Mohamad Azlan Nafiah

New Onoceranoid-Triterpenoids from the Stem Bark of Lansium domesticum Corr. cv. Piedjietan: Structural Characterization and Their Cytotoxic Activity Evaluated by In Vitro and In Silico Approaches

Rika Septiyanti, Selvi Aprliana Putri, Dilla Mardyana, Iman Permana Maksum et autres

This study presents the isolation, characterization and cytotoxic potential of four onoceranoid triterpenoids from the stem bark of Lansium domesticum Corr. cv. Piedjietan, including a newly identified compound, methyl lansic (1), and three known compounds: α,γ-onoceradienedione (2), methyl ester lansiolate (3), and …

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A new eudesmane type sesquiterpenoid from the stem bark of Aglaia pachyphylla with cytotoxic and anti-inflammatory activities

Wahyu Safriansyah, Josephine Elizabeth Siregar, Erina Hilmayanti, Siska Elisahbet Sinaga et autres

This study aims to isolate an undescribed eudesmane-type sesquiterpenoid, phyllunone A (1), along with 5 known sesquiterpenoids from n-hexane extract of Aglaia pachyphylla stem bark. The structural elucidation of compound 1 was achieved using NMR, HRMS, ECD, and was further supported by …

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Swiemagalins A-C: three new phragmalins from the stem barks of Indonesian Swietenia mahagoni and cytotoxic activities

Fajar Fauzi Abdullah, Al Arofatus Naini, Nurlelasari, Sofa Fajriah et autres

This study aimed to isolate three new phragmalin-type limonoids, swiemagalins A–C (1–3), as well as two known limonoids (4 and 5) from the stem barks of Indonesian Swietenia mahagoni. Compounds 1–3 were classified as highly oxygenated phragmalin-type limonoids, with 1 featuring an …

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Swiemagalins A-C: three new phragmalins from the stem barks of Indonesian Swietenia mahagoni and cytotoxic activities

Fajar Fauzi Abdullah, Al Arofatus Naini, Nurlelasari, Sofa Fajriah et autres

This study aimed to isolate three new phragmalin-type limonoids, swiemagalins A–C (1–3), as well as two known limonoids (4 and 5) from the stem barks of Indonesian Swietenia mahagoni. Compounds 1–3 were classified as highly oxygenated phragmalin-type limonoids, with 1 featuring an …

Swiemagalins A-C: three new phragmalins from the stem barks of Indonesian Swietenia mahagoni and cytotoxic activities

Fajar Fauzi Abdullah, Al Arofatus Naini, Nurlelasari, Sofa Fajriah et autres

This study aimed to isolate three new phragmalin-type limonoids, swiemagalins A–C (1–3), as well as two known limonoids (4 and 5) from the stem barks of Indonesian Swietenia mahagoni. Compounds 1–3 were classified as highly oxygenated phragmalin-type limonoids, with 1 featuring an …

A new eudesmane type sesquiterpenoid from the stem bark of Aglaia pachyphylla with cytotoxic and anti-inflammatory activities

Wahyu Safriansyah, Josephine Elizabeth Siregar, Erina Hilmayanti, Siska Elisahbet Sinaga et autres

This study aims to isolate an undescribed eudesmane-type sesquiterpenoid, phyllunone A (1), along with 5 known sesquiterpenoids from n-hexane extract of Aglaia pachyphylla stem bark. The structural elucidation of compound 1 was achieved using NMR, HRMS, ECD, and was further supported by …

A new eudesmane type sesquiterpenoid from the stem bark of Aglaia pachyphylla with cytotoxic and anti-inflammatory activities

Wahyu Safriansyah, Josephine Elizabeth Siregar, Erina Hilmayanti, Siska Elisahbet Sinaga et autres

This study aims to isolate an undescribed eudesmane-type sesquiterpenoid, phyllunone A (1), along with 5 known sesquiterpenoids from n-hexane extract of Aglaia pachyphylla stem bark. The structural elucidation of compound 1 was achieved using NMR, HRMS, ECD, and was further supported by …

Pachyphylinin A-B: two novel seco-apotirucallane triterpenoids with cytotoxic activities from the stem bark of Aglaia pachyphylla

Wahyu Safriansyah, Erina Hilmayanti, Rustaman, Kindi Farabi et autres

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A Review of Onoceranoids from the Lansium and Lycopodium Genera: Phytochemistry and Their Biological Activities

Rika Septiyanti, Rani Maharani, Mohamad Azlan Nafiah, Tri Mayanti

Onoceranoids, a subgroup of triterpenoids, have demonstrated considerable potential in medical applications due to their diverse biological activities. They exhibit antioxidant, cytotoxic, antimutagenic, antibacterial and antifeedant properties. This study aimed to review the phytochemical composition and biological activities of onoceranoids found in …

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Pachyphyllanone, a new cycloartane triterpenoid isolated from Aglaia pachyphylla and its cytotoxic activity

Wahyu Safriansyah, Endang Juliansyah, Rustaman, Al Arofatus Naini et autres

Aglaia pachyphylla is a species from the Aglaia genus (Meliaceae) and the chemical constituent has not been widely explored. A new cycloartane-type triterpenoid, pachyphyllanone (1), along with four known compounds (2-5) were isolated from Aglaia pachyphylla Miq. Furthermore, the structure of the …

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Triterpenoids From Swietenia mahagoni L Jacq. and Their Cytotoxic Activity against MCF-7 Breast Cancer and CV-1 Normal Kidney Cell Lines

Unang Supratman, Fajar Fauzi Abdullah, Kindi Farabi, Nurlelasari Nurlelasari et autres

ABSTRACT. Triterpenoid is a group of natural products with various remarkable activities, including cytotoxic. One of the sources for this type of compounds is Swietenia genus belong to Meliaceae family. This genus known to contains various secondary metabolites including limonoids, flavonoids, and …

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Four Azadirone-Type Limonoids from Chisocheton Pentandrus Stem Bark and Their Cytotoxic Acitivity Against Mcf-7 Breast Cancer Cell Lines

Unang Supratman, Dudi Runadi, Al Arofatus Naini, Purnama Purnama et autres

ABSTRACT. Limonoid group belongs to triterpenoid that has undergone further oxidation accompanied by the loss of four carbon atoms to form a furan ring in the chain. This limonoid compound is often found in the Chisocheton genus. Limonoid compounds have been known …

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