Jan Paul Buschdorf

SRSF9 selectively represses ADAR2-mediated editing of brain-specific sites in primates

Raghuvaran Shanmugam, Fan Zhang, Harini Srinivasan, John Lalith Charles Richard et autres

Adenosine-to-inosine (A-to-I) RNA editing displays diverse spatial patterns across different tissues. However, the human genome encodes only two catalytically active editing enzymes (ADAR1 and ADAR2), suggesting that other regulatory factors help shape the editing landscape. Here, we show that the splicing factor …

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Effect of human milk formula with bovine colostrum supplementation on bone mineral density in infant cynomolgus macaques

Nicole Tay, Youran Tan, Keefe Chng, Camilo Libedinsky et autres

Insulin-like growth factor 1 (IGF1) is a regulator of human growth during infancy and childhood, known to promote bone and muscle growth as well as lipid accumulation. This study aimed to investigate the effects of formula milk with or without IGF1 supplementation …

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Low birth weight associates with hippocampal gene expression

Jan Paul Buschdorf, Mei‐Lyn Ong, S.X. Ong, Julia L. MacIsaac et autres

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Epigenetics/Programming in the HPA Axis

Jan Paul Buschdorf, Michael Joseph Meaney

ABSTRACT The hypothalamic‐pituitary‐adrenal axis provides physiological adaptations to various environmental stimuli in mammals. These stimuli including maternal care, diet, immune challenge, stress, and others have the potential to stably modify or program the functioning of the HPA axis when experienced early in …

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Epigenetics/Programming in the HPA Axis

Jan Paul Buschdorf, Michael Joseph Meaney

The hypothalamic-pituitary-adrenal axis provides physiological adaptations to various environmental stimuli in mammals. These stimuli including maternal care, diet, immune challenge, stress, and others have the potential to stably modify or program the functioning of the HPA axis when experienced early in life …

sg, ca (code pays fourni par la source)

Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism influences the association of the methylome with maternal anxiety and neonatal brain volumes

Li Chen, Hong Pan, Ta Anh Tuan, Ai Ling Teh et autres

Early life environments interact with genotype to determine stable phenotypic outcomes. Here we examined the influence of a variant in the brain-derived neurotropic factor (BDNF) gene (Val66Met), which underlies synaptic plasticity throughout the central nervous system, on the degree to which antenatal …

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Infinium Monkeys: Infinium 450K Array for the Cynomolgus macaque (Macaca fascicularis)

Mei‐Lyn Ong, Peck Yean Tan, Julia L. MacIsaac, Sarah M Mah et autres

The Infinium Human Methylation450 BeadChip Array (Infinium 450K) is a robust and cost-efficient survey of genome-wide DNA methylation patterns. Macaca fascicularis (Cynomolgus macaque) is an important disease model; however, its genome sequence is only recently published, and few tools exist to interrogate …

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The effect of genotype and in utero environment on interindividual variation in neonate DNA methylomes

Ai Ling Teh, Hong Pan, Li Chen, Mei‐Lyn Ong et autres

Integrating the genotype with epigenetic marks holds the promise of better understanding the biology that underlies the complex interactions of inherited and environmental components that define the developmental origins of a range of disorders. The quality of the in utero environment significantly …

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Decreased hippocampal mineralocorticoid:glucocorticoid receptor ratio is associated with low birth weight in female cynomolgus macaque neonates

Shirlene X Ong, Keefe Chng, Michael Joseph Meaney, Jan Paul Buschdorf

During pregnancy, glucocorticoids transfer environmental signals to the growing brain and its associated neuroendocrine system to modulate their maturation and function during adolescence and adulthood. Increased in utero exposure to glucocorticoids is associated with impaired fetal growth resulting in low birth weight …

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Conference Scene: Epigenetics Goes Translational

Jan Paul Buschdorf, Patrick K.M. Lee, Vania K.J. Lim, Laurent Kappeler et autres

Keystone Symposia held one of its five global conferences outside of North America in Singapore on 26–30 April 2010, entitled ‘Developmental Origins and Epigenesis in Human Health and Disease’. This was organized by Judith Swain, Peter Gluckman, Michael Meaney and Anne Ferguson-Smith …

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The SAM domain of the RhoGAP DLC1 binds EF1A1 to regulate cell migration

Dandan Zhong, Jingfeng Zhang, Shuai Yang, Unice J. K. Soh et autres

Deleted in liver cancer 1 (DLC1) is a multi-modular Rho-GTPase-activating protein (RhoGAP) and a tumor suppressor. Besides its RhoGAP domain, functions of other domains in DLC1 remain largely unknown. By protein precipitation and mass spectrometry, we identified eukaryotic elongation factor 1A1 (EF1A1) …

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Nerve Growth Factor Stimulates Interaction of Cayman Ataxia Protein BNIP-H/Caytaxin with Peptidyl-Prolyl Isomerase Pin1 in Differentiating Neurons

Jan Paul Buschdorf, Li Li Chew, Unice J. K. Soh, Yih‐Cherng Liou et autres

Mutations in ATCAY that encodes the brain-specific protein BNIP-H (or Caytaxin) lead to Cayman cerebellar ataxia. BNIP-H binds to glutaminase, a neurotransmitter-producing enzyme, and affects its activity and intracellular localization. Here we describe the identification and characterization of the binding between BNIP-H …

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