoprogression successfully treated with bevacizumab in a child with spinal pilocytic astrocytoma

Kenji Miyata, Toshinori Hori, Yasuto Shimomura, Masahiro Joko et autres

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Medulloblastoma with epithelioid features in the cerebellar vermis

Kenji Miyata, Toshinori Hori, Kiyoshi Yamakawa, Michihiko Takasu et autres

A 6-year-old girl was admitted with a mass lesion in the cerebellar vermis. She underwent subtotal tumor resection, and on immunohistopathology the tumor consisted of two different parts: typical medulloblastoma (MB) characteristics and atypical teratoid/rhabdoid tumor (AT/RT) features, despite positive integrase interactor …

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Characterization of pediatric Philadelphia-negative B-cell precursor acute lymphoblastic leukemia with kinase fusions in Japan

Toshihiko Imamura, Nobutaka Kiyokawa, Motohiro Kato, Chihaya Imai et autres

Recent studies revealed that a substantial proportion of patients with high-risk B-cell precursor acute lymphoblastic leukemia (BCP-ALL) harbor fusions involving tyrosine kinase and cytokine receptors, such as ABL1, PDGFRB, JAK2 and CRLF2, which are targeted by tyrosine kinase inhibitors (TKIs). In the …

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Bacteremia Caused by Raoultella ornithinolytica in Two Children

Kiyoshi Yamakawa, Yuka Yamagishi, Kenji Miyata, Yasuto Shimomura et autres

We encountered 2 immunocompromised children complicated by Raoultella ornithinolytica bacteremia. One had received methylprednisolone pulse therapy for IgA nephropathy, and the other had leukopenia because of chemotherapy for leukemia. Both children had no specific symptoms, and R. ornithinolytica bacteremia was identified by …

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