Peter C. K. Leung

Correction: Characterization of the roles of amphiregulin and transforming growth factor β1 in microvasculature-like formation in human granulosa-lutein cells

Hui Li, Hsun‐Ming Chang, 李赛姣, Christian Klausen et autres

ca, us, cn (code pays fourni par la source)

Role of the trophoblastic BMP7-TGM2 axis in the pathogenesis and prevention of preeclampsia

Qiaoqiao Ding, Mingxi Liu, Binbin Zhao, Yaxin Su et autres

Preeclampsia (PE) is a major hypertensive disorder of pregnancy and a leading cause of maternal and perinatal mortality and morbidity worldwide. Aberrant placental development, characterized by shallow trophoblast invasion and incomplete remodeling of maternal spiral arteries, remains central to PE pathogenesis. In …

cn, us, ca, fr (code pays fourni par la source)

Reevaluating statistical methods for proportion-based laboratory outcomes in assisted reproduction

Chaofeng Wei, Hsun‐Ming Chang, Chenggang Wang, Peter C. K. Leung et autres

BACKGROUND: Proportion-based laboratory outcomes in assisted reproductive technology (ART), including two-pronuclear fertilization rate, good-quality embryo rate, and blastocyst formation rate, are widely used to evaluate treatment effectiveness and laboratory performance. These outcomes are bounded between 0 and 1, frequently skewed, and arise …

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Resveratrol Alleviates Inflammation in Polycystic Ovary Syndrome by Inhibiting Absent in Melanoma 2 Expression

Qianjie Zhang, Hui Li, Yicen Meng, Weimin Zhao et autres

Since chronic inflammation is a typical feature of polycystic ovary syndrome (PCOS), both clinical and experimental studies have demonstrated that resveratrol (RES) can effectively alleviate it. However, the underlying mechanism remains unclear. To further investigate this, granulosa cells (GCs) derived from PCOS …

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Elucidating the roles of microRNA-103a-3p in trophoblast invasion and SOX4-mediated extravillous differentiation induced by activin A

Jiamin Xie, Matthew J. Shannon, Hua Zhu, Minyue Dong et autres

The dysregulation of growth factors is associated with defective trophoblast invasion, which leads to uteroplacental malperfusion due to the inadequate remodeling of spiral arteries. Pregnancy disorders, including preeclampsia, particularly early-onset preeclampsia, are closely related to compromised placental function caused by aberrant trophoblast …

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Effects Of A Preconception Lifestyle Intervention On Lifestyle Behaviors, Anthropometrics, And Fertility: The Schelti Cluster-Randomized Trial

Yulai Zhou, Rongdi Xu, Jean‐Patrice Baillargeon, Dongjian Yang et autres

Advances in human oocyte in vitro maturation: current status and future perspectives: a narrative review

Meiju Liu, Jie Cui, Hsun‐Ming Chang, Jing Liu et autres

Abstract: Oocyte in vitro maturation (IVM) is an evolving component of assisted reproductive technology (ART) that offers a less invasive and cost-effective alternative to conventional controlled ovarian stimulation. It is particularly beneficial for patients at risk of ovarian hyperstimulation syndrome (OHSS), those …

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Correction: Loss of CDYL results in suppression of CTNNB1 and decreased endometrial receptivity

Xiaowei Zhou, Bufang Xu, Dan Zhang, Xiaoping Jiang et autres

In the published article, there was an error in Figure 3C as published. The authors have identified that the CDYL-sh1 48h treatment was duplicated from CDYL-sh3 24h treatment due to an error during figure preparation. The corrected Figure 3C and its caption …

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Enhanced maturation of mouse immature oocytes using a novel three-dimensional culture system

Xinyang Zhao, Xudong Zhang, Shanshan Wu, Siwen Zhang et autres

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RNA modifications in female reproductive physiology and disease: emerging roles and clinical implications

Yu Xiang, Hsun‐Ming Chang, Peter C. K. Leung, Long Bai et autres

BACKGROUND: RNA modifications, collectively known as the epitranscriptome, represent the third layer of gene regulation, influencing gene expression at transcriptional, post-transcriptional, and translational levels. RNA-modifying proteins (RMPs), including writers, erasers, and readers, are responsible for depositing, removing, and recognizing chemical modifications on …

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EGF-like growth factors upregulate pentraxin 3 expression in human granulosa-lutein cells

Yuxi Li, Hsun‐Ming Chang, Hua Zhu, Yingpu Sun et autres

The epidermal growth factor (EGF)-like factors, comprising amphiregulin (AREG), betacellulin (BTC), and epiregulin (EREG), play a critical role in regulating the ovulatory process. Pentraxin 3 (PTX3), an essential ovulatory protein, is necessary for maintaining extracellular matrix (ECM) stability during cumulus expansion. The …

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Single-cell assessment of primary and stem cell-derived human trophoblast organoids as placenta-modeling platforms

Matthew J. Shannon, Gina L. McNeill, Burak Koksal, Jennet Baltayeva et autres

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