Sarah A.E. Aboushawareb

Dermoscopy Education in Undergraduate Medical Education: Scoping Review of Pedagogical Approaches and Gaps

Sarah Moussa, Ammar Saed Aldien, Sarah A.E. Aboushawareb, Renata Sava et autres

Purpose A dermatoscope, a hand-held magnifying polarized illuminating device, is a powerful tool in the clinician's tool kit for skin cancer examination (SCE), allowing for better screening and diagnostic accuracy. Yet, few physicians are trained to leverage its potential. This scoping review …

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Understanding the Processes of Role Adoption in Pedagogical Role-Play Games (RPGs): A Narrative Dramaturgical Perspective on “Social RPGs” in Health Professions Education

Sarah A.E. Aboushawareb, Gillian Bartlett, Amalia M. Issa, Tracie A. Barnett et autres

Background Health professional training interventions based on role-playing games (RPGs) have been shown to be an increasingly popular way to advance health professional students’ skills in communication and empathetic engagement with patients and colleagues. However, role adoption itself is largely assumed, with …

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An Active-Site Bronsted Acid–Base Catalyst Destabilizes Mandelate Racemase and Related Subgroup Enzymes: Implications for Catalysis

H R Hemantha Kumar, Oliver P. Kuehm, Sarah A.E. Aboushawareb, Atieh Rafiei et autres

Enzymes of the enolase superfamily (ENS) are mechanistically diverse, yet share a common partial reaction, i.e., the metal-assisted, Bro̷nsted base-catalyzed abstraction of the α-proton from a carboxylate substrate to form an enol(ate) intermediate. Although the catalytic machinery responsible for the initial deprotonation …

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Exploring approaches to teaching communication practices for shared decision-making in medical education: A scoping review

Sarah A.E. Aboushawareb, Saki Sultana, Peter Nugus, Tracie A. Barnett et autres

Objective Health professional education researchers have documented increased training on shared decision-making (SDM) skills in undergraduate as well as continuing professional development (CPD). In this review, we seek to understand the current methods and approaches to teaching SDM for healthcare providers and …

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Deliberations About Clinical Pharmacogenetic Testing in Pediatric Oncology

Amalia M. Issa, Sarah A.E. Aboushawareb, David D. Eisenstat, Greg Guilcher et autres

This article summarizes the background, content and outcomes of a special meeting that was convened among oncologists and scientists to discuss the role of pharmacogenetic (PGx) testing in pediatric clinical oncology practice. This meeting provided an opportunity for what the lead author …

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Identification and characterization of hippuristanol-resistant mutants reveals eIF4A1 dependencies within mRNA 5′ leader regions

Jutta Steinberger, Leo Shen, Stephen J. Kiniry, Sai Kiran Naineni et autres

Hippuristanol (Hipp) is a natural product that selectively inhibits protein synthesis by targeting eukaryotic initiation factor (eIF) 4A, a DEAD-box RNA helicase required for ribosome recruitment to mRNA templates. Hipp binds to the carboxyl-terminal domain of eIF4A, locks it in a closed …

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Excess body weight as a predictor of response to treatment with antidepressants in patients with depressive disorder

Svetlana Puzhko, Sarah A.E. Aboushawareb, Irina Kudrina, Tibor Schuster et autres

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RECOGNITION OF “MINIMAL” LIGANDS BY ENOLASE SUPERFAMILY ENZYMES

Sarah A.E. Aboushawareb

Enolase superfamily (ENS) enzymes share a common half-reaction, the Mg2+-dependent, Brønsted base-catalyzed abstraction of an α-proton from a carboxylic acid substrate to form an enolate. The active site architecture of the ENS enzymes L-talarate/galactarate dehydratase (TGD), D-(-)-tartrate dehydratase (TarD), and β-methylaspartate ammonia-lyase …

A continuous assay for l-talarate/galactarate dehydratase using circular dichroism

Nicole M. Easton, Sarah A.E. Aboushawareb, Stephen L. Bearne

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