Accès ouvert
2022
article
OpenAlex
Peristera Roboti, Craig Lawless, Stephen High
The heterotrimeric BAG6 complex coordinates the direct handover of newly synthesised tail-anchored (TA) membrane proteins from an SGTA-bound preloading complex to the endoplasmic reticulum (ER) delivery component TRC40. In contrast, defective precursors, including aberrant TA proteins, form a stable complex with this …
gb
(code pays fourni par la source)
Accès ouvert
2021
preprint
OpenAlex
Peristera Roboti, Craig Lawless, Stephen High
ABSTRACT The heterotrimeric BAG6 complex coordinates the direct handover of newly synthesised tail-anchored (TA) membrane proteins from an SGTA-bound preloading complex to the endoplasmic reticulum (ER) delivery component TRC40. In contrast, defective precursors, including aberrant TA proteins, form a stable complex with …
gb
(code pays fourni par la source)
Accès ouvert
2021
article
OpenAlex
Gabrielle T. Parkinson, Peristera Roboti, Ling Zhang, Sandra D. Taylor et autres
His domain protein tyrosine phosphatase (HD-PTP; also known as PTPN23) collaborates with endosomal sorting complexes required for transport (ESCRTs) to sort endosomal cargo into intralumenal vesicles, forming the multivesicular body (MVB). Completion of MVB sorting is accompanied by maturation of the endosome …
gb
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Accès ouvert
2021
article
OpenAlex
Peristera Roboti, Sarah M. O’Keefe, Kwabena B. Duah, Wei Shi et autres
The Sec61 complex translocates nascent polypeptides into and across the membrane of the endoplasmic reticulum (ER), providing access to the secretory pathway. In this study, we show that Ipomoeassin-F (Ipom-F), a selective inhibitor of protein entry into the ER lumen, blocks the …
gb, us
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Accès ouvert
2021
article
OpenAlex
Sarah M. O’Keefe, Peristera Roboti, Kwabena B. Duah, Guanghui Zong et autres
ABSTRACT In order to produce proteins essential for their propagation, many pathogenic human viruses, including SARS-CoV-2, the causative agent of COVID-19 respiratory disease, commandeer host biosynthetic machineries and mechanisms. Three major structural proteins, the spike, envelope and membrane proteins, are amongst several …
gb, us
(code pays fourni par la source)
Accès ouvert
2020
preprint
OpenAlex
Sarah M. O’Keefe, Peristera Roboti, Kwabena B. Duah, Guanghui Zong et autres
Abstract In order to produce proteins essential for their propagation, many pathogenic human viruses, including SARS-CoV-2 the causative agent of COVID-19 respiratory disease, commandeer host biosynthetic machineries and mechanisms. Three major structural proteins, the spike, envelope and membrane proteins, are amongst several …
gb, us
(code pays fourni par la source)
Accès ouvert
2019
article
OpenAlex
Guanghui Zong, Zhijian Hu, Sarah M. O’Keefe, Dale Tranter et autres
Ipomoeassin F is a potent natural cytotoxin that inhibits growth of many tumor cell lines with single-digit nanomolar potency. However, its biological and pharmacological properties have remained largely unexplored. Building upon our earlier achievements in total synthesis and medicinal chemistry, we used …
us, gb, fi, cz, fr
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Accès ouvert
2019
preprint
OpenAlex
Wei Shi, Guanghui Zong, Zhijian Hu, Sarah M. O’Keefe et autres
The ipomoeassin family of natural resin glycosides is underexplored chemical space with potent antitumor activity revealed in the NCI-60 cell lines screen; however, its mode of action has so far remained unexplored. In this manuscript, we report our chemical proteomics and subsequent …
us
(code pays fourni par la source)
Accès ouvert
2019
preprint
OpenAlex
Wei Shi, Guanghui Zong, Zhijian Hu, Sarah M. O’Keefe et autres
The ipomoeassin family of natural resin glycosides is underexplored chemical space with potent antitumor activity revealed in the NCI-60 cell lines screen; however, its mode of action has so far remained unexplored. In this manuscript, we report our chemical proteomics and subsequent …
us
(code pays fourni par la source)
Accès ouvert
2018
article
OpenAlex
Santiago Martínez‐Lumbreras, E. Krysztofinska, Arjun Thapaliya, Alessandro Spilotros et autres
BACKGROUND: Protein quality control mechanisms are essential for cell health and involve delivery of proteins to specific cellular compartments for recycling or degradation. In particular, stray hydrophobic proteins are captured in the aqueous cytosol by a co-chaperone, the small glutamine-rich, tetratricopeptide repeat-containing …
gb, de
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Accès ouvert
2016
article
OpenAlex
Chunyi Liu, Mei Mei, Qiuling Li, Peristera Roboti et autres
The Golgi apparatus lies at the heart of the secretory pathway where it is required for secretory trafficking and cargo modification. Disruption of Golgi architecture and function has been widely observed in neurodegenerative disease, but whether Golgi dysfunction is causal with regard …
cn, gb
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Accès ouvert
2015
article
OpenAlex
Peristera Roboti, Keisuke Sato, Martin Lowe
Golgins are coiled-coil proteins that participate in membrane-tethering events at the Golgi complex. Golgin-mediated tethering is thought to be important for vesicular trafficking and Golgi organization. However, the degree to which individual golgins contribute to these processes is poorly defined, and it …
gb
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