Munira Borhany

Global multicenter study establishes the reference range for ISTH Bleeding Assessment Tool scores in individuals under 18 years: communication from the SSC of the ISTH

Yousra Tera, Ryan Babensee, Ahmad Ekhtiar, Ahmad Darwish et autres

The International Society on Thrombosis and Haemostasis (ISTH) Bleeding Assessment Tool (BAT) is widely used to screen for inherited bleeding disorders. Adult reference ranges are age- and sex-specific. However, a single reference range (0-2) is currently applied to all individuals under 18 …

Égypte, ca, Nigéria, br, ae, pk, it, us, ie, au (code pays fourni par la source)

POSTER: CLL-465: Real-World Clinical Outcomes of Targeted Therapy in a Pakistani Cohort of Chronic Lymphocytic Leukemia

Munira Borhany, Warkha Thakur, Shagufta Hanif

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Genetic and Laboratory Predictors of Bleeding Severity in FVII Deficiency: Insights from PRO-RBDD and EN-RBD Databases

Samin Mohsenian, Andrea Cairo, Roberta Palla, Marzia Menegatti et autres

Factor VII deficiency (FVIID) is among the most common rare bleeding disorders. The ability of FVII coagulant activity (FVII:C) levels and genetic variants to predict clinical outcomes remains limited. We evaluated the discriminative performance of FVII:C, genotype-phenotype associations, and the accuracy of …

it, fr, ir, pk, gr (code pays fourni par la source)

Reducing mortality, improving outcomes, and establishing equity for women with classical haematological disease: a Lancet Haematology Commission

Luuk J J Scheres, Angela Weyand, Maureen K. Baldwin, Jecko Thachil et autres

nl, us, gb, ca, ie, Nigéria, ch, th, pk, ar, au, il, lb, co (code pays fourni par la source)

Impact of Pre‐Transplant Depth of Response on Outcomes in Patients With Multiple Myeloma: A Report on Behalf of Pakistan Blood and Marrow Transplant Group

Natasha Ali, Danyal Ahmed, Raheel Iftikhar, Ayesha Iftikhar et autres

BACKGROUND: Depth of response prior to autologous stem cell transplantation (ASCT) has been associated with improved progression-free survival (PFS) in multiple myeloma (MM). This study aimed to evaluate the impact of pre-transplant response depth on post-transplant outcomes in patients with multiple myeloma. …

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Hydroxyurea in Sickle Cell Disease: Coagulation and Activation in an Observational Study

Munira Borhany, Hafiza Tuba Iqbal, Madiha Abid, Sidra Zafar

Background: Sickle cell disease (SCD) is characterized by a chronic hypercoagulable state. Hydroxyurea (HU) is known to reduce the frequency of vaso-occlusive events and transfusion requirements in affected individuals. Objective: To assess the impact of hydroxyurea on biomarkers of coagulation (D-dimer) and …

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Clinical Spectrum, Subtype Distribution, and Treatment Outcomes in von Willebrand Disease: A Prospective Study from a Hemophilia Treatment Center in Pakistan

Munira Borhany, Heeba Qureshi, Nida Khurshid Ahmed, Maleeha Umair et autres

Introductionvon Willebrand Disease (VWD) is the most common inherited bleeding disorder, exhibiting diverse clinical manifestations depending on subtype and severity. This study aimed to assess the distribution of VWD subtypes, evaluate the correlation between Bleeding Assessment Tool (BAT) scores and clinical symptoms, …

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Patterns of Graft-Versus-Host Disease (GvHD) Prevention Practices in the Eastern Mediterranean (EM) Region: A Worldwide Network for Blood & Marrow Transplantation (WBMT) Global Study

Ibrahim N. Muhsen, Dietger Niederwieser, Laurent Garderet, Olaf Penack et autres

BACKGROUND: Preventing graft vs. host disease (GvHD) after allogeneic hematopoietic stem cell transplant (allo-HSCT) is essential to improving the outcomes and quality of life of allo-HSCT recipients. Little is known about the trends and patterns of global GvHD prevention practices. Thus, the …

us, de, fr, at, sa, kw, om, qa, lb, Algérie, pk, Maroc, jo, ir, Égypte, gb, hr, jp (code pays fourni par la source)

Acute and chronic graft-versus-host disease treatment and management in the Eastern Mediterranean region: A Worldwide Network for Blood and Marrow Transplantation survey

Ibrahim N. Muhsen, Dietger Niederwieser, Laurent Garderet, Olaf Penack et autres

BACKGROUND: The treatment of acute and chronic graft-versus-host disease (GvHD) remains a challenge, particularly in cases of steroid-refractory GvHD. The management of GvHD varies between institutions, and little is known regarding the practices in different regions of the world. Thus, the Worldwide …

us, de, fr, at, sa, kw, om, qa, lb, Algérie, pk, Maroc, jo, ir, Égypte, gb, hr, jp (code pays fourni par la source)

Acute and Chronic Graft Versus Host Disease (GVHD) Management in the Eastern Mediterranean Region: Result of the Worldwide Network for Blood & Marrow Transplantation (WBMT) Global GvHD Survey.

Ibrahim N. Muhsen, Dietger Niederwieser, Laurent Garderet, Olaf Penack et autres

Introduction Despite the approval of multiple therapies for acute and chronic GVHD over the past few years, it continues to be an area of need, particularly in cases of refractory GVHD where options remain limited. Objective To understand the current practices of …

us, de, fr, at, Tunisie, ca, sa, kw, om, qa, lb, pk (code pays fourni par la source)

Real World Outcomes of Autologous Stem Cell Transplant in Multiple Myeloma: A Study on Behalf of Plasma Cell Dyscrasia Working Party of Pakistan Blood and Marrow Transplant Group

Raheel Iftikhar, Danyal Ghani, Ammad Akram Chaudhary, Natasha Ali et autres

Introduction Early autologous stem cell transplant (ASCT) is recommended for transplant eligible multiple myeloma (MM) patients. However, there is a limited data on outcomes of ASCT in patients from low middle income countries (LMIC). Objective To report real world outcomes of ASCT …

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Impact of Pre-Transplant Depth of Response on Outcomes in Patients with Multiple Myeloma: A Report on Behalf of Pakistan Blood and Marrow Transplant Group

Raheel Iftikhar, Natasha Ali, Danyal Ghani, Maryam Khan et autres

Background: Newly diagnosed transplant eligible multiple myeloma (MM) patients, receive treatment prior to autologous stem cell transplant (ASCT) transplant for a finite period. Retrospective studies have shown improved progression free survival with deeper pre-ASCT responses. Our objective was to analyze the impact …

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