N. Jannah M. Nasir

Abstract P54: Applying Machine Learning to Identify Enhancers of Immune Cell Functionality for Targeted Cancer Therapies

N. Jannah M. Nasir, John F. Ouyang, Valerie Chew, Owen J. L. Rackham

Abstract Drug discovery and testing are both time-consuming and costly. Leveraging single-cell transcriptomic data, we developed a machine learning framework to model patient cells using scRNA-seq data, aiming to infer gene regulatory networks (GRNs) that drive cell states and plasticity. Our computational …

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Targeting Treg–fibroblast interaction to enhance immunotherapy in steatotic liver disease-related hepatocellular carcinoma

Aldo Prawira, Hang Xu, Yu Mei, Wei Qiang Leow et autres

Background Steatotic liver disease-related hepatocellular carcinoma (SLD-HCC), a rising global challenge, is characterised by unique tumour microenvironment (TME) adaptations. Objective This study investigates the immune microenvironment and interactions driving immunosuppression and potential resistance to immunotherapy in SLD-HCC. Design We employed single-cell transcriptomics, …

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Immune and Histopathological Biomarkers for Prognosis and Neoadjuvant Immunotherapy Response in Intrahepatic Cholangiocarcinoma

N. Jannah M. Nasir, Edwin Jun Chen Chew, Kai Zhu, Gaohua Wu et autres

Introduction: The tumor microenvironment (TME) plays a critical role in determining the clinical outcomes in patients with intrahepatic cholangiocarcinoma (iCCA). This study investigates the prognostic significance of CD8+ T cells and regulatory T cells (Tregs) in tumor-infiltrating lymphocytes (TILs) and their relationship …

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Quantification of muscle fiber malformations using edge detection to investigate chronic muscle pressure ulcers

Charlene Z. L. Ong, N. Jannah M. Nasir, Roy E. Welsch, Lisa Tucker‐Kellogg et autres

Background: Microscopy of regenerated tissue shows different morphologies between the healing of acute wounds and chronic wounds. This difference can be seen manually by biologists, but computational methods are needed to automate the characterization of morphology and regenerative quality in regenerated muscle …

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GATA4 downregulation enhances CCL20-mediated immunosuppression in hepatocellular carcinoma

N. Jannah M. Nasir, Samuel Chuah, Timothy Wai Ho Shuen, Aldo Prawira et autres

BACKGROUND: Hepatocellular carcinoma (HCC) is a deadly cancer with a high global mortality rate, and the downregulation of GATA binding protein 4 (GATA4) has been implicated in HCC progression. In this study, we investigated the role of GATA4 in shaping the immune …

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Contributions of individual satellite cells to muscle regeneration assessed using a confetti mouse model

Hans Heemskerk, Narendra Suhas Jagannathan, N. Jannah M. Nasir, Binh Phu Nguyen et autres

Summary Insufficient regeneration is implicated in muscle pathologies, but much remains unknown about the regenerative output of individual muscle stem cells, called satellite cells (SCs). Prior work showed that individual SCs contribute to regeneration of more than one muscle fiber (“fiber-crossing”) after …

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Myoglobin-derived iron causes wound enlargement and impaired regeneration in pressure injuries of muscle

N. Jannah M. Nasir, Hans Heemskerk, Julia Jenkins, Nur Hidayah Hamadee et autres

The reasons for poor healing of pressure injuries are poorly understood. Vascular ulcers are worsened by extracellular release of hemoglobin, so we examined the impact of myoglobin (Mb) iron in murine muscle pressure injuries (mPI). Tests used Mb-knockout or treatment with deferoxamine …

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Author response: Myoglobin-derived iron causes wound enlargement and impaired regeneration in pressure injuries of muscle

N. Jannah M. Nasir, Hans Heemskerk, Julia Jenkins, Nur Hidayah Hamadee et autres

Myoglobin iron contributes to the formation and poor healing of muscle pressure injuries, that is, bedsores, and iron-chelation therapy can be administered after prolonged pressure to increase survival of the damaged tissue.

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Author Reply to Peer Reviews of Myoglobin-derived iron causes wound enlargement and impaired regeneration in pressure injuries of muscle

N. Jannah M. Nasir, Hans Heemskerk, Julia Jenkins, N. Hidayah Hamadee et autres

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Dataset for "Myoglobin-derived iron causes wound enlargement and impaired regeneration in pressure injuries of muscle"

N. Jannah M. Nasir, Hans Heemskerk, Julia Jenkins, Nur Hidayah Hamadee et autres

Primary images, data and quantification spreadsheets for "Myoglobin-derived iron causes wound enlargement and impaired regeneration in pressure injuries of muscle"

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Dataset for "Quantification of Muscle Fiber Malformations Using Edge Detection to Investigate Chronic Wound Healing"

Charlene Z. L. Ong, N. Jannah M. Nasir, Roy E. Welsch, Lisa Tucker‐Kellogg et autres

Primary images, spreadsheets and files for "Quantification of Muscle Fiber Malformations Using Edge Detection to Investigate Chronic Wound Healing" From the "Cardiotoxin" folder, "Stitch_A01_G001 incr bright" and "Stitch_A01_G001_0001 incr bright.jpg" were not used in the analysis. From the "PU + DFO" folder, …

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Dataset for "Quantification of Muscle Fiber Malformations Using Edge Detection to Investigate Chronic Wound Healing"

Charlene Z. L. Ong, N. Jannah M. Nasir, Roy E. Welsch, Lisa Tucker‐Kellogg et autres

Primary images, spreadsheets and files for "Quantification of Muscle Fiber Malformations Using Edge Detection to Investigate Chronic Wound Healing"

sg, us (code pays fourni par la source)