Xudong Zhang

Evidence of Early Selective Sertoli Cell Dysfunction in Varicocele: Inhibin B Reduction in Spermatic Vein

Chen Xiao, Jing Zhang, Shoubo Zhang, Tingfa Qiu et autres

cn, th (code pays fourni par la source)

Neutrophil membrane-mediated biomimetic nanoparticle for co-delivery of icariin and siORMDL3 attenuates asthma exacerbated by respiratory syncytial virus

Xudong Zhang, Ting Luan, Chenyu Zhao, Li Chen et autres

BACKGROUND: Asthma is a chronic inflammatory disorder, and respiratory syncytial virus (RSV) is a major trigger of asthma exacerbation. This study aimed to improve therapeutic efficacy against RSV-exacerbated asthma using neutrophil membrane (NM)-coated nanoparticles (NPs) for co-delivery of orosomucoid-like 3 (ORMDL3)-targeting small …

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Bridging bench to bedside: Exosome‑based strategies for endometriosis diagnosis and treatment (Review)

W Chen, Yanping Ma, Xudong Zhang, Siwen Zhang et autres

Endometriosis is a complex, chronic inflammatory gynecological disorder with estrogen‑dependent characteristics that severely impairs the quality of life of women and potentially leads to infertility. However, its pathogenesis remains poorly understood. Exosomes, small, discoid vesicles released by nearly all cell types, serve …

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Lymphoma-Associated Bone Marrow Hemophagocytosis (LA-BMHPC): A Retrospective, Single-Center Study of 67 Patients

Rong Hua, Meng Dong, Xudong Zhang, Honghan Qiao et autres

Objective: To investigate the clinical characteristics, management strategies, and prognostic outcomes of patients with lymphoma-associated bone marrow hemophagocytosis (LA-BMHPC).Methods: This retrospective, single-center cohort study enrolled patients diagnosed with LA-BMHPC between June 1, 2020, and June 30, 2023.We analyzed the clinical characteristics, treatment …

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FAK-dependent activation of src family kinase member BLK contributed to endometrial fibrosis via endoplasmic reticulum stress

Yimeng Lu, Xudong Zhang, Shanshan Wu, Siwen Zhang et autres

While Src family kinases (SFKs) are established mediators of some fibrotic diseases, their specific function in endometrial fibrosis is not well defined. Here, we investigated the function and underlying mechanism of B lymphoid tyrosine kinase (BLK), an SFK member, in driving endometrial …

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Enhanced maturation of mouse immature oocytes using a novel three-dimensional culture system

Xinyang Zhao, Xudong Zhang, Shanshan Wu, Siwen Zhang et autres

cn, tw, ca (code pays fourni par la source)

Genetic association between STAT1 and systemic lupus erythematosus: A two-sample Mendelian randomization observational study

Tingting Yang, Lu Wang, Liying Luo, Huimin Mei et autres

Systemic lupus erythematosus (SLE) is commonly observed in women of reproductive age and is often accompanied by other autoimmune conditions, such as Sjögren syndrome, rheumatoid arthritis, and thyroid diseases. The presence of comorbidities has the potential to negatively impact the overall health, …

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Risk prioritization and experimental validation of per- and polyfluoroalkyl substances (PFAS) in Chaohu Lake: Based on nontarget and target analyses

Wei Chang, Shendong Xu, Ting Liu, Lanlan Wu et autres

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Characteristics of Ordovician faults and their controlling effects on multilayer underground river reservoirs in Tahe oilfield, Tarim basin

Xudong Zhang, Qiang Jin, San Zhang

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Tong-Xie-Yao-Fang improves chronic intestinal fibrosis in mice with colitis through CRH-R2-mediated IL-6/STAT3 signaling pathway

Shiyi Wang, Xudong Zhang, Xiaojian Wang, Yihong Fan

Purpose: To investigate the potential mechanism of action of Tong-Xie-Yao-Fang (TXYF) on inflammation-related intestinal fibrosis in mice. In addition, to examine dextran sodium sulfate (DSS) induction and the stimulation of human intestinal fibroblasts (CCD-18Co) by transforming growth factorβ1 (TGF-β1). Methods: Chronic colitis …

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Plin4 exacerbates cadmium-decreased testosterone level via inducing ferroptosis in testicular Leydig cells

Xudong Zhang, Jian‐Jun Sun, Xinmei Zheng, Jin Zhang et autres

⁺ and testosterone in environmental stress-treated Leydig cells. Collectively, these results suggest that Plin4 exacerbates environmental stress-decreased testosterone level via inducing ferroptosis in testicular Leydig cells.

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Sirt1 m6A modification-evoked Leydig cell senescence promotes Cd-induced testosterone decline

Xinmei Zheng, Xudong Zhang, Lulu Tan, Jin Zhang et autres

Diminished testosterone levels have been documented as a key factor in numerous male health disorders. Both human and animal studies have consistently demonstrated that cadmium (Cd), a pervasive environmental heavy metal, results in decreased testosterone levels. However, the exact mechanism through which …

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