Accès ouvert
2025
article
OpenAlex
Emmanuel Akoto, Ellen M. Doss, Kieran P. Claypool, Sophia L. Owutey et autres
Degradation of aberrant, excess, and regulatory proteins at the endoplasmic reticulum (ER) is a conserved feature of eukaryotic cells, disruption of which contributes to disease. While remarkable progress has been made in recent years, mechanisms and genetic requirements for ER-associated degradation (ERAD) …
us
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Accès ouvert
2024
article
OpenAlex
Sophia L. Owutey, Katrina A Procuniar, Emmanuel Akoto, Jacob C Davis et autres
deletion having a greater impact, consistent with characterized roles for Ubc6 and Ubc7 in ER and INM protein quality control.
us
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Accès ouvert
2022
article
OpenAlex
Sarah M. O’Keefe, Pratiti Bhadra, Kwabena B. Duah, Guanghui Zong et autres
The plant-derived macrocyclic resin glycoside ipomoeassin F (Ipom-F) binds to Sec61α and significantly disrupts multiple aspects of Sec61-mediated protein biogenesis at the endoplasmic reticulum, ultimately leading to cell death. However, extensive assessment of Ipom-F as a molecular tool and a therapeutic lead …
gb, de, us, tr
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Accès ouvert
2022
preprint
OpenAlex
Sarah M. O’Keefe, Pratiti Bhadra, Kwabena B. Duah, Guanghui Zong et autres
The macrocyclic small molecule inhibitor ipomoeassin F (Ipom-F) binds to the central Sec61α subunit of the Sec61 complex and induces cytotoxicity by disrupting multiple aspects of Sec61-mediated protein biogenesis at the endoplasmic reticulum (ER). Here, we show that the integrity of the …
gb, de, us, tr
(code pays fourni par la source)
Accès ouvert
2021
article
OpenAlex
Paweł Leźnicki, Hayden O. Schneider, Jada V. Harvey, Wei Shi et autres
Membrane proteins destined for lipid droplets (LDs), a major intracellular storage site for neutral lipids, are inserted into the endoplasmic reticulum (ER) and then trafficked to LDs where they reside in a hairpin loop conformation. Here, we show that LD membrane proteins …
gb, us
(code pays fourni par la source)
Accès ouvert
2021
preprint
OpenAlex
Paweł Leźnicki, Hayden O. Schneider, Jada V. Harvey, Wei Shi et autres
ABSTRACT Membrane proteins destined for lipid droplets (LDs), a major intracellular storage site for neutral lipids, are inserted into the endoplasmic reticulum (ER) and then trafficked to LDs where they reside in a hairpin loop conformation. Here, we show that LD membrane …
gb, us
(code pays fourni par la source)
Accès ouvert
2021
article
OpenAlex
Sarah M. O’Keefe, Peristera Roboti, Kwabena B. Duah, Guanghui Zong et autres
ABSTRACT In order to produce proteins essential for their propagation, many pathogenic human viruses, including SARS-CoV-2, the causative agent of COVID-19 respiratory disease, commandeer host biosynthetic machineries and mechanisms. Three major structural proteins, the spike, envelope and membrane proteins, are amongst several …
gb, us
(code pays fourni par la source)
Accès ouvert
2020
preprint
OpenAlex
Sarah M. O’Keefe, Peristera Roboti, Kwabena B. Duah, Guanghui Zong et autres
Abstract In order to produce proteins essential for their propagation, many pathogenic human viruses, including SARS-CoV-2 the causative agent of COVID-19 respiratory disease, commandeer host biosynthetic machineries and mechanisms. Three major structural proteins, the spike, envelope and membrane proteins, are amongst several …
gb, us
(code pays fourni par la source)