Thibaut Perchet

Bone marrow monocytes sustain NK cell-poiesis during non-alcoholic steatohepatitis

Elsa Bourayou, Thibaut Perchet, Sylvain Meunier, Hugo Bouvier et autres

Natural killer (NK) cells are the predominant lymphocyte population in the liver. At the onset of non-alcoholic steatohepatitis (NASH), an accumulation of activated NK cells is observed in the liver in parallel with inflammatory monocyte recruitment and an increased systemic inflammation. Using …

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A wave of bipotent T/ILC-restricted progenitors shapes the embryonic thymus microenvironment in a time-dependent manner

Ramy Elsaid, Sylvain Meunier, Odile Burlen‐Defranoux, Francisca Soares‐da‐Silva et autres

During embryonic development, multiple waves of hematopoietic progenitors with distinct lineage potential are differentially regulated in time and space. Two different waves of thymic progenitors colonize the fetal thymus where they contribute to thymic organogenesis and homeostasis. The origin, the lineage differentiation …

fr, pt (code pays fourni par la source)

Tbet promotes CXCR6 expression in immature natural killer cells and natural killer cell egress from the bone marrow

Antonia O. Cuff, Thibaut Perchet, Simone Dertschnig, Rachel Golub et autres

Summary Tbet‐deficient mice have reduced natural killer (NK) cells in blood and spleen, but increased NK cells in bone marrow and lymph nodes, a phenotype that is thought to be the result of defective migration. Here, we revisit the role of Tbet …

gb, fr (code pays fourni par la source)

Maintenance of Type 2 Response by CXCR6-Deficient ILC2 in Papain-Induced Lung Inflammation

Sylvain Meunier, Sylvestre Chea, Damien Garrido, Thibaut Perchet et autres

Innate lymphoid cells (ILC) are important players of early immune defenses in situations like lymphoid organogenesis or in case of immune response to inflammation, infection and cancer. Th1 and Th2 antagonism is crucial for the regulation of immune responses, however mechanisms are …

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A wave of embryonic bipotent T/lymphoid tissue inducer progenitors regulates the maturation of medullary thymic epithelial cells

Ramy Elsaid, Sylvain Meunier, Odile Burlen‐Defranoux, Francisca Soares‐da‐Silva et autres

SUMMARY Multiple waves of hematopoietic progenitors with distinct lineage potentials are differentially regulated in time and space. We show that the first thymic seeding progenitors comprise a unique population of bipotent cells that generate lymphoid tissue inducer and invariant V γ 5 …

fr, pt, gb (code pays fourni par la source)

Natural Killer Cells and Type 1 Innate Lymphoid Cells Are New Actors in Non-alcoholic Fatty Liver Disease

Carmelo Luci, E. G. J. Vieira, Thibaut Perchet, Philippe Gual et autres

Obesity and associated liver diseases (Non Alcoholic Fatty Liver Disease, NAFLD) are a major public health problem with increasing incidence in Western countries (25% of the affected population). These complications develop from a fatty liver (steatosis) to an inflammatory state (steatohepatitis) evolving …

fr (code pays fourni par la source)

Tbet promotes NK cell egress from the bone marrow and CXCR6 expression in immature NK cells

Antonia O. Cuff, Thibaut Perchet, Simone Dertschnig, Rachel Golub et autres

Tbet-deficient mice have reduced NK cells in blood and spleen, but increased NK cells in bone marrow and lymph nodes, a phenotype that is thought to be due to defective migration. Here, we revisit the role of Tbet in NK cell bone …

gb, fr (code pays fourni par la source)

Roles of hepatic group 1 ILC during the early stages of non-alcoholic fatty liver diseases

Thibaut Perchet

Les maladies du foies non-alcoholiques (NAFLD) representent un large spectre de pathologies qui comprennent la steatose ou la steatohepatite non alcoolique (NASH). Avec un nombre de patients diagnostique en constante augmentation, les NAFLD sont devenues un probleme majeur de sante publique dans …

Roles of hepatic group 1 ILC during the early stages of non-alcoholic fatty liver diseases

Thibaut Perchet

Rôles des cellules lymphoïdes innées du groupe 1 hépatiques au cours des étapes précoces des maladies du foie gras non-alcooliques Les maladies du foies non-alcoholiques (NAFLD) représentent un large spectre de pathologies qui comprennent la stéatose ou la stéatohepatite non alcoolique (NASH). …

fr (code pays fourni par la source)

Rôles des cellules lymphoïdes innées du groupe 1 hépatiques au cours des étapes précoces des maladies du foie gras non-alcooliques

Thibaut Perchet

Les maladies du foies non-alcoholiques (NAFLD) représentent un large spectre de pathologies qui comprennent la stéatose ou la stéatohepatite non alcoolique (NASH). Avec un nombre de patients diagnostiqué en constante augmentation, les NAFLD sont devenues un problème majeur de santé publique dans …

CCR 10+ ILC 2s with ILC 1‐like properties exhibit a protective function in severe allergic asthma

Chloé Beuraud, Vincent Lombardi, Sonia Luce, S. Horiot et autres

Abstract Background We previously showed that patients with severe allergic asthma have high numbers of circulating ILC2s expressing CCR10. Method Herein, CCR10+ ILC2s were further analyzed in the blood of healthy individuals or patients with allergic and non−allergic asthma. Characteristics of human …

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The Notch Signaling Pathway Is Balancing Type 1 Innate Lymphoid Cell Immune Functions

Thibaut Perchet, Maxime Petit, Elena-Gaia Banchi, Sylvain Meunier et autres

The Notch pathway is one of the canonical signaling pathways implicated in the development of various solid tumors. During carcinogenesis, the Notch pathway dysregulation induces tumor expression of Notch receptor ligands participating to escape the immune surveillance. The Notch pathway conditions both …

fr (code pays fourni par la source)