A. Colantuoni

Selective Production of Syringaldehyde and Vanillin from Acetal-Stabilized Lignin

Jean Behaghel de Bueren, Wu Lan, A. Colantuoni, Tom Nelis et autres

Industrial lignin oxidation has been used for vanillin production but is largely uncontrolled, not fully understood mechanistically, and leads to low yield. Here, we have demonstrated high-efficiency vanillin and syringaldehyde production from lignin via guaiacyl and syringyl α-diketones. These molecules can be …

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Microvascular Dysfunction Related to COVID-19 and Systemic Inflammation

Dominga Lapi, Martina Chiurazzi, Espedita Muscariello, A. Colantuoni

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L-Arginine and Taurisolo® Effects on Brain Hypoperfusion–Reperfusion Damage in Hypertensive Rats

Dominga Lapi, Gian Carlo Tenore, Giuseppe Federighi, Martina Chiurazzi et autres

Acute and chronic hypertension causes cerebral vasculopathy, increasing the risk of ischemia and stroke. Our study aimed to compare the effects of arterial pressure reduction on the pial microvascular responses induced by hypoperfusion and reperfusion in spontaneously hypertensive Wistar rats, desamethasone-induced hypertensive …

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Editorial: Vascular function and mechanisms of aging: hypertension, obesity and metabolic disorders

Eduardo Nava, Andreea Trache, Alejandro Díaz, A. Colantuoni

Editorial on the Research Topic Vascular function and mechanisms of aging: hypertension, obesity and metabolic disordersWithin the context of age-related decline, quality of life is intensely affected by the functional deterioration of the cardiovascular system.Understanding the role of obesity, hypertension, and metabolic …

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The Effects of a Cinchona Supplementation on Satiety, Weight Loss and Body Composition in a Population of Overweight/Obese Adults: A Controlled Randomized Study

Martina Chiurazzi, Barbara De Conno, Mariastella Di Lauro, Bruna Guida et autres

Obesity is a risk factor for several diseases present worldwide. Currently, dietary changes and physical activity are considered the most effective treatment to reduce obesity and its associated comorbidities. To promote weight loss, hypocaloric diets can be supported by nutraceuticals. The aim …

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Editorial: Methods and applications in vascular physiology: 2022

A. Colantuoni, Julien V. Brugniaux, Alexey Goltsov, Rosalía Rodríguez‐Rodríguez

This Research Topic is a part of the Methods and Applications in Physiology series and builds on the successful publication of the "Methods and Applications in Vascular Physiology: 2022".In current issue, we included manuscripts devoted to novel methods and protocols and extension …

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Caloric Restriction (CR) Plus High-Nitrate Beetroot Juice Does Not Amplify CR-Induced Metabolic Adaptation and Improves Vascular and Cognitive Functions in Overweight Adults: A 14-Day Pilot Randomised Trial

Mushari Alharbi, Martina Chiurazzi, G. Nasti, Espedita Muscariello et autres

Caloric restriction (CR) and dietary nitrate supplementation are nutritional interventions with pleiotropic physiological functions. This pilot study investigates the combined effects of CR and nitrate-rich beetroot juice (BRJ) on metabolic, vascular, and cognitive functions in overweight and obese middle-aged and older adults. …

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Effects of physical exercise associated with a diet enriched with natural antioxidants on cerebral hypoperfusion and reperfusion injury in spontaneously hypertensive rats

Dominga Lapi, Giuseppe Federighi, Maria Serena Lonardo, Martina Chiurazzi et autres

Oxidative stress is implicated in the pathogenesis of arterial hypertension. The reduction in the bioavailability of nitric oxide (NO) causes endothelial dysfunction, altering the functions of cerebral blood vessels. Physical exercise and intake of antioxidants improve the redox state, increasing the vascular …

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Editorial: Methods and applications in vascular physiology: 2021

Julien V. Brugniaux, Rosalía Rodríguez‐Rodríguez, Ali Dabiri, Kıvılcım Kılıç et autres

Methods and applications

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The Effects of Angiotensin II or Angiotensin 1-7 on Rat Pial Microcirculation during Hypoperfusion and Reperfusion Injury: Role of Redox Stress

Dominga Lapi, Maurizio Cammalleri, Massimo Dal Monte, Martina Di Maro et autres

Renin–angiotensin systems produce angiotensin II (Ang II) and angiotensin 1-7 (Ang 1-7), which are able to induce opposite effects on circulation. This study in vivo assessed the effects induced by Ang II or Ang 1-7 on rat pial microcirculation during hypoperfusion–reperfusion, clarifying …

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Geometric Features of the Pial Arteriolar Networks in Spontaneous Hypertensive Rats: A Crucial Aspect Underlying the Blood Flow Regulation

Dominga Lapi, Martina Di Maro, Martina Chiurazzi, M. Varanini et autres

BACKGROUND: Several studies indicate that hypertension causes major changes in the structure of the vessel wall by affecting the regulation of blood supply to the tissues. Recently, it has been observed that capillary blood flow is also considerably influenced by the structural …

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The Cholinergic and ACE-2-Dependent Anti-Inflammatory Systems in the Lung: New Scenarios Emerging From COVID-19

Martina Di Maro, Mauro Cataldi, Mariarosaria Santillo, Martina Chiurazzi et autres

The renin angiotensin system and the cholinergic anti-inflammatory pathway have been recently shown to modulate lung inflammation in patients with COVID-19. We will show how studies performed on this disease are starting to provide evidence that these two anti-inflammatory systems may functionally …

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