Xin Ye Qiu

SCD-Mediated Oleic Acid-PPARγ Self-Reinforcing Loop Drives Porcine Intramuscular Fat Deposition

Ruipeng Yang, Xixi Li, Wentong Tang, Xin Ye Qiu et autres

Intramuscular fat (IMF) deposition is a key determinant of pork quality and canonically regulated by peroxisome proliferator-activated receptor gamma (PPARγ). However, PPARγ expression levels do not always correlate directly with fat deposition, suggesting that transcript abundance alone is insufficient to account for …

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Impacts of ultrasonic osteotomy devices on bone regeneration and brain activity in a mouse model

Zonglin He, M. R. An, Dong Chen, Xin Ye Qiu et autres

Ultrasonic osteotomy devices (UODs) have emerged as precise bone-cutting instruments with soft tissue-sparing benefits; yet their impact on bone healing and adjacent neural tissue remains underexplored. This study aimed to investigate the effects of UODs versus conventional rotary high-speed burr (HSB) on …

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Polygenic Risk Score for the Efficacy of Clopidogrel in Patients With Minor Stroke or Transient Ischemic Attack: A Post Hoc Analysis of the CHANCE Trial

Xin Ye Qiu, Yingyu Jiang, Hongqiu Gu, Yong Jiang et autres

BACKGROUND: Dual antiplatelet therapy (DAPT) with clopidogrel and aspirin is recommended for secondary prevention in patients with a minor stroke or transient ischemic attack. However, the effectiveness of DAPT can be significantly influenced by genetic variations. This study aimed to estimate the …

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Impact of Clonal Hematopoiesis of Indeterminate Potential on the Long-Term Risk of Recurrent Stroke in Patients with a High Atherosclerotic Burden

Jiaxu Weng, Xin Ye Qiu, Yingyu Jiang, Hongqiu Gu et autres

AIMS: Clonal hematopoiesis of indeterminate potential (CHIP), which has recently been shown to be an age-related phenomenon, is associated with cardiovascular diseases, including atherosclerosis and stroke. This study focused on the association between CHIP and short- and long-term stroke recurrence in patients …

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Hepatitis B virus reactivation risk associated with immune checkpoint inhibitors in tumor treatment: a retrospective study

Yue Yin, Bao Jiang Liu, Y. Zhang, Xin Ye Qiu

BACKGROUND: Hepatitis B virus (HBV) reactivation is a recognized complication of cytotoxic chemotherapy in patients with chronic hepatitis B. However, the risk of HBV reactivation with immune checkpoint inhibitors (ICIs) remains uncertain due to their exclusion from clinical trials. This study aimed …

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Association between PPAR γ polymorphisms and neurological functional disability of ischemic stroke

Ran Yan, Xin Ye Qiu, Yalun Dai, Yingyu Jiang et autres

Peroxisome proliferator-activated receptor-γ ( PPARγ ) plays a protective role against brain injury after stroke in mice. However, the relationship between PPARγ gene polymorphisms and the functional outcome of acute ischemic stroke (AIS) remains unknown. 8822 patients from The Third China National …

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DNMT3A dysfunction promotes neuroinflammation and exacerbates acute ischemic stroke

Tian‐Jie Lyu, Xin Ye Qiu, Yübo Wang, Ling Zhang et autres

Abstract Somatic mutations related to clonal hematopoiesis of indeterminate potential (CHIP) are risk factors for stroke. The impact of DNMT3A, the most mutated gene in CHIP, on clinical functional outcomes of acute ischemic stroke (AIS) remains unclear. In a well‐characterized cohort of …

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A preliminary study of the mechanism of compound hearing loss caused by ototoxic drugs combined with impulse noise

Xin Ye Qiu, Qing‐qing Jiang, Weiwei Guo, Ning Yu et autres

Abstract Background Hearing loss (HL) is becoming increasingly common and is more commonly caused by noise, ototoxic substances, or a combination of ototoxic factors. However, so far, few studies have examined the mechanism by which compound factors cause HL. The only relevant …

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Genetics Of Intervertebral Disc Degeneration: Insights from Bibliometric and Single-Cell Transcriptomic Analysis

Feng Zhu, Zhenhui Zhao, Xin Ye Qiu, Chuiqin Fan et autres

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Association between clonal hematopoiesis-related gene mutations and unfavorable functional outcome in patients with large-artery atherosclerotic stroke

Xin Ye Qiu, Jiaxu Weng, Yingyu Jiang, Lingyun Cui et autres

Abstract Background Clonal hematopoiesis of indeterminate potential (CHIP) is a phenomenon that characterizes individuals with somatic mutations that are related to hematologic malignancy but without hematologic abnormalities. Presence of CHIP is associated with the atherosclerotic cardiovascular disease through the activation of the …

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Correction: Moderate elevation of serum uric acid levels improves short-term functional outcomes of ischemic stroke in patients with type 2 diabetes mellitus

Yalun Dai, Yingyu Jiang, Luping Zhang, Xin Ye Qiu et autres

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Moderate elevation of serum uric acid levels improves short-term functional outcomes of ischemic stroke in patients with type 2 diabetes mellitus

Yalun Dai, Yingyu Jiang, Luping Zhang, Xin Ye Qiu et autres

BACKGROUND: Serum uric acid (SUA), an end-product of purine catabolism diffused in the blood, is positively associated with the risk of type 2 diabetes mellitus (T2DM). However, in the T2DM population, the association of SUA fluctuation ([Formula: see text]SUA) with the functional …

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