Original Contribution EXPRESSION OF THE XENOBIOTIC- AND REACTIVE OXYGEN SPECIES-DETOXIFYING ENZYMES, GST-Pi, Cu/Zn-SOD AND Mn-SOD IN PRIMARY HEPATOCELLULAR CARCINOMA

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Pathology of liver carcinogenesis in HCC includes generation of oxidative stress and up-regulation of inflammatory cytokines or vice versa. Our current study assessed the expression levels of detoxifying enzymes of xenobiotics and oxygen reactive species (ROS), particularly GST-pi, Cu/Zn-SOD and Mn-SOD, and compared them with expression levels in the adjacent “normal” liver tissue. The expression of the enzymes was studied immunohistochemically in a small subset of 10 HCC biopsies obtained from 6 male and 4 female patients aged between 25 and 82 years. The expression level of GST-pi in tumour cells was significantly stronger than in the adjacent “normal” liver (p 0.999). Biopsies with stronger expression of Cu/Zn-SOD in “normal” liver was associated with lower serum levels of AlAT and AsAT (p=0.030, and p=0.190, respectively, ANOVA). We suggest that the changes in expression of xenobiotic- and ROS-detoxifying enzymes might be implicated in HCC via compromised response to injuring factors and their carcinogenic intermediators.

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