Denitsa Vlaykova

The Leucocyte Telomere Length, GSTM1 and GSTT1 Null Genotypes and the Risk of Chronic Obstructive Pulmonary Disease

Tanya Tacheva, Shanbeh Zienolddiny, Dimo Dimov, Denitsa Vlaykova et autres

Chronic obstructive pulmonary disease (COPD) is characterized by chronic inflammation and oxidative stress both in the airways and blood and other organs. Elevated oxidative stress and inflammation have been reported to affect leucocyte telomere length (LTL). Glutathione S-transferase (GST) enzymes are a …

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The leukocyte telomere length, single nucleotide polymorphisms near TERC gene and risk of COPD

Tanya Tacheva, Shanbeh Zienolddiny, Dimo Dimov, Denitsa Vlaykova et autres

Chronic obstructive pulmonary disease (COPD) is characterized by irreversible airflow obstruction and is associated with chronic local and systemic inflammation and oxidative stress. The enhanced oxidative stress and inflammation have been reported to affect telomere length (TL). Furthermore, a number of SNPs …

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The leucocyte telomere length, GSTM1 and GSTT1 null genotypes and the risk of COPD

Tanya Tacheva, Shanbeh Zienolddiny, Dimo Dimov, Heidi Notø et autres

Chronic obstructive pulmonary disease (COPD) is characterized by chronic inflammation and oxidative stress. The enhanced oxidative stress and inflammation have been reported to affect leucocyte telomere length (LTL). Glutathione S-transferase (GST) enzymes are a supergene family of phase II enzymes that utilize …

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Effects of the IL6 ‑174G>C promoter polymorphism and IL‑6 serum levels on the progression of cutaneous malignant melanoma

Tatyana Ivanova Vlaykova, Mateusz Kurzawski, Tanya Tacheva, Dimo Dimov et autres

Cutaneous malignant melanoma (CMM) is one of the most immunogenic types of cancer, with a 6‑fold higher rate of spontaneous regression than any other malignancy. In addition to responsiveness to different immunotherapies, the immunogenicity of CMM highlights the important role of the …

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Possible Role of Serum Leptin as Biomarker in COPD

Yanitsa Zhelyazkova, Tanya Tacheva, Dimo Dimov, Denitsa Vlaykova et autres

Leptin is one of the adipokines shown to exert a significant effect in respiratory diseases, including chronic obstructive pulmonary disease (COPD).The aim of the present study was to evaluate the possible role of serum leptin as biomarker in COPD.The serum leptin levels …

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Associations of an intron MMP9 polymorphism and the serum levels of gelatinase B with the development of COPD

Tanya Tacheva, Dimo Dimov, Yanitsa Zhelyazkova, Denitsa Vlaykova et autres

The main pathogenetic mechanisms involved in COPD are the abnormal inflammatory response of the lung to noxious particles and gases, local and systemic oxidative stress and extensive tissue remodeling of the airways. The latter process is mainly associated with protease/antiprotease imbalance and …

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Blood levels of matrix metalloproteinases (MMPs) and tissue inhibitors of matrix matalloproteinases (TIMPs) as biomarkers of COPD.

Dimo Dimov, Tanya Tacheva, Donika Ivanova, Yanitsa Zhelyazkova et autres

The imbalance between proteases and antiproteases has been considered as an important pathological mechanism in development of a number of conditions, including COPD. We aimed to explore the possible role of the blood levels of several MMPs (MMP-1, -2, -3 and -7), …

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Possible Influence ofGSTM1andGSTT1Null Genotype on the Risk for Development of Sporadic Colorectal Cancer

Tatyana Ivanova Vlaykova, Maya Vladova Gulubova, Denitsa Vlaykova, G. Cirovski et autres

The glutathione-S-transferases (GSTs) constitute a family of xenobiotic-metabolizing phase II enzymes, which mediate exposure to cytotoxic and genotoxic agents and may be involved in the susceptibility to cancer in general, and to colorectal cancers, particularly. For two of the genes, coding the …

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Original Contribution EXPRESSION OF THE XENOBIOTIC- AND REACTIVE OXYGEN SPECIES-DETOXIFYING ENZYMES, GST-Pi, Cu/Zn-SOD AND Mn-SOD IN PRIMARY HEPATOCELLULAR CARCINOMA

Tatyana Ivanova Vlaykova, Maya Vladova Gulubova, Denitsa Vlaykova, G. Cirovski et autres

Pathology of liver carcinogenesis in HCC includes generation of oxidative stress and up-regulation of inflammatory cytokines or vice versa. Our current study assessed the expression levels of detoxifying enzymes of xenobiotics and oxygen reactive species (ROS), particularly GST-pi, Cu/Zn-SOD and Mn-SOD, and …

Original Contribution EXPRESSION OF GST-PI AND ITS IMPACT ON THE SURVIVAL OF COLORECTAL CANCER PATIENTS UNDERGOING CHEMOTHERAPY

Tatyana Ivanova Vlaykova, Maya Vladova Gulubova, Denitsa Vlaykova, G. Cirovski et autres

Resistance to chemotherapeutic agents is a problem facing the oncologist. The glutathione-S-transferase (GST) enzyme system has been implicated in the development of resistance to several anticancer drugs. Our present study is aimed at evaluating the expression of GST-pi in colorectal carcinoma and …