Martin Coenen

Delayed Plasma Amino Acid Response following Ingestion of Extruded Pea Protein Compared with Nonextruded Pea Proteins in Healthy Adults: A Randomized Crossover Trial

Lea Klug, Christina Diekmann, Christina Kopp, Ismail-Hakkı Acır et autres

Background Despite the growing availability of plant protein ingredients on the market, data on their digestibility and metabolic effects in humans are limited. Objective This study examined the effects of differently processed pea proteins on postprandial metabolism and compared them with those …

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Polygenic risk scores in pharmacogenomics: methodological challenges, current applications, and perspectives for clinical implementation

Carina M. Mathey, Martin Coenen, Ingolf Cascorbi, Per Hoffmann

Abstract Inter-individual variability in drug response remains a major challenge in clinical pharmacology. While clinical pharmacogenetics is largely based on actionable single-gene variants, increasing GWAS evidence indicates that many drug-response phenotypes are polygenic. Polygenic risk scores (PRS) offer a framework to capture …

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Calorie-restricted oat diet is associated with zonulin and short-chain fatty acid response in metabolic syndrome: a randomized controlled trial

Linda Klümpen, Aakash Mantri, Anna Donkers, Waldemar Seel et autres

Oats are associated with positive effects on gut health, but human studies are largely lacking. Therefore, we investigated the effects of two different oat diets on gut permeability makers in individuals with metabolic syndrome, each in a randomized, controlled parallel design. Participants …

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Cholesterol-lowering effects of oats induced by microbially produced phenolic metabolites in metabolic syndrome: a randomized controlled trial

Linda Klümpen, Aakash Mantri, Maren Philipps, Waldemar Seel et autres

Oats have various positive effects on human health, but the underlying mechanisms are not fully understood. To identify oat-microbiome-host interactions contributing to metabolic improvements, we conducted two randomized controlled dietary interventions in parallel-design in individuals with metabolic syndrome, comparing a short-term, high-dose …

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Dataset: Replication files for: Identifying Multi-omics Signatures that characterize Responders to Plant-based Dietary Interventions, v2

Alina Malin Schieren, Hanna Huber, Mohamed Yaghmour, Christoph Thiele et autres

This repository contains original unprocessed data and code for the replication of our paper Identifying Multi-omics Signatures that characterize Responders to Plant-based Dietary Interventions from a Randomized Trial.

Final Results of the ILLUMINATE-A Phase 3 Clinical Trial of Lumasiran for Primary Hyperoxaluria 1

Yaacov Frishberg, Jeffrey M. Saland, John Charles Lieske, W. J. Du et autres

KEY POINTS: Primary hyperoxaluria type 1 is a genetic disorder associated with hepatic oxalate overproduction, kidney failure, and systemic oxalosis. Lumasiran treatment for up to 60 months was associated with sustained reductions in urinary and plasma oxalate and encouraging clinical outcomes. Lumasiran's …

il, us, de, fr, nl, gb (code pays fourni par la source)

Fat Amount Rather Than Fatty Acid Composition Influences Postprandial Hunger, Satiety and Attention in Men and Women with a Risk Phenotype for Cardiometabolic Diseases: A Randomized Crossover Trial

Christina Diekmann, Tim Schiemann, Hannah F. Kienēs, Carolin Wiechmann et autres

BACKGROUND: Hunger and satiety are influenced by both the amount and composition of dietary fat. OBJECTIVES: This exploratory analysis examined the effects of meals enriched with different amounts of either canola oil (rich in unsaturated fatty acids) or coconut oil (rich in …

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Identifying Multi-omics Signatures that characterize Responders to Plant-based Dietary Interventions

Alina Schieren, Hanna Huber, Carolina Alvarez-Garavito, Aakash Mantri et autres

Metabolic responses to dietary interventions often show high inter-individual variations, but the factors explaining these variations as well as underlying mechanisms and their interrelation remain largely unknown. Knowing which factors are relevant for the individual response to a dietary intervention and to …

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Differential effects of Nordic and Vegetarian diets on lipid metabolism, gut microbiome and cardiometabolic risk factors: A multi-omic perspective from a randomized clinical intervention trial

Hanna Huber, Alina Schieren, A.C.D. Donkers, Aakash Mantri et autres

ABSTRACT Background Beneficial effects of diets with predominance of plant-based foods as fruits, vegetables, whole grain and plant-protein and less animal-based foods, or so-called “ plant-based ” diets, on cardiometabolic risk have been reported. We aimed to examine the effects of two …

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Modulating Placebo Effects in Clinical Trials: Study Team Briefing to Optimize Drug–Placebo Differences

Martin Coenen, Ulrike Bingel, Maria Soledad Berdaguer, Christine Fuhrmann et autres

Clinical trials often face challenges with placebo effects that can mask actual drug effects. We evaluated whether briefing the study team members on placebo mechanisms influenced analgesia. In this study, we compared the analgesic effects of oxycodone and placebo in three groups …

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Postprandial Responses to Meals Enriched With Canola or Coconut Oil in Men and Women With a Risk Phenotype for Cardiometabolic Diseases: A Randomized Crossover Trial

Hannah F. Kienēs, Christina Diekmann, Tim Schiemann, Carolin Wiechmann et autres

We investigated the metabolic response to meals with canola or coconut oil (rich in unsaturated vs. rich in saturated fatty acids [FAs]). Although the longer-term metabolic effects of these fats are well evidenced, their postprandial effects remain inconclusive. In this randomized crossover …

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PD33-02 LONG-TERM EFFECTS OF LUMASIRAN ON KIDNEY STONES AND NEPHROCALCINOSIS IN PATIENTS WITH PRIMARY HYPEROXALURIA TYPE 1

Gregory E. Tasian, Jeffrey M. Saland, John Charles Lieske, Yaacov Frishberg et autres